Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              17    3301
NP_671714                                                              17    3301
XP_006715890                                                           17    3301
XP_005250160                                                           17    3301
XP_005250159                                                           17    3301
NP_006653                                                              16    5631
NP_001256                                                              16    7355
NP_003310                                                              15    9605
NP_597676                                                              15    9605
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_001273897                                                           15    9605
NP_005345                                                              15    9605
NP_001092809                                                           15    9605
NP_444269                                                              15    9605
NP_872327                                                              15    9605
XP_005260357                                                           15    9605
XP_005260356                                                           15    9605
XP_005246888                                                           15    9605
XP_006712788                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_073754                                                              15    9605
NP_001254479                                                           15    9605
NP_597681                                                              15    9605
>NP_005742
          Length = 3907

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTLGISE 9
            SALTL ISE
Sbjct: 2602 SALTLRISE 2610
>NP_671714
          Length = 3899

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTLGISE 9
            SALTL ISE
Sbjct: 2594 SALTLRISE 2602
>XP_006715890
          Length = 3860

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTLGISE 9
            SALTL ISE
Sbjct: 2555 SALTLRISE 2563
>XP_005250160
          Length = 3939

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTLGISE 9
            SALTL ISE
Sbjct: 2634 SALTLRISE 2642
>XP_005250159
          Length = 3952

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    SALTLGISE 9
            SALTL ISE
Sbjct: 2647 SALTLRISE 2655
>NP_006653
          Length = 3230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    SALTLGIS 8
            SALTLG++
Sbjct: 1503 SALTLGLA 1510
>NP_001256
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ALTLGISE 9
           A TLG+SE
Sbjct: 220 AATLGLSE 227
>NP_003310
          Length = 26926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ALTLGIS 8
            A+TLG+S
Sbjct: 9876 AMTLGVS 9882
>NP_597676
          Length = 27051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     ALTLGIS 8
             A+TLG+S
Sbjct: 10001 AMTLGVS 10007
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     ALTLGIS 8
             A+TLG+S
Sbjct: 17300 AMTLGVS 17306
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     ALTLGIS 8
             A+TLG+S
Sbjct: 16373 AMTLGVS 16379
>NP_001273897
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ALTLGISE 9
          ALTL +SE
Sbjct: 6  ALTLSLSE 13
>NP_005345
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ALTLGISE 9
          ALTL +SE
Sbjct: 49 ALTLSLSE 56
>NP_001092809
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTLGISE 9
           +TLG+SE
Sbjct: 96  ITLGLSE 102
>NP_444269
          Length = 200

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTLGISE 9
           +TLG+SE
Sbjct: 97  ITLGLSE 103
>NP_872327
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   SALTLGISE 9
           SAL LG+ E
Sbjct: 95  SALQLGLGE 103
>XP_005260357
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTLGISE 9
           +TLG+SE
Sbjct: 96  ITLGLSE 102
>XP_005260356
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LTLGISE 9
           +TLG+SE
Sbjct: 97  ITLGLSE 103
>XP_005246888
          Length = 22663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ALTLGIS 8
            A+TLG+S
Sbjct: 5613 AMTLGVS 5619
>XP_006712788
          Length = 24022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ALTLGIS 8
            A+TLG+S
Sbjct: 6972 AMTLGVS 6978
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     ALTLGIS 8
             A+TLG+S
Sbjct: 16928 AMTLGVS 16934
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     ALTLGIS 8
             A+TLG+S
Sbjct: 18434 AMTLGVS 18440
>NP_073754
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SALTLGISE 9
           + LT+GIS+
Sbjct: 304 ATLTIGISD 312
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     ALTLGIS 8
             A+TLG+S
Sbjct: 18941 AMTLGVS 18947
>NP_597681
          Length = 27118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2     ALTLGIS 8
             A+TLG+S
Sbjct: 10068 AMTLGVS 10074
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.122    0.286 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 360,995
Number of extensions: 338
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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