Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           17    3301
NP_004561                                                              17    3301
NP_001275703                                                           17    3301
XP_005253450                                                           17    3301
XP_006719151                                                           17    3301
NP_857597                                                              16    5631
NP_849189                                                              15    9605
NP_006552                                                              15    9605
NP_001077060                                                           15    9605
NP_001020248                                                           15    9605
NP_001020247                                                           15    9605
NP_006551                                                              15    9605
NP_001166110                                                           15    9605
NP_941989                                                              15    9605
NP_004437                                                              15    9605
NP_001166111                                                           15    9605
NP_001020767                                                           15    9605
XP_006718194                                                           15    9605
XP_006718193                                                           15    9605
XP_006718192                                                           15    9605
XP_006718191                                                           15    9605
XP_006718190                                                           15    9605
XP_005252813                                                           15    9605
XP_005252812                                                           15    9605
XP_006718189                                                           15    9605
XP_006718188                                                           15    9605
XP_006718187                                                           15    9605
XP_005252811                                                           15    9605
XP_006718186                                                           15    9605
XP_006718185                                                           15    9605
XP_005269574                                                           15    9605
XP_006717681                                                           15    9605
XP_005252414                                                           15    9605
XP_005252415                                                           15    9605
XP_006717438                                                           15    9605
XP_006717437                                                           15    9605
XP_006717436                                                           15    9605
XP_006717435                                                           15    9605
XP_006717434                                                           15    9605
XP_005252411                                                           15    9605
XP_006717433                                                           15    9605
XP_006717432                                                           15    9605
XP_006717431                                                           15    9605
XP_006717430                                                           15    9605
XP_005252408                                                           15    9605
XP_005252406                                                           15    9605
XP_005252405                                                           15    9605
XP_006717429                                                           15    9605
XP_006717428                                                           15    9605
>NP_001275701
          Length = 1486

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SAKVLIEKV 9
           SAK LIEKV
Sbjct: 474 SAKGLIEKV 482
>NP_004561
          Length = 1445

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SAKVLIEKV 9
           SAK LIEKV
Sbjct: 474 SAKGLIEKV 482
>NP_001275703
          Length = 1264

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SAKVLIEKV 9
           SAK LIEKV
Sbjct: 252 SAKGLIEKV 260
>XP_005253450
          Length = 1486

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SAKVLIEKV 9
           SAK LIEKV
Sbjct: 474 SAKGLIEKV 482
>XP_006719151
          Length = 1486

 Score = 16.9 bits (32), Expect =  3301
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SAKVLIEKV 9
           SAK LIEKV
Sbjct: 474 SAKGLIEKV 482
>NP_857597
          Length = 1349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   SAKVLIEKV 9
           +AK+L+E+V
Sbjct: 924 TAKILLERV 932
>NP_849189
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AKVLIEK 8
          AKV++EK
Sbjct: 46 AKVMVEK 52
>NP_006552
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 464 SAKVFIDK 471
>NP_001077060
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 431 SAKVFIDK 438
>NP_001020248
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 451 SAKVFIDK 458
>NP_001020247
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 433 SAKVFIDK 440
>NP_006551
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 425 SAKVFIDK 432
>NP_001166110
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 455 SAKVFIDK 462
>NP_941989
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 426 SAKVFIDK 433
>NP_004437
          Length = 1512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AKVLIEKV 9
           AKVL +KV
Sbjct: 901 AKVLFDKV 908
>NP_001166111
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 428 SAKVFIDK 435
>NP_001020767
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 429 SAKVFIDK 436
>XP_006718194
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 430 SAKVFIDK 437
>XP_006718193
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 430 SAKVFIDK 437
>XP_006718192
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 430 SAKVFIDK 437
>XP_006718191
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 430 SAKVFIDK 437
>XP_006718190
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 456 SAKVFIDK 463
>XP_005252813
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 457 SAKVFIDK 464
>XP_005252812
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 462 SAKVFIDK 469
>XP_006718189
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 462 SAKVFIDK 469
>XP_006718188
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 465 SAKVFIDK 472
>XP_006718187
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 465 SAKVFIDK 472
>XP_005252811
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 466 SAKVFIDK 473
>XP_006718186
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 466 SAKVFIDK 473
>XP_006718185
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 466 SAKVFIDK 473
>XP_005269574
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AKVLIEK 8
          AKV++EK
Sbjct: 58 AKVMVEK 64
>XP_006717681
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AKVLIEK 8
          AKV++EK
Sbjct: 64 AKVMVEK 70
>XP_005252414
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 223 SAKVFIDK 230
>XP_005252415
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 223 SAKVFIDK 230
>XP_006717438
          Length = 290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 233 SAKVFIDK 240
>XP_006717437
          Length = 290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 233 SAKVFIDK 240
>XP_006717436
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 346 SAKVFIDK 353
>XP_006717435
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 350 SAKVFIDK 357
>XP_006717434
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 350 SAKVFIDK 357
>XP_005252411
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 457 SAKVFIDK 464
>XP_006717433
          Length = 518

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 461 SAKVFIDK 468
>XP_006717432
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 468 SAKVFIDK 475
>XP_006717431
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 473 SAKVFIDK 480
>XP_006717430
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 480 SAKVFIDK 487
>XP_005252408
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 482 SAKVFIDK 489
>XP_005252406
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 486 SAKVFIDK 493
>XP_005252405
          Length = 545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 488 SAKVFIDK 495
>XP_006717429
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 492 SAKVFIDK 499
>XP_006717428
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAKVLIEK 8
           SAKV I+K
Sbjct: 492 SAKVFIDK 499
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.127    0.278 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 346,104
Number of extensions: 439
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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