Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              19     869
NP_444254                                                              19     869
NP_444253                                                              19     869
NP_444255                                                              19     869
XP_005247551                                                           19     869
XP_005247550                                                           19     869
XP_006713712                                                           19     869
XP_005247549                                                           19     869
NP_001269480                                                           16    7355
NP_001269479                                                           16    7355
NP_055777                                                              16    7355
NP_001269483                                                           16    7355
NP_001269481                                                           16    7355
NP_852108                                                              16    7355
XP_006723614                                                           16    7355
XP_006723613                                                           16    7355
XP_005260134                                                           16    7355
XP_005260133                                                           16    7355
NP_077011                                                              16    7355
NP_001041631                                                           15    9605
NP_003026                                                              15    9605
NP_001167541                                                           15    9605
NP_001013644                                                           15    9605
NP_001269867                                                           15    9605
NP_001269868                                                           15    9605
NP_001269866                                                           15    9605
NP_001269865                                                           15    9605
NP_061330                                                              15    9605
XP_006713924                                                           15    9605
XP_005248005                                                           15    9605
XP_006710897                                                           15    9605

>NP_444256
          Length = 1794

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SAETLNAK 8
           SAETLNAK
Sbjct: 930 SAETLNAK 937



>NP_444254
          Length = 1845

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SAETLNAK 8
           SAETLNAK
Sbjct: 930 SAETLNAK 937



>NP_444253
          Length = 1914

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SAETLNAK 8
            SAETLNAK
Sbjct: 999  SAETLNAK 1006



>NP_444255
          Length = 1863

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SAETLNAK 8
            SAETLNAK
Sbjct: 999  SAETLNAK 1006



>XP_005247551
          Length = 1855

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   SAETLNAK 8
           SAETLNAK
Sbjct: 940 SAETLNAK 947



>XP_005247550
          Length = 1856

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SAETLNAK 8
            SAETLNAK
Sbjct: 1009 SAETLNAK 1016



>XP_006713712
          Length = 1923

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SAETLNAK 8
            SAETLNAK
Sbjct: 1009 SAETLNAK 1016



>XP_005247549
          Length = 1924

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    SAETLNAK 8
            SAETLNAK
Sbjct: 1009 SAETLNAK 1016



>NP_001269480
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ETLNAK 8
           ETLNAK
Sbjct: 215 ETLNAK 220



>NP_001269479
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ETLNAK 8
           ETLNAK
Sbjct: 215 ETLNAK 220



>NP_055777
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ETLNAK 8
           ETLNAK
Sbjct: 276 ETLNAK 281



>NP_001269483
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ETLNAK 8
           ETLNAK
Sbjct: 125 ETLNAK 130



>NP_001269481
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ETLNAK 8
           ETLNAK
Sbjct: 125 ETLNAK 130



>NP_852108
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ETLNAK 8
           ETLNAK
Sbjct: 319 ETLNAK 324



>XP_006723614
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ETLNAK 8
           ETLNAK
Sbjct: 215 ETLNAK 220



>XP_006723613
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ETLNAK 8
           ETLNAK
Sbjct: 276 ETLNAK 281



>XP_005260134
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  ETLNAK 8
          ETLNAK
Sbjct: 30 ETLNAK 35



>XP_005260133
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ETLNAK 8
           ETLNAK
Sbjct: 234 ETLNAK 239



>NP_077011
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ETLNAK 8
           ETLNAK
Sbjct: 272 ETLNAK 277



>NP_001041631
          Length = 1288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAETLNAKT 9
           SAE+ NA+T
Sbjct: 356 SAESQNAET 364



>NP_003026
          Length = 1287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAETLNAKT 9
           SAE+ NA+T
Sbjct: 356 SAESQNAET 364



>NP_001167541
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  SAETLN 6
          SAETLN
Sbjct: 29 SAETLN 34



>NP_001013644
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  SAETLN 6
          SAETLN
Sbjct: 29 SAETLN 34



>NP_001269867
          Length = 1241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAETLNAKT 9
           SAE+ NA+T
Sbjct: 309 SAESQNAET 317



>NP_001269868
          Length = 1223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAETLNAKT 9
           SAE+ NA+T
Sbjct: 309 SAESQNAET 317



>NP_001269866
          Length = 1270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAETLNAKT 9
           SAE+ NA+T
Sbjct: 356 SAESQNAET 364



>NP_001269865
          Length = 1287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAETLNAKT 9
           SAE+ NA+T
Sbjct: 356 SAESQNAET 364



>NP_061330
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   SAETLNAK 8
           SAE LN+K
Sbjct: 214 SAELLNSK 221



>XP_006713924
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  SAETLN 6
          SAETLN
Sbjct: 29 SAETLN 34



>XP_005248005
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  SAETLN 6
          SAETLN
Sbjct: 29 SAETLN 34



>XP_006710897
          Length = 1288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   SAETLNAKT 9
           SAE+ NA+T
Sbjct: 356 SAESQNAET 364



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.283   0.0954    0.213 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 267,491
Number of extensions: 258
Number of successful extensions: 31
Number of sequences better than 10000.0: 31
Number of HSP's gapped: 31
Number of HSP's successfully gapped: 31
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)