Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1935
XP_006716142                                                           18    1935
XP_005250088                                                           18    1935
XP_006716141                                                           18    1935
XP_005250085                                                           18    1935
XP_006716140                                                           18    1935
XP_005250084                                                           18    1935
XP_005250083                                                           18    1935
XP_005250082                                                           18    1935
NP_073747                                                              16    5631
NP_001026                                                              16    5631
NP_065770                                                              16    5631
XP_006711873                                                           16    5631
XP_006711872                                                           16    5631
XP_006711871                                                           16    5631
XP_006711870                                                           16    5631
XP_006711869                                                           16    5631
XP_006711868                                                           16    5631
XP_006711867                                                           16    5631
XP_006711866                                                           16    5631
XP_006711865                                                           16    5631
XP_005271187                                                           16    5631
NP_056080                                                              16    7355
NP_001165980                                                           16    7355
NP_001165988                                                           16    7355
NP_065128                                                              16    7355
NP_001135943                                                           16    7355
NP_004710                                                              16    7355
XP_006719755                                                           16    7355
XP_005269287                                                           16    7355
XP_005263206                                                           16    7355
XP_005263205                                                           16    7355
XP_005246453                                                           16    7355
XP_006712435                                                           16    7355
NP_001268713                                                           15    9605
NP_001268710                                                           15    9605
NP_001226                                                              15    9605
NP_001193943                                                           15    9605
NP_001276881                                                           15    9605
NP_001276880                                                           15    9605
NP_001008401                                                           15    9605
XP_005253860                                                           15    9605
XP_006718792                                                           15    9605
XP_006718791                                                           15    9605
XP_006718790                                                           15    9605
>NP_733751
          Length = 4911

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           SAD SKADV
Sbjct: 773 SADISKADV 781
>XP_006716142
          Length = 4927

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           SAD SKADV
Sbjct: 774 SADISKADV 782
>XP_005250088
          Length = 4928

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           SAD SKADV
Sbjct: 774 SADISKADV 782
>XP_006716141
          Length = 4959

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           SAD SKADV
Sbjct: 774 SADISKADV 782
>XP_005250085
          Length = 4979

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           SAD SKADV
Sbjct: 774 SADISKADV 782
>XP_006716140
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           SAD SKADV
Sbjct: 774 SADISKADV 782
>XP_005250084
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           SAD SKADV
Sbjct: 774 SADISKADV 782
>XP_005250083
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           SAD SKADV
Sbjct: 773 SADISKADV 781
>XP_005250082
          Length = 4983

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           SAD SKADV
Sbjct: 774 SADISKADV 782
>NP_073747
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SADKSKAD 8
           SAD+S+AD
Sbjct: 360 SADQSQAD 367
>NP_001026
          Length = 4967

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKSKADV 9
           DK KADV
Sbjct: 318 DKEKADV 324
>NP_065770
          Length = 2036

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ADKSKADV 9
            AD+ KADV
Sbjct: 1103 ADEDKADV 1110
>XP_006711873
          Length = 4954

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKSKADV 9
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711872
          Length = 2735

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKSKADV 9
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711871
          Length = 4906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKSKADV 9
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711870
          Length = 4965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKSKADV 9
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711869
          Length = 4973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKSKADV 9
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711868
          Length = 4975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKSKADV 9
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711867
          Length = 4977

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKSKADV 9
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711866
          Length = 4984

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKSKADV 9
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_006711865
          Length = 4985

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DKSKADV 9
           DK KADV
Sbjct: 318 DKEKADV 324
>XP_005271187
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   SADKSKAD 8
           SAD+S+AD
Sbjct: 234 SADQSQAD 241
>NP_056080
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SADKSKA 7
           +ADKSKA
Sbjct: 719 NADKSKA 725
>NP_001165980
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SADKSKA 7
           +ADKSKA
Sbjct: 719 NADKSKA 725
>NP_001165988
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SADKSKA 7
           +ADKSKA
Sbjct: 719 NADKSKA 725
>NP_065128
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADKSKADV 9
           ADK K+D+
Sbjct: 101 ADKMKSDI 108
>NP_001135943
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADKSKADV 9
           ADK K+D+
Sbjct: 101 ADKMKSDI 108
>NP_004710
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    SADKSKAD 8
            SAD SK D
Sbjct: 1367 SADSSKTD 1374
>XP_006719755
          Length = 1418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    SADKSKAD 8
            SAD SK D
Sbjct: 1322 SADSSKTD 1329
>XP_005269287
          Length = 1527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    SADKSKAD 8
            SAD SK D
Sbjct: 1431 SADSSKTD 1438
>XP_005263206
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADKSKADV 9
           ADK K+D+
Sbjct: 101 ADKMKSDI 108
>XP_005263205
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ADKSKADV 9
           ADK K+D+
Sbjct: 101 ADKMKSDI 108
>XP_005246453
          Length = 675

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SADKSKA 7
           +ADKSKA
Sbjct: 661 NADKSKA 667
>XP_006712435
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   SADKSKA 7
           +ADKSKA
Sbjct: 719 NADKSKA 725
>NP_001268713
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           S D+SKA++
Sbjct: 467 STDRSKAEM 475
>NP_001268710
          Length = 1088

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   SADKSKADV 9
           S D+SKA++
Sbjct: 467 STDRSKAEM 475
>NP_001226
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DKSKADV 9
           DK+KAD+
Sbjct: 331 DKNKADL 337
>NP_001193943
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DKSKADV 9
           DK+KAD+
Sbjct: 331 DKNKADL 337
>NP_001276881
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ADKSKADV 9
           ADK K DV
Sbjct: 239 ADKYKCDV 246
>NP_001276880
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ADKSKADV 9
           ADK K DV
Sbjct: 239 ADKYKCDV 246
>NP_001008401
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ADKSKADV 9
           ADK K DV
Sbjct: 239 ADKYKCDV 246
>XP_005253860
          Length = 267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   SADKSKAD 8
           S+DKS+ D
Sbjct: 244 SSDKSRGD 251
>XP_006718792
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DKSKADV 9
           DK+KAD+
Sbjct: 331 DKNKADL 337
>XP_006718791
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DKSKADV 9
           DK+KAD+
Sbjct: 331 DKNKADL 337
>XP_006718790
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DKSKADV 9
           DK+KAD+
Sbjct: 331 DKNKADL 337
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.287    0.103    0.236 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 433,457
Number of extensions: 718
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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