Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     390
XP_006718908                                                           20     390
XP_005271621                                                           20     390
XP_006718907                                                           20     390
XP_006718906                                                           20     390
XP_005271619                                                           20     390
XP_005271618                                                           20     390
NP_598397                                                              17    4312
NP_004728                                                              17    4312
NP_203747                                                              17    4312
NP_115272                                                              17    4312
NP_061750                                                              17    4312
NP_001271324                                                           17    4312
NP_001269058                                                           17    4312
NP_064597                                                              17    4312
XP_006724438                                                           17    4312
XP_005261889                                                           17    4312
XP_005261888                                                           17    4312
XP_006722212                                                           17    4312
XP_005258116                                                           17    4312
XP_005258115                                                           17    4312
NP_997320                                                              16    5631
NP_061759                                                              16    5631
XP_005253612                                                           16    5631
NP_055507                                                              16    7355
NP_006085                                                              16    7355
NP_001157743                                                           16    7355
NP_872584                                                              16    7355
NP_061757                                                              16    7355
XP_005273432                                                           16    7355
XP_005273431                                                           16    7355
NP_001165783                                                           15    9605
NP_694984                                                              15    9605
NP_002661                                                              15    9605
NP_001138791                                                           15    9605
NP_775885                                                              15    9605
NP_001269266                                                           15    9605
NP_001269267                                                           15    9605
NP_001004060                                                           15    9605
NP_001399                                                              15    9605
NP_001165806                                                           15    9605
NP_001129497                                                           15    9605
NP_005023                                                              15    9605
NP_001004067                                                           15    9605
XP_006725258                                                           15    9605
XP_006724701                                                           15    9605
XP_005262172                                                           15    9605
XP_005262170                                                           15    9605
XP_005255375                                                           15    9605
XP_006713725                                                           15    9605
XP_006713724                                                           15    9605
XP_006713723                                                           15    9605
XP_006710468                                                           15    9605
XP_005270637                                                           15    9605
NP_055102                                                              15    9605
>NP_000042
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RYTVNVQRE 9
            RYTV VQRE
Sbjct: 2436 RYTVKVQRE 2444
>XP_006718908
          Length = 1708

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RYTVNVQRE 9
            RYTV VQRE
Sbjct: 1088 RYTVKVQRE 1096
>XP_005271621
          Length = 2708

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RYTVNVQRE 9
            RYTV VQRE
Sbjct: 2088 RYTVKVQRE 2096
>XP_006718907
          Length = 3050

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RYTVNVQRE 9
            RYTV VQRE
Sbjct: 2430 RYTVKVQRE 2438
>XP_006718906
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RYTVNVQRE 9
            RYTV VQRE
Sbjct: 2436 RYTVKVQRE 2444
>XP_005271619
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RYTVNVQRE 9
            RYTV VQRE
Sbjct: 2436 RYTVKVQRE 2444
>XP_005271618
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RYTVNVQRE 9
            RYTV VQRE
Sbjct: 2436 RYTVKVQRE 2444
>NP_598397
          Length = 756

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RYTVNVQRE 9
          RYT + QRE
Sbjct: 53 RYTASSQRE 61
>NP_004728
          Length = 756

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RYTVNVQRE 9
          RYT + QRE
Sbjct: 53 RYTASSQRE 61
>NP_203747
          Length = 1423

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RYTVNVQRE 9
           RY +NV RE
Sbjct: 335 RYILNVTRE 343
>NP_115272
          Length = 808

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RYTVNVQ 7
           RYT+N++
Sbjct: 314 RYTINIE 320
>NP_061750
          Length = 929

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RYTVNVQ 7
           RYT+N++
Sbjct: 314 RYTINIE 320
>NP_001271324
          Length = 658

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RYTVNVQRE 9
           RY++++QRE
Sbjct: 646 RYSLSLQRE 654
>NP_001269058
          Length = 1450

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RYTVNVQRE 9
           RY +NV RE
Sbjct: 362 RYILNVTRE 370
>NP_064597
          Length = 686

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RYTVNVQRE 9
           RY++++QRE
Sbjct: 674 RYSLSLQRE 682
>XP_006724438
          Length = 577

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RYTVNVQRE 9
          RYT + QRE
Sbjct: 53 RYTASSQRE 61
>XP_005261889
          Length = 756

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RYTVNVQRE 9
          RYT + QRE
Sbjct: 53 RYTASSQRE 61
>XP_005261888
          Length = 756

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RYTVNVQRE 9
          RYT + QRE
Sbjct: 53 RYTASSQRE 61
>XP_006722212
          Length = 1401

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RYTVNVQRE 9
           RY +NV RE
Sbjct: 313 RYILNVTRE 321
>XP_005258116
          Length = 1430

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RYTVNVQRE 9
           RY +NV RE
Sbjct: 342 RYILNVTRE 350
>XP_005258115
          Length = 1450

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RYTVNVQRE 9
           RY +NV RE
Sbjct: 362 RYILNVTRE 370
>NP_997320
          Length = 4471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RYTVNVQR 8
           RYT  +QR
Sbjct: 703 RYTAGIQR 710
>NP_061759
          Length = 798

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   YTVNVQ 7
           YTVN+Q
Sbjct: 317 YTVNIQ 322
>XP_005253612
          Length = 4589

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RYTVNVQR 8
           RYT  +QR
Sbjct: 821 RYTAGIQR 828
>NP_055507
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RYTVNVQR 8
           +YT NV+R
Sbjct: 151 QYTANVKR 158
>NP_006085
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TVNVQR 8
           TVNVQR
Sbjct: 644 TVNVQR 649
>NP_001157743
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TVNVQR 8
           TVNVQR
Sbjct: 570 TVNVQR 575
>NP_872584
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TVNVQR 8
            TVNVQR
Sbjct: 1081 TVNVQR 1086
>NP_061757
          Length = 798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   YTVNVQ 7
           YT+N+Q
Sbjct: 315 YTINIQ 320
>XP_005273432
          Length = 1125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TVNVQR 8
           TVNVQR
Sbjct: 678 TVNVQR 683
>XP_005273431
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3    TVNVQR 8
            TVNVQR
Sbjct: 1081 TVNVQR 1086
>NP_001165783
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 502 RYTLNV 507
>NP_694984
          Length = 1802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YTVNVQRE 9
           Y+VN+Q++
Sbjct: 966 YSVNLQKQ 973
>NP_002661
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 502 RYTLNV 507
>NP_001138791
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 502 RYTLNV 507
>NP_775885
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YTVNVQRE 9
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
>NP_001269266
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 491 RYTLNV 496
>NP_001269267
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 459 RYTLNV 464
>NP_001004060
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YTVNVQRE 9
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
>NP_001399
          Length = 2923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YTVNVQRE 9
           YTVNV  +
Sbjct: 717 YTVNVNED 724
>NP_001165806
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 477 RYTLNV 482
>NP_001129497
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 504 RYTLNV 509
>NP_005023
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 504 RYTLNV 509
>NP_001004067
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YTVNVQRE 9
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
>XP_006725258
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YTVNVQRE 9
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
>XP_006724701
          Length = 1398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YTVNVQRE 9
           Y+VN+Q++
Sbjct: 562 YSVNLQKQ 569
>XP_005262172
          Length = 1631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YTVNVQRE 9
           Y+VN+Q++
Sbjct: 795 YSVNLQKQ 802
>XP_005262170
          Length = 1752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   YTVNVQRE 9
           Y+VN+Q++
Sbjct: 916 YSVNLQKQ 923
>XP_005255375
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YTVNVQRE 9
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
>XP_006713725
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 502 RYTLNV 507
>XP_006713724
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 502 RYTLNV 507
>XP_006713723
          Length = 629

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RYTVNV 6
           RYT+NV
Sbjct: 502 RYTLNV 507
>XP_006710468
          Length = 2916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YTVNVQRE 9
           YTVNV  +
Sbjct: 717 YTVNVNED 724
>XP_005270637
          Length = 2921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   YTVNVQRE 9
           YTVNV  +
Sbjct: 717 YTVNVNED 724
>NP_055102
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   YTVNVQRE 9
           YT++ Q+E
Sbjct: 375 YTIHAQKE 382
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.129    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 440,984
Number of extensions: 617
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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