Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           18    1935
NP_001185763                                                           18    1935
NP_055459                                                              18    1935
XP_006726410                                                           18    1935
XP_006711719                                                           18    1935
XP_006711718                                                           18    1935
XP_006711717                                                           18    1935
XP_006711716                                                           18    1935
XP_006711715                                                           18    1935
XP_006711714                                                           18    1935
XP_006711713                                                           18    1935
XP_006711712                                                           18    1935
XP_006711711                                                           18    1935
XP_006711710                                                           18    1935
XP_006711709                                                           18    1935
XP_005277503                                                           18    1935
XP_005273038                                                           18    1935
XP_006711708                                                           18    1935
XP_005277500                                                           18    1935
XP_006711707                                                           18    1935
XP_005277499                                                           18    1935
XP_006711706                                                           18    1935
XP_006711705                                                           18    1935
XP_006711164                                                           18    1935
XP_006710143                                                           18    1935
XP_006710142                                                           18    1935
XP_006710141                                                           18    1935
XP_006726897                                                           17    2528
XP_005276689                                                           17    2528
XP_006724471                                                           17    2528
XP_005257970                                                           17    2528
XP_006710181                                                           17    2528
XP_005257087                                                           17    4312
XP_005257086                                                           17    4312
NP_694941                                                              17    4312
NP_004662                                                              16    7355
NP_775298                                                              16    7355
NP_114432                                                              16    7355
NP_001099010                                                           16    7355
NP_065810                                                              16    7355
XP_006722636                                                           16    7355
XP_005258440                                                           16    7355
XP_005258439                                                           16    7355
XP_005258438                                                           16    7355
XP_005258436                                                           16    7355
XP_005258434                                                           16    7355
XP_006722635                                                           16    7355
XP_006722634                                                           16    7355
XP_006720684                                                           16    7355
XP_006718417                                                           16    7355
XP_005253237                                                           16    7355
XP_005253236                                                           16    7355
NP_115811                                                              15    9605
NP_115691                                                              15    9605
NP_542416                                                              15    9605
NP_542414                                                              15    9605
NP_006255                                                              15    9605
NP_057137                                                              15    9605
NP_001092688                                                           15    9605
NP_001010924                                                           15    9605
NP_065770                                                              15    9605
XP_005268997                                                           15    9605
XP_005268996                                                           15    9605
XP_005263224                                                           15    9605
XP_005262682                                                           15    9605
>NP_001185761
          Length = 2240

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1334 RVRSLSVTS 1342
>NP_001185763
          Length = 2362

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1378 RVRSLSVTS 1386
>NP_055459
          Length = 2346

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1378 RVRSLSVTS 1386
>XP_006726410
          Length = 2087

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1181 RVRSLSVTS 1189
>XP_006711719
          Length = 2302

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1334 RVRSLSVTS 1342
>XP_006711718
          Length = 1436

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRPLSVTS 9
           RVR LSVTS
Sbjct: 385 RVRSLSVTS 393
>XP_006711717
          Length = 2385

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1334 RVRSLSVTS 1342
>XP_006711716
          Length = 2411

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1443 RVRSLSVTS 1451
>XP_006711715
          Length = 2428

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1377 RVRSLSVTS 1385
>XP_006711714
          Length = 2429

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1378 RVRSLSVTS 1386
>XP_006711713
          Length = 2432

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1381 RVRSLSVTS 1389
>XP_006711712
          Length = 2473

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1541 RVRSLSVTS 1549
>XP_006711711
          Length = 2482

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1431 RVRSLSVTS 1439
>XP_006711710
          Length = 2494

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1443 RVRSLSVTS 1451
>XP_006711709
          Length = 2495

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1444 RVRSLSVTS 1452
>XP_005277503
          Length = 2498

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1541 RVRSLSVTS 1549
>XP_005273038
          Length = 2509

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1541 RVRSLSVTS 1549
>XP_006711708
          Length = 2512

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1541 RVRSLSVTS 1549
>XP_005277500
          Length = 2525

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1541 RVRSLSVTS 1549
>XP_006711707
          Length = 2553

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1541 RVRSLSVTS 1549
>XP_005277499
          Length = 2561

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1541 RVRSLSVTS 1549
>XP_006711706
          Length = 2591

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1540 RVRSLSVTS 1548
>XP_006711705
          Length = 2592

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1541 RVRSLSVTS 1549
>XP_006711164
          Length = 2087

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVRPLSVTS 9
            RVR LSVTS
Sbjct: 1181 RVRSLSVTS 1189
>XP_006710143
          Length = 562

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRPLSVTS 9
           RVR LSVTS
Sbjct: 220 RVRSLSVTS 228
>XP_006710142
          Length = 671

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRPLSVTS 9
           RVR LSVTS
Sbjct: 329 RVRSLSVTS 337
>XP_006710141
          Length = 672

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRPLSVTS 9
           RVR LSVTS
Sbjct: 330 RVRSLSVTS 338
>XP_006726897
          Length = 313

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RVRPLSVTS 9
          RVRPL V S
Sbjct: 61 RVRPLEVVS 69
>XP_005276689
          Length = 224

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RVRPLSVTS 9
          R RPL VTS
Sbjct: 45 RARPLPVTS 53
>XP_006724471
          Length = 313

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RVRPLSVTS 9
          RVRPL V S
Sbjct: 61 RVRPLEVVS 69
>XP_005257970
          Length = 224

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RVRPLSVTS 9
          R RPL VTS
Sbjct: 45 RARPLPVTS 53
>XP_006710181
          Length = 313

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RVRPLSVTS 9
          RVRPL V S
Sbjct: 61 RVRPLEVVS 69
>XP_005257087
          Length = 957

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RVRPLSV 7
          RVRP+SV
Sbjct: 17 RVRPISV 23
>XP_005257086
          Length = 999

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RVRPLSV 7
          RVRP+SV
Sbjct: 17 RVRPISV 23
>NP_694941
          Length = 998

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RVRPLSV 7
          RVRP+SV
Sbjct: 17 RVRPISV 23
>NP_004662
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RPLSVTS 9
           RPL++TS
Sbjct: 259 RPLNITS 265
>NP_775298
          Length = 572

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RPLSVTS 9
           RPL++TS
Sbjct: 259 RPLNITS 265
>NP_114432
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RVRPLSVT 8
           R+RPL  T
Sbjct: 160 RIRPLETT 167
>NP_001099010
          Length = 1117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RVRPLS 6
           RVRPLS
Sbjct: 216 RVRPLS 221
>NP_065810
          Length = 4700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RVRPLS 6
          RVRPLS
Sbjct: 9  RVRPLS 14
>XP_006722636
          Length = 611

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RPLSVTS 9
           RPL++TS
Sbjct: 298 RPLNITS 304
>XP_005258440
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RPLSVTS 9
           RPL++TS
Sbjct: 250 RPLNITS 256
>XP_005258439
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RPLSVTS 9
           RPL++TS
Sbjct: 250 RPLNITS 256
>XP_005258438
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RPLSVTS 9
           RPL++TS
Sbjct: 250 RPLNITS 256
>XP_005258436
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RPLSVTS 9
           RPL++TS
Sbjct: 259 RPLNITS 265
>XP_005258434
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RPLSVTS 9
           RPL++TS
Sbjct: 263 RPLNITS 269
>XP_006722635
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RPLSVTS 9
           RPL++TS
Sbjct: 298 RPLNITS 304
>XP_006722634
          Length = 661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RPLSVTS 9
           RPL++TS
Sbjct: 298 RPLNITS 304
>XP_006720684
          Length = 4713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RVRPLS 6
          RVRPLS
Sbjct: 9  RVRPLS 14
>XP_006718417
          Length = 1118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RVRPLS 6
           RVRPLS
Sbjct: 216 RVRPLS 221
>XP_005253237
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RVRPLS 6
           RVRPLS
Sbjct: 259 RVRPLS 264
>XP_005253236
          Length = 1161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RVRPLS 6
           RVRPLS
Sbjct: 259 RVRPLS 264
>NP_115811
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RVRPLS 6
           R+RPLS
Sbjct: 609 RIRPLS 614
>NP_115691
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  VRPLSVT 8
          VRP SVT
Sbjct: 65 VRPTSVT 71
>NP_542416
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VRPLSV 7
           VRPLSV
Sbjct: 922 VRPLSV 927
>NP_542414
          Length = 2485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VRPLSV 7
           VRPLSV
Sbjct: 922 VRPLSV 927
>NP_006255
          Length = 2466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VRPLSV 7
           VRPLSV
Sbjct: 922 VRPLSV 927
>NP_057137
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VRPLSVTS 9
          V PL+VTS
Sbjct: 86 VSPLNVTS 93
>NP_001092688
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RVRPLSVTS 9
            RVRPL   S
Sbjct: 1119 RVRPLKTCS 1127
>NP_001010924
          Length = 890

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   PLSVTS 9
           PLSVTS
Sbjct: 376 PLSVTS 381
>NP_065770
          Length = 2036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    RVRPLSV 7
            R+RPL V
Sbjct: 1175 RIRPLEV 1181
>XP_005268997
          Length = 161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VRPLSVTS 9
          V PL+VTS
Sbjct: 53 VSPLNVTS 60
>XP_005268996
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VRPLSVTS 9
          V PL+VTS
Sbjct: 86 VSPLNVTS 93
>XP_005263224
          Length = 2491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VRPLSV 7
           VRPLSV
Sbjct: 928 VRPLSV 933
>XP_005262682
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RVRPLSVTS 9
            RVRPL   S
Sbjct: 1110 RVRPLKTCS 1118
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.127    0.335 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 513,321
Number of extensions: 676
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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