Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     869
NP_001263689                                                           19     869
NP_001119584                                                           19     869
NP_001119586                                                           19     869
NP_001263625                                                           19     869
NP_001119590                                                           19     869
NP_001263690                                                           19     869
NP_001119585                                                           19     869
NP_001263624                                                           19     869
NP_001119588                                                           19     869
NP_001119587                                                           19     869
NP_001119589                                                           19     869
NP_055178                                                              16    5631
NP_001264984                                                           16    5631
XP_006726697                                                           16    5631
XP_005266395                                                           16    5631
NP_079390                                                              16    7355
NP_060021                                                              16    7355
NP_114127                                                              16    7355
NP_112181                                                              16    7355
NP_060658                                                              16    7355
NP_001164007                                                           16    7355
NP_001164006                                                           16    7355
NP_001004753                                                           16    7355
XP_006719673                                                           16    7355
XP_005269218                                                           16    7355
XP_005269217                                                           16    7355
XP_006719672                                                           16    7355
XP_005269215                                                           16    7355
XP_006717867                                                           16    7355
XP_005244865                                                           16    7355
XP_005244863                                                           16    7355
XP_006710514                                                           16    7355
NP_001034300                                                           16    7355
NP_001626                                                              15    9605
NP_647477                                                              15    9605
XP_005269821                                                           15    9605
XP_006715753                                                           15    9605
XP_006715752                                                           15    9605
NP_001121687                                                           15    9605
>NP_000537
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           RVR MAIYK
Sbjct: 156 RVRAMAIYK 164
>NP_001263689
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           RVR MAIYK
Sbjct: 117 RVRAMAIYK 125
>NP_001119584
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           RVR MAIYK
Sbjct: 156 RVRAMAIYK 164
>NP_001119586
          Length = 341

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           RVR MAIYK
Sbjct: 156 RVRAMAIYK 164
>NP_001263625
          Length = 302

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           RVR MAIYK
Sbjct: 117 RVRAMAIYK 125
>NP_001119590
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           RVR MAIYK
Sbjct: 117 RVRAMAIYK 125
>NP_001263690
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           RVR MAIYK
Sbjct: 117 RVRAMAIYK 125
>NP_001119585
          Length = 346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           RVR MAIYK
Sbjct: 156 RVRAMAIYK 164
>NP_001263624
          Length = 307

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           RVR MAIYK
Sbjct: 117 RVRAMAIYK 125
>NP_001119588
          Length = 209

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RVRDMAIYK 9
          RVR MAIYK
Sbjct: 24 RVRAMAIYK 32
>NP_001119587
          Length = 261

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RVRDMAIYK 9
          RVR MAIYK
Sbjct: 24 RVRAMAIYK 32
>NP_001119589
          Length = 214

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RVRDMAIYK 9
          RVR MAIYK
Sbjct: 24 RVRAMAIYK 32
>NP_055178
          Length = 4579

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VRDMAIY 8
            VRD+A+Y
Sbjct: 3902 VRDLALY 3908
>NP_001264984
          Length = 4432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VRDMAIY 8
            VRD+A+Y
Sbjct: 3755 VRDLALY 3761
>XP_006726697
          Length = 359

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RVRDMAIY 8
           R  DMA+Y
Sbjct: 317 RAEDMAVY 324
>XP_005266395
          Length = 4588

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    VRDMAIY 8
            VRD+A+Y
Sbjct: 3911 VRDLALY 3917
>NP_079390
          Length = 2479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           R ++MAI+K
Sbjct: 937 RFKEMAIFK 945
>NP_060021
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRDMAIYK 9
           VRD A+Y+
Sbjct: 682 VRDSAVYE 689
>NP_114127
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RVRDMAI 7
           RVRD+AI
Sbjct: 327 RVRDIAI 333
>NP_112181
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VRDMAIY 8
           VRD+A+Y
Sbjct: 605 VRDVALY 611
>NP_060658
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RVRDMAI 7
           RVRD+AI
Sbjct: 375 RVRDIAI 381
>NP_001164007
          Length = 507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RVRDMAI 7
           RVRD+AI
Sbjct: 248 RVRDIAI 254
>NP_001164006
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RVRDMAI 7
           RVRD+AI
Sbjct: 327 RVRDIAI 333
>NP_001004753
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRDMAIYK 9
           +RD AIY+
Sbjct: 335 IRDKAIYE 342
>XP_006719673
          Length = 1997

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           R ++MAI+K
Sbjct: 455 RFKEMAIFK 463
>XP_005269218
          Length = 2009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           R ++MAI+K
Sbjct: 467 RFKEMAIFK 475
>XP_005269217
          Length = 2353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           R ++MAI+K
Sbjct: 968 RFKEMAIFK 976
>XP_006719672
          Length = 2510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           R ++MAI+K
Sbjct: 968 RFKEMAIFK 976
>XP_005269215
          Length = 2510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVRDMAIYK 9
           R ++MAI+K
Sbjct: 968 RFKEMAIFK 976
>XP_006717867
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRDMAIYK 9
           VRD A+Y+
Sbjct: 682 VRDSAVYE 689
>XP_005244865
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RVRDMAI 7
           RVRD+AI
Sbjct: 327 RVRDIAI 333
>XP_005244863
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RVRDMAI 7
           RVRD+AI
Sbjct: 327 RVRDIAI 333
>XP_006710514
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RVRDMAI 7
           RVRD+AI
Sbjct: 151 RVRDIAI 157
>NP_001034300
          Length = 411

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RVRDMAI 7
           RVRD+AI
Sbjct: 152 RVRDIAI 158
>NP_001626
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RDMAIYK 9
           RD+A YK
Sbjct: 677 RDLATYK 683
>NP_647477
          Length = 653

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RDMAIYK 9
           RD+A YK
Sbjct: 635 RDLATYK 641
>XP_005269821
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RVRDMAI 7
           RVRDM +
Sbjct: 316 RVRDMTV 322
>XP_006715753
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RDMAIYK 9
           RD+A YK
Sbjct: 801 RDLATYK 807
>XP_006715752
          Length = 1225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RDMAIYK 9
            RD+A YK
Sbjct: 1207 RDLATYK 1213
>NP_001121687
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RVRDMAI 7
           RVRDM +
Sbjct: 341 RVRDMTV 347
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.339    0.145    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 388,970
Number of extensions: 599
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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