Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     665
NP_001263689                                                           19     665
NP_001119584                                                           19     665
NP_001119586                                                           19     665
NP_001263625                                                           19     665
NP_001119590                                                           19     665
NP_001263690                                                           19     665
NP_001119585                                                           19     665
NP_001263624                                                           19     665
NP_001119588                                                           19     665
NP_001119587                                                           19     665
NP_001119589                                                           19     665
NP_001164663                                                           15    9605
NP_859051                                                              15    9605
NP_859050                                                              15    9605
NP_002707                                                              15    9605
NP_001171033                                                           15    9605
XP_006718935                                                           15    9605
XP_006718934                                                           15    9605
XP_006718933                                                           15    9605
XP_006718932                                                           15    9605
XP_006718931                                                           15    9605
XP_006718930                                                           15    9605
NP_001171034                                                           15    9605
>NP_000537
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVRAMAIHK 9
           RVRAMAI+K
Sbjct: 156 RVRAMAIYK 164
>NP_001263689
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVRAMAIHK 9
           RVRAMAI+K
Sbjct: 117 RVRAMAIYK 125
>NP_001119584
          Length = 393

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVRAMAIHK 9
           RVRAMAI+K
Sbjct: 156 RVRAMAIYK 164
>NP_001119586
          Length = 341

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVRAMAIHK 9
           RVRAMAI+K
Sbjct: 156 RVRAMAIYK 164
>NP_001263625
          Length = 302

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVRAMAIHK 9
           RVRAMAI+K
Sbjct: 117 RVRAMAIYK 125
>NP_001119590
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVRAMAIHK 9
           RVRAMAI+K
Sbjct: 117 RVRAMAIYK 125
>NP_001263690
          Length = 354

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVRAMAIHK 9
           RVRAMAI+K
Sbjct: 117 RVRAMAIYK 125
>NP_001119585
          Length = 346

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVRAMAIHK 9
           RVRAMAI+K
Sbjct: 156 RVRAMAIYK 164
>NP_001263624
          Length = 307

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVRAMAIHK 9
           RVRAMAI+K
Sbjct: 117 RVRAMAIYK 125
>NP_001119588
          Length = 209

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  RVRAMAIHK 9
          RVRAMAI+K
Sbjct: 24 RVRAMAIYK 32
>NP_001119587
          Length = 261

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  RVRAMAIHK 9
          RVRAMAI+K
Sbjct: 24 RVRAMAIYK 32
>NP_001119589
          Length = 214

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  RVRAMAIHK 9
          RVRAMAI+K
Sbjct: 24 RVRAMAIYK 32
>NP_001164663
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AMAIHK 9
           AMA+HK
Sbjct: 486 AMALHK 491
>NP_859051
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 246 VRAAAAHK 253
>NP_859050
          Length = 667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 310 VRAAAAHK 317
>NP_002707
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 310 VRAAAAHK 317
>NP_001171033
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 310 VRAAAAHK 317
>XP_006718935
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 397 VRAAAAHK 404
>XP_006718934
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 397 VRAAAAHK 404
>XP_006718933
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 397 VRAAAAHK 404
>XP_006718932
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 397 VRAAAAHK 404
>XP_006718931
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 397 VRAAAAHK 404
>XP_006718930
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 397 VRAAAAHK 404
>NP_001171034
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VRAMAIHK 9
           VRA A HK
Sbjct: 183 VRAAAAHK 190
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.344    0.135    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 369,151
Number of extensions: 400
Number of successful extensions: 24
Number of sequences better than 10000.0: 24
Number of HSP's gapped: 24
Number of HSP's successfully gapped: 24
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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