Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              19     665
NP_663696                                                              19     869
XP_006726859                                                           17    3301
XP_006723959                                                           17    3301
NP_001157916                                                           16    5631
XP_006714976                                                           16    5631
NP_002987                                                              16    7355
NP_078966                                                              16    7355
NP_653252                                                              16    7355
NP_071733                                                              16    7355
NP_778228                                                              16    7355
XP_006723004                                                           16    7355
XP_006720785                                                           16    7355
XP_005274110                                                           16    7355
XP_005252859                                                           16    7355
XP_006718216                                                           16    7355
XP_006718215                                                           16    7355
XP_006718214                                                           16    7355
XP_006718213                                                           16    7355
XP_006718212                                                           16    7355
XP_005251225                                                           16    7355
XP_006716483                                                           16    7355
XP_005251224                                                           16    7355
NP_115821                                                              16    7355
NP_689777                                                              15    9605
NP_060360                                                              15    9605
NP_056058                                                              15    9605
NP_001242935                                                           15    9605
NP_001091059                                                           15    9605
NP_001252530                                                           15    9605
NP_061862                                                              15    9605
NP_892117                                                              15    9605
NP_001139734                                                           15    9605
NP_001139733                                                           15    9605
NP_694994                                                              15    9605
NP_001139736                                                           15    9605
NP_006405                                                              15    9605
XP_006717427                                                           15    9605
XP_006717426                                                           15    9605
XP_006716574                                                           15    9605
XP_006716573                                                           15    9605
XP_005250858                                                           15    9605
XP_005250857                                                           15    9605
XP_006715622                                                           15    9605
XP_005267190                                                           15    9605
XP_005267189                                                           15    9605
XP_005267187                                                           15    9605
XP_005267185                                                           15    9605
XP_005267184                                                           15    9605
XP_005268525                                                           15    9605
XP_005268524                                                           15    9605
XP_006714850                                                           15    9605
XP_005268523                                                           15    9605
XP_006711326                                                           15    9605
XP_005273145                                                           15    9605
XP_006711325                                                           15    9605
NP_009055                                                              15    9605
>NP_115803
          Length = 1156

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVPSLSTAV 9
           R+PSLSTAV
Sbjct: 856 RMPSLSTAV 864
>NP_663696
          Length = 615

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RVPSLSTA 8
           RVPSLSTA
Sbjct: 557 RVPSLSTA 564
>XP_006726859
          Length = 336

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  RVPSLSTAV 9
          R PSLS+AV
Sbjct: 75 RCPSLSSAV 83

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RVPSLSTAV 9
          R PSLS+A+
Sbjct: 35 RCPSLSSAL 43

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RVPSLSTAV 9
           R PSLS+A+
Sbjct: 95  RCPSLSSAL 103
>XP_006723959
          Length = 336

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  RVPSLSTAV 9
          R PSLS+AV
Sbjct: 75 RCPSLSSAV 83

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RVPSLSTAV 9
           R PSLS+A+
Sbjct: 95  RCPSLSSAL 103
>NP_001157916
          Length = 242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RVPSLST 7
           R+PSLST
Sbjct: 97  RMPSLST 103
>XP_006714976
          Length = 241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RVPSLST 7
           R+PSLST
Sbjct: 96  RMPSLST 102
>NP_002987
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RVPSLSTA 8
           RVP +STA
Sbjct: 187 RVPPVSTA 194
>NP_078966
          Length = 14507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1     RVPSLST 7
             +VPSLST
Sbjct: 10415 QVPSLST 10421
>NP_653252
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VP+LSTA
Sbjct: 818 VPALSTA 824
>NP_071733
          Length = 449

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSLSTAV 9
           PSLSTA+
Sbjct: 186 PSLSTAL 192
>NP_778228
          Length = 1121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VPSLST+
Sbjct: 852 VPSLSTS 858
>XP_006723004
          Length = 6443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    RVPSLST 7
            +VPSLST
Sbjct: 2329 QVPSLST 2335
>XP_006720785
          Length = 1079

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    VPSLSTA 8
            VPSLST+
Sbjct: 1013 VPSLSTS 1019
>XP_005274110
          Length = 449

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   PSLSTAV 9
           PSLSTA+
Sbjct: 186 PSLSTAL 192
>XP_005252859
          Length = 1272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VPSLST+
Sbjct: 852 VPSLSTS 858
>XP_006718216
          Length = 1298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VPSLST+
Sbjct: 852 VPSLSTS 858
>XP_006718215
          Length = 1325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VPSLST+
Sbjct: 879 VPSLSTS 885
>XP_006718214
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VPSLST+
Sbjct: 892 VPSLSTS 898
>XP_006718213
          Length = 1339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VPSLST+
Sbjct: 919 VPSLSTS 925
>XP_006718212
          Length = 1365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VPSLST+
Sbjct: 919 VPSLSTS 925
>XP_005251225
          Length = 848

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VP+LSTA
Sbjct: 203 VPALSTA 209
>XP_006716483
          Length = 1367

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VP+LSTA
Sbjct: 722 VPALSTA 728
>XP_005251224
          Length = 1439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VP+LSTA
Sbjct: 794 VPALSTA 800
>NP_115821
          Length = 1044

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VPSLSTA 8
           VPSLST+
Sbjct: 978 VPSLSTS 984
>NP_689777
          Length = 3997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           +PS STA+
Sbjct: 760 IPSFSTAL 767
>NP_060360
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           +PS STA+
Sbjct: 760 IPSFSTAL 767
>NP_056058
          Length = 863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           +PS STA+
Sbjct: 760 IPSFSTAL 767
>NP_001242935
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           VPS STAV
Sbjct: 189 VPSDSTAV 196
>NP_001091059
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RVPSLS 6
           RVPSLS
Sbjct: 199 RVPSLS 204
>NP_001252530
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RVPSLS 6
           RVPSLS
Sbjct: 199 RVPSLS 204
>NP_061862
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RVPSLST 7
            +VPS+ST
Sbjct: 1017 KVPSIST 1023
>NP_892117
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RVPSLS 6
           RVPSLS
Sbjct: 199 RVPSLS 204
>NP_001139734
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           VPS STAV
Sbjct: 227 VPSDSTAV 234
>NP_001139733
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           VPS STAV
Sbjct: 272 VPSDSTAV 279
>NP_694994
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           VPS STAV
Sbjct: 227 VPSDSTAV 234
>NP_001139736
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           VPS STAV
Sbjct: 272 VPSDSTAV 279
>NP_006405
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RVPSLS 6
           RVPSLS
Sbjct: 199 RVPSLS 204
>XP_006717427
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RVPSLS 6
           RVPSLS
Sbjct: 199 RVPSLS 204
>XP_006717426
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RVPSLS 6
           RVPSLS
Sbjct: 199 RVPSLS 204
>XP_006716574
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           +PS STA+
Sbjct: 760 IPSFSTAL 767
>XP_006716573
          Length = 1776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           +PS STA+
Sbjct: 760 IPSFSTAL 767
>XP_005250858
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           +PS STA+
Sbjct: 760 IPSFSTAL 767
>XP_005250857
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           +PS STA+
Sbjct: 760 IPSFSTAL 767
>XP_006715622
          Length = 2499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           VP L+TA+
Sbjct: 958 VPELNTAI 965
>XP_005267190
          Length = 3424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VPSLSTAV 9
            VP L+TA+
Sbjct: 1883 VPELNTAI 1890
>XP_005267189
          Length = 3425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VPSLSTAV 9
            VP L+TA+
Sbjct: 1897 VPELNTAI 1904
>XP_005267187
          Length = 3433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VPSLSTAV 9
            VP L+TA+
Sbjct: 1892 VPELNTAI 1899
>XP_005267185
          Length = 3437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VPSLSTAV 9
            VP L+TA+
Sbjct: 1896 VPELNTAI 1903
>XP_005267184
          Length = 3438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VPSLSTAV 9
            VP L+TA+
Sbjct: 1897 VPELNTAI 1904
>XP_005268525
          Length = 1005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RVPSLST 7
           +VPS+ST
Sbjct: 962 KVPSIST 968
>XP_005268524
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RVPSLST 7
           +VPS+ST
Sbjct: 963 KVPSIST 969
>XP_006714850
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RVPSLST 7
            +VPS+ST
Sbjct: 1006 KVPSIST 1012
>XP_005268523
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    RVPSLST 7
            +VPS+ST
Sbjct: 1018 KVPSIST 1024
>XP_006711326
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           VPS STAV
Sbjct: 517 VPSDSTAV 524
>XP_005273145
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           VPS STAV
Sbjct: 517 VPSDSTAV 524
>XP_006711325
          Length = 864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VPSLSTAV 9
           VPS STAV
Sbjct: 517 VPSDSTAV 524
>NP_009055
          Length = 3433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VPSLSTAV 9
            VP L+TA+
Sbjct: 1892 VPELNTAI 1899
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.119    0.303 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 585,138
Number of extensions: 716
Number of successful extensions: 60
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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