Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              17    2528
NP_001075109                                                           17    2528
NP_009187                                                              17    2528
XP_006718490                                                           17    2528
NP_001138684                                                           17    2528
NP_001138683                                                           17    2528
NP_443111                                                              16    5631
NP_003466                                                              16    5631
NP_954660                                                              16    5631
NP_954658                                                              16    5631
NP_001137465                                                           16    5631
NP_001164274                                                           16    5631
XP_005253208                                                           16    5631
XP_006725209                                                           16    5631
XP_006725208                                                           16    5631
XP_006725207                                                           16    5631
XP_006725206                                                           16    5631
XP_006725205                                                           16    5631
XP_005268670                                                           16    5631
XP_006719278                                                           16    5631
XP_006718401                                                           16    5631
XP_006718400                                                           16    5631
XP_005253207                                                           16    5631
XP_005253206                                                           16    5631
XP_005253205                                                           16    5631
XP_005253204                                                           16    5631
NP_001164279                                                           16    5631
NP_001137466                                                           16    5631
NP_061871                                                              16    7355
NP_055791                                                              16    7355
XP_005269704                                                           16    7355
XP_005266147                                                           16    7355
XP_005266146                                                           16    7355
NP_001257438                                                           15    9605
NP_001243054                                                           15    9605
NP_002817                                                              15    9605
NP_001004128                                                           15    9605
NP_003456                                                              15    9605
NP_001244930                                                           15    9605
NP_970615                                                              15    9605
NP_001161771                                                           15    9605
NP_001244932                                                           15    9605
NP_068569                                                              15    9605
NP_002018                                                              15    9605
>NP_008835
          Length = 4128

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVLVQTLRE 9
            RVLVQTL E
Sbjct: 1370 RVLVQTLCE 1378
>NP_001075109
          Length = 4097

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RVLVQTLRE 9
            RVLVQTL E
Sbjct: 1370 RVLVQTLCE 1378
>NP_009187
          Length = 709

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RVLVQTLR 8
           RVL+QTLR
Sbjct: 362 RVLLQTLR 369
>XP_006718490
          Length = 635

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RVLVQTLR 8
           RVL+QTLR
Sbjct: 362 RVLLQTLR 369
>NP_001138684
          Length = 565

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RVLVQTLR 8
           RVL+QTLR
Sbjct: 218 RVLLQTLR 225
>NP_001138683
          Length = 687

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RVLVQTLR 8
           RVL+QTLR
Sbjct: 340 RVLLQTLR 347
>NP_443111
          Length = 724

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 633 VLVQPLRE 640
>NP_003466
          Length = 373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ LRE
Sbjct: 48 VLVQRLRE 55
>NP_954660
          Length = 653

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 562 VLVQPLRE 569
>NP_954658
          Length = 723

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 632 VLVQPLRE 639
>NP_001137465
          Length = 337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ LRE
Sbjct: 48 VLVQRLRE 55
>NP_001164274
          Length = 582

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 491 VLVQPLRE 498
>XP_005253208
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ LRE
Sbjct: 48 VLVQRLRE 55
>XP_006725209
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ LRE
Sbjct: 48 VLVQRLRE 55
>XP_006725208
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ LRE
Sbjct: 48 VLVQRLRE 55
>XP_006725207
          Length = 387

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 115 VLVQRLRE 122
>XP_006725206
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 115 VLVQRLRE 122
>XP_006725205
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 115 VLVQRLRE 122
>XP_005268670
          Length = 654

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 563 VLVQPLRE 570
>XP_006719278
          Length = 670

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 579 VLVQPLRE 586
>XP_006718401
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ LRE
Sbjct: 48 VLVQRLRE 55
>XP_006718400
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ LRE
Sbjct: 48 VLVQRLRE 55
>XP_005253207
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ LRE
Sbjct: 48 VLVQRLRE 55
>XP_005253206
          Length = 387

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 115 VLVQRLRE 122
>XP_005253205
          Length = 440

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 115 VLVQRLRE 122
>XP_005253204
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 115 VLVQRLRE 122
>NP_001164279
          Length = 653

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ LRE
Sbjct: 562 VLVQPLRE 569
>NP_001137466
          Length = 320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ LRE
Sbjct: 48 VLVQRLRE 55
>NP_061871
          Length = 566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          V VQTLRE
Sbjct: 83 VEVQTLRE 90
>NP_055791
          Length = 1871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VL+QTL E
Sbjct: 835 VLIQTLAE 842
>XP_005269704
          Length = 1872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VL+QTL E
Sbjct: 835 VLIQTLAE 842
>XP_005266147
          Length = 658

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           V VQTLRE
Sbjct: 175 VEVQTLRE 182
>XP_005266146
          Length = 668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           V VQTLRE
Sbjct: 175 VEVQTLRE 182
>NP_001257438
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQTLRE 9
           L+QTLR+
Sbjct: 332 LIQTLRQ 338
>NP_001243054
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQTLRE 9
           L+QTLR+
Sbjct: 358 LIQTLRQ 364
>NP_002817
          Length = 747

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VQTLRE 9
           VQTLRE
Sbjct: 143 VQTLRE 148
>NP_001004128
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VQTLRE 9
           VQTLRE
Sbjct: 143 VQTLRE 148
>NP_003456
          Length = 466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVQTLRE 9
           L+QTLR+
Sbjct: 377 LIQTLRQ 383
>NP_001244930
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ +RE
Sbjct: 49 VLVQEMRE 56
>NP_970615
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLVQTLRE 9
           VLVQ +RE
Sbjct: 157 VLVQEMRE 164
>NP_001161771
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4 VQTLRE 9
         VQTLRE
Sbjct: 4 VQTLRE 9
>NP_001244932
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ +RE
Sbjct: 49 VLVQEMRE 56
>NP_068569
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VLVQTLRE 9
          VLVQ +RE
Sbjct: 49 VLVQEMRE 56
>NP_002018
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RVLVQTLRE 9
           RVLV+ LR+
Sbjct: 173 RVLVEWLRD 181
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.141    0.343 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 335,966
Number of extensions: 739
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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