Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1135
NP_671714                                                              18    1135
XP_006715890                                                           18    1135
XP_005250160                                                           18    1135
XP_005250159                                                           18    1135
NP_940953                                                              17    4312
NP_005605                                                              17    4312
XP_006716144                                                           17    4312
XP_005273179                                                           17    4312
XP_006711367                                                           17    4312
XP_005273178                                                           17    4312
XP_005244985                                                           16    5631
NP_001186456                                                           16    7355
NP_001186457                                                           16    7355
NP_001004416                                                           16    7355
NP_775839                                                              16    7355
NP_001275635                                                           15    9605
NP_060502                                                              15    9605
NP_958815                                                              15    9605
NP_000868                                                              15    9605
NP_065759                                                              15    9605
NP_001128243                                                           15    9605
NP_009106                                                              15    9605
NP_001252                                                              15    9605
NP_001964                                                              15    9605
NP_055524                                                              15    9605
NP_005018                                                              15    9605
NP_065825                                                              15    9605
XP_006720967                                                           15    9605
XP_005255486                                                           15    9605
XP_005255485                                                           15    9605
XP_005255484                                                           15    9605
XP_006720966                                                           15    9605
XP_005255483                                                           15    9605
XP_006716343                                                           15    9605
XP_005273449                                                           15    9605
XP_005273448                                                           15    9605
XP_005263991                                                           15    9605
XP_005263989                                                           15    9605
XP_005263990                                                           15    9605
XP_005263988                                                           15    9605
XP_005263987                                                           15    9605
XP_005263986                                                           15    9605
XP_005245008                                                           15    9605
XP_005245007                                                           15    9605
NP_068567                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RVLLESEKV 9
            +VLLESEKV
Sbjct: 3299 QVLLESEKV 3307
>NP_671714
          Length = 3899

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RVLLESEKV 9
            +VLLESEKV
Sbjct: 3291 QVLLESEKV 3299
>XP_006715890
          Length = 3860

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RVLLESEKV 9
            +VLLESEKV
Sbjct: 3252 QVLLESEKV 3260
>XP_005250160
          Length = 3939

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RVLLESEKV 9
            +VLLESEKV
Sbjct: 3331 QVLLESEKV 3339
>XP_005250159
          Length = 3952

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RVLLESEKV 9
            +VLLESEKV
Sbjct: 3344 QVLLESEKV 3352
>NP_940953
          Length = 1907

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RVLLESEK 8
            RV+LESE+
Sbjct: 1287 RVMLESER 1294
>NP_005605
          Length = 184

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RVLLESEKV 9
           R++LE+EK+
Sbjct: 162 RIILEAEKM 170
>XP_006716144
          Length = 173

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RVLLESEKV 9
           R++LE+EK+
Sbjct: 151 RIILEAEKM 159
>XP_005273179
          Length = 785

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RVLLESEK 8
           RV+LESE+
Sbjct: 165 RVMLESER 172
>XP_006711367
          Length = 1872

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RVLLESEK 8
            RV+LESE+
Sbjct: 1287 RVMLESER 1294
>XP_005273178
          Length = 1931

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RVLLESEK 8
            RV+LESE+
Sbjct: 1287 RVMLESER 1294
>XP_005244985
          Length = 481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VLLESEK 8
           +LLESEK
Sbjct: 438 ILLESEK 444
>NP_001186456
          Length = 1374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RVLLESEKV 9
            RVL E EKV
Sbjct: 1046 RVLCEIEKV 1054
>NP_001186457
          Length = 1246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RVLLESEKV 9
           RVL E EKV
Sbjct: 918 RVLCEIEKV 926
>NP_001004416
          Length = 1318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RVLLESEKV 9
           RVL E EKV
Sbjct: 990 RVLCEIEKV 998
>NP_775839
          Length = 1446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    RVLLESEKV 9
            RVL E EKV
Sbjct: 1118 RVLCEIEKV 1126
>NP_001275635
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE EK+
Sbjct: 455 VLLELEKI 462
>NP_060502
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           ++L+E EKV
Sbjct: 154 KILMEVEKV 162
>NP_958815
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           ++L+E EKV
Sbjct: 154 KILMEVEKV 162
>NP_000868
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE EK+
Sbjct: 486 VLLELEKI 493
>NP_065759
          Length = 1116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           R L+E+EKV
Sbjct: 730 RRLMEAEKV 738
>NP_001128243
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           R L+E+EKV
Sbjct: 753 RRLMEAEKV 761
>NP_009106
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           + L+E+EKV
Sbjct: 213 KALIEAEKV 221
>NP_001252
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  RVLLESEK 8
          +VL+E+EK
Sbjct: 49 KVLMENEK 56
>NP_001964
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE +KV
Sbjct: 306 VLLEKDKV 313
>NP_055524
          Length = 3546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RVLLESEK 8
            R+LLES++
Sbjct: 2950 RILLESDE 2957
>NP_005018
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           R+LL SE++
Sbjct: 520 RILLNSERL 528
>NP_065825
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RVLLESEK 8
           RVLLES +
Sbjct: 134 RVLLESRR 141
>XP_006720967
          Length = 272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           ++L+E EKV
Sbjct: 101 KILMEVEKV 109
>XP_005255486
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RVLLESEKV 9
          ++L+E EKV
Sbjct: 68 KILMEVEKV 76
>XP_005255485
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RVLLESEKV 9
          ++L+E EKV
Sbjct: 68 KILMEVEKV 76
>XP_005255484
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           ++L+E EKV
Sbjct: 101 KILMEVEKV 109
>XP_006720966
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           ++L+E EKV
Sbjct: 101 KILMEVEKV 109
>XP_005255483
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           ++L+E EKV
Sbjct: 154 KILMEVEKV 162
>XP_006716343
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           + L+E+EKV
Sbjct: 131 KALIEAEKV 139
>XP_005273449
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           + L+E+EKV
Sbjct: 213 KALIEAEKV 221
>XP_005273448
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RVLLESEKV 9
           + L+E+EKV
Sbjct: 325 KALIEAEKV 333
>XP_005263991
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE EK+
Sbjct: 486 VLLELEKI 493
>XP_005263989
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE EK+
Sbjct: 486 VLLELEKI 493
>XP_005263990
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE EK+
Sbjct: 486 VLLELEKI 493
>XP_005263988
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE EK+
Sbjct: 486 VLLELEKI 493
>XP_005263987
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE EK+
Sbjct: 486 VLLELEKI 493
>XP_005263986
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE EK+
Sbjct: 486 VLLELEKI 493
>XP_005245008
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE +KV
Sbjct: 306 VLLEKDKV 313
>XP_005245007
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE +KV
Sbjct: 306 VLLEKDKV 313
>NP_068567
          Length = 405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VLLESEKV 9
           VLLE +KV
Sbjct: 306 VLLEKDKV 313
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.132    0.297 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 483,914
Number of extensions: 845
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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