Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              20     299
NP_005036                                                              18    1935
NP_774959                                                              18    1935
NP_001180197                                                           17    4312
NP_036287                                                              17    4312
NP_001180198                                                           17    4312
NP_001257661                                                           17    4312
XP_006723189                                                           17    4312
XP_006723188                                                           17    4312
NP_001194005                                                           16    5631
NP_543024                                                              16    5631
XP_006723777                                                           16    5631
XP_005260352                                                           16    5631
NP_001157790                                                           16    7355
NP_001157791                                                           16    7355
NP_001157789                                                           16    7355
NP_001448                                                              16    7355
NP_001240841                                                           16    7355
NP_055988                                                              16    7355
NP_036307                                                              16    7355
NP_208385                                                              16    7355
NP_932348                                                              16    7355
NP_055905                                                              16    7355
NP_001153804                                                           16    7355
NP_001005388                                                           16    7355
NP_006397                                                              16    7355
NP_001153803                                                           16    7355
XP_005274495                                                           16    7355
XP_005256402                                                           16    7355
XP_006722342                                                           16    7355
XP_005252908                                                           16    7355
XP_006714063                                                           16    7355
XP_005262705                                                           16    7355
XP_006714062                                                           16    7355
XP_005262704                                                           16    7355
XP_005262703                                                           16    7355
XP_006713130                                                           16    7355
XP_005265039                                                           16    7355
XP_005265038                                                           16    7355
XP_005265035                                                           16    7355
XP_005265034                                                           16    7355
XP_006711299                                                           16    7355
XP_005245053                                                           16    7355
XP_006711298                                                           16    7355
XP_005245050                                                           16    7355
XP_005245049                                                           16    7355
XP_005245048                                                           16    7355
XP_005245046                                                           16    7355
XP_005245043                                                           16    7355
XP_006711297                                                           16    7355
XP_006711296                                                           16    7355
XP_006711295                                                           16    7355
XP_006711294                                                           16    7355
XP_006711293                                                           16    7355
XP_005245042                                                           16    7355
XP_006711292                                                           16    7355
XP_006711291                                                           16    7355
XP_006711290                                                           16    7355
XP_006711289                                                           16    7355
XP_005245034                                                           16    7355
NP_065095                                                              15    9605
NP_689580                                                              15    9605
NP_001244074                                                           15    9605
NP_054722                                                              15    9605
NP_085911                                                              15    9605
NP_004390                                                              15    9605
XP_005256326                                                           15    9605
XP_005253390                                                           15    9605
XP_006719114                                                           15    9605
XP_006719113                                                           15    9605
XP_005246000                                                           15    9605
XP_006710404                                                           15    9605
>NP_004351
          Length = 882

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RVEVSKDFG 9
           RVEVS+DFG
Sbjct: 492 RVEVSEDFG 500
>NP_005036
          Length = 3460

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RVEVSKDFG 9
            R+E S+DFG
Sbjct: 2040 RLEFSRDFG 2048
>NP_774959
          Length = 3458

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RVEVSKDFG 9
            R+E S+DFG
Sbjct: 2040 RLEFSRDFG 2048
>NP_001180197
          Length = 850

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VEVSKDFG 9
           VEV +DFG
Sbjct: 532 VEVPEDFG 539
>NP_036287
          Length = 649

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VEVSKDFG 9
           VEV +DFG
Sbjct: 331 VEVPEDFG 338
>NP_001180198
          Length = 796

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VEVSKDFG 9
           VEV +DFG
Sbjct: 478 VEVPEDFG 485
>NP_001257661
          Length = 128

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  EVSKDFG 9
          E+S+DFG
Sbjct: 73 EISEDFG 79
>XP_006723189
          Length = 795

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VEVSKDFG 9
           VEV +DFG
Sbjct: 477 VEVPEDFG 484
>XP_006723188
          Length = 849

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VEVSKDFG 9
           VEV +DFG
Sbjct: 531 VEVPEDFG 538
>NP_001194005
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSKDFG 9
           +SKDFG
Sbjct: 270 ISKDFG 275
>NP_543024
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSKDFG 9
           +SKDFG
Sbjct: 270 ISKDFG 275
>XP_006723777
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSKDFG 9
           +SKDFG
Sbjct: 163 ISKDFG 168
>XP_005260352
          Length = 576

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSKDFG 9
           +SKDFG
Sbjct: 270 ISKDFG 275
>NP_001157790
          Length = 2591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RVEVSKD 7
           RVEV KD
Sbjct: 955 RVEVGKD 961
>NP_001157791
          Length = 2578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RVEVSKD 7
           RVEV KD
Sbjct: 955 RVEVGKD 961
>NP_001157789
          Length = 2633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RVEVSKD 7
           RVEV KD
Sbjct: 955 RVEVGKD 961
>NP_001448
          Length = 2602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RVEVSKD 7
           RVEV KD
Sbjct: 955 RVEVGKD 961
>NP_001240841
          Length = 1159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  EVSKDFG 9
          EVS DFG
Sbjct: 16 EVSVDFG 22
>NP_055988
          Length = 1168

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  EVSKDFG 9
          EVS DFG
Sbjct: 16 EVSVDFG 22
>NP_036307
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RVEVSKD 7
           R+E+SKD
Sbjct: 311 RIEMSKD 317
>NP_208385
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RVEVSKD 7
           R+E+SKD
Sbjct: 311 RIEMSKD 317
>NP_932348
          Length = 915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EVSKDF 8
           E+SKDF
Sbjct: 511 EISKDF 516
>NP_055905
          Length = 1169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 796 RVQAENDFG 804
>NP_001153804
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 796 RVQAENDFG 804
>NP_001005388
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 800 RVQAENDFG 808
>NP_006397
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   EVSKDFG 9
           ++SKD+G
Sbjct: 183 QISKDYG 189
>NP_001153803
          Length = 1189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 811 RVQAENDFG 819
>XP_005274495
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   EVSKDFG 9
           ++SKD+G
Sbjct: 169 QISKDYG 175
>XP_005256402
          Length = 751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EVSKDF 8
           E+SKDF
Sbjct: 511 EISKDF 516
>XP_006722342
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EVSKDF 8
           E+SKDF
Sbjct: 522 EISKDF 527
>XP_005252908
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RVEVSKD 7
           R+E+SKD
Sbjct: 306 RIEMSKD 312
>XP_006714063
          Length = 1168

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  EVSKDFG 9
          EVS DFG
Sbjct: 16 EVSVDFG 22
>XP_005262705
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  EVSKDFG 9
          EVS DFG
Sbjct: 16 EVSVDFG 22
>XP_006714062
          Length = 1262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  EVSKDFG 9
          EVS DFG
Sbjct: 16 EVSVDFG 22
>XP_005262704
          Length = 1262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  EVSKDFG 9
          EVS DFG
Sbjct: 16 EVSVDFG 22
>XP_005262703
          Length = 1275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  EVSKDFG 9
          EVS DFG
Sbjct: 16 EVSVDFG 22
>XP_006713130
          Length = 2109

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RVEVSKD 7
           RVEV KD
Sbjct: 955 RVEVGKD 961
>XP_005265039
          Length = 2177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RVEVSKD 7
           RVEV KD
Sbjct: 955 RVEVGKD 961
>XP_005265038
          Length = 2181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RVEVSKD 7
           RVEV KD
Sbjct: 955 RVEVGKD 961
>XP_005265035
          Length = 2609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RVEVSKD 7
           RVEV KD
Sbjct: 955 RVEVGKD 961
>XP_005265034
          Length = 2622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RVEVSKD 7
           RVEV KD
Sbjct: 955 RVEVGKD 961
>XP_006711299
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 966 RVQAENDFG 974
>XP_005245053
          Length = 1232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 966 RVQAENDFG 974
>XP_006711298
          Length = 1299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 934 RVQAENDFG 942
>XP_005245050
          Length = 1306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 928 RVQAENDFG 936
>XP_005245049
          Length = 1318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 945 RVQAENDFG 953
>XP_005245048
          Length = 1323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 945 RVQAENDFG 953
>XP_005245046
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 960 RVQAENDFG 968
>XP_005245043
          Length = 1389

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 949 RVQAENDFG 957
>XP_006711297
          Length = 1391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 934 RVQAENDFG 942
>XP_006711296
          Length = 1391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 844 RVQAENDFG 852
>XP_006711295
          Length = 1400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 853 RVQAENDFG 861
>XP_006711294
          Length = 1400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 960 RVQAENDFG 968
>XP_006711293
          Length = 1402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 934 RVQAENDFG 942
>XP_005245042
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 966 RVQAENDFG 974
>XP_006711292
          Length = 1428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 881 RVQAENDFG 889
>XP_006711291
          Length = 1430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 934 RVQAENDFG 942
>XP_006711290
          Length = 1434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 887 RVQAENDFG 895
>XP_006711289
          Length = 1475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 928 RVQAENDFG 936
>XP_005245034
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RV+   DFG
Sbjct: 934 RVQAENDFG 942
>NP_065095
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VEVSKDFG 9
           + +SK+FG
Sbjct: 154 IHISKNFG 161
>NP_689580
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RVE  K FG
Sbjct: 215 RVECIKSFG 223
>NP_001244074
          Length = 880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RVEV   FG
Sbjct: 855 RVEVKATFG 863
>NP_054722
          Length = 1227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RVEVSKDF 8
           R+EV +DF
Sbjct: 390 RLEVDEDF 397
>NP_085911
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RVEV   FG
Sbjct: 881 RVEVKATFG 889
>NP_004390
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RVEV   FG
Sbjct: 831 RVEVKATFG 839
>XP_005256326
          Length = 1192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RVEVSKDF 8
           R+EV +DF
Sbjct: 355 RLEVDEDF 362
>XP_005253390
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RVEV   FG
Sbjct: 917 RVEVKATFG 925
>XP_006719114
          Length = 954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RVEV   FG
Sbjct: 904 RVEVKATFG 912
>XP_006719113
          Length = 967

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RVEV   FG
Sbjct: 917 RVEVKATFG 925
>XP_005246000
          Length = 189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VEVSKDFG 9
           + +SK+FG
Sbjct: 154 IHISKNFG 161
>XP_006710404
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RVEVSKDFG 9
           RVE  K FG
Sbjct: 96  RVECIKSFG 104
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.140    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 507,420
Number of extensions: 810
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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