Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1935
NP_001075109                                                           18    1935
NP_065087                                                              18    1935
NP_004892                                                              18    1935
NP_001122402                                                           18    1935
NP_004704                                                              17    3301
XP_005268256                                                           17    3301
NP_001032249                                                           16    5631
NP_001269657                                                           16    5631
NP_689495                                                              16    5631
NP_001242940                                                           16    5631
NP_056178                                                              16    5631
NP_001139799                                                           16    5631
NP_001139798                                                           16    5631
NP_001242939                                                           16    5631
NP_056538                                                              16    5631
NP_001242938                                                           16    5631
NP_001242937                                                           16    5631
NP_001242936                                                           16    5631
XP_005250453                                                           16    5631
XP_005247960                                                           16    5631
NP_937983                                                              16    7355
NP_005915                                                              16    7355
NP_078925                                                              16    7355
NP_001180305                                                           16    7355
NP_001243297                                                           16    7355
NP_001018081                                                           16    7355
NP_005867                                                              16    7355
NP_001035091                                                           16    7355
NP_004518                                                              16    7355
NP_077024                                                              16    7355
NP_001004432                                                           16    7355
XP_006712256                                                           16    7355
XP_005246298                                                           16    7355
XP_005246297                                                           16    7355
XP_005246299                                                           16    7355
XP_005246296                                                           16    7355
XP_006712254                                                           16    7355
XP_005246295                                                           16    7355
XP_006712253                                                           16    7355
XP_006712252                                                           16    7355
XP_005246294                                                           16    7355
XP_006712251                                                           16    7355
XP_005246293                                                           16    7355
XP_005246292                                                           16    7355
XP_006712250                                                           16    7355
NP_001274685                                                           15    9605
NP_001274679                                                           15    9605
NP_001274678                                                           15    9605
NP_001274680                                                           15    9605
NP_001274672                                                           15    9605
NP_001274673                                                           15    9605
NP_001274674                                                           15    9605
NP_004453                                                              15    9605
NP_001274677                                                           15    9605
NP_001274671                                                           15    9605
NP_001274676                                                           15    9605
NP_001254743                                                           15    9605
NP_001254741                                                           15    9605
NP_064631                                                              15    9605
NP_443100                                                              15    9605
NP_001193594                                                           15    9605
XP_005252332                                                           15    9605
XP_005252333                                                           15    9605
XP_005250561                                                           15    9605
XP_006716122                                                           15    9605
XP_005250560                                                           15    9605
XP_006716121                                                           15    9605
XP_006716120                                                           15    9605
XP_006716119                                                           15    9605
XP_006716118                                                           15    9605
XP_006716117                                                           15    9605
XP_005250559                                                           15    9605
XP_006711694                                                           15    9605
XP_005245671                                                           15    9605
NP_115718                                                              15    9605
>NP_008835
          Length = 4128

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RTYLLRLRR 9
            RT LLRLRR
Sbjct: 2722 RTDLLRLRR 2730
>NP_001075109
          Length = 4097

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RTYLLRLRR 9
            RT LLRLRR
Sbjct: 2722 RTDLLRLRR 2730
>NP_065087
          Length = 604

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           YLLRLRR
Sbjct: 568 YLLRLRR 574
>NP_004892
          Length = 616

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           YLLRLRR
Sbjct: 581 YLLRLRR 587
>NP_001122402
          Length = 608

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           YLLRLRR
Sbjct: 573 YLLRLRR 579
>NP_004704
          Length = 1076

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  RTYLLRLRR 9
          +TYL+RL++
Sbjct: 35 KTYLIRLQK 43
>XP_005268256
          Length = 1055

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  RTYLLRLRR 9
          +TYL+RL++
Sbjct: 35 KTYLIRLQK 43
>NP_001032249
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTYLLRLR 8
           R YLLRL+
Sbjct: 260 RQYLLRLK 267
>NP_001269657
          Length = 442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTYLLRLR 8
           R YLLRL+
Sbjct: 222 RQYLLRLK 229
>NP_689495
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTYLLRLR 8
           R YLLRL+
Sbjct: 260 RQYLLRLK 267
>NP_001242940
          Length = 682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           YLLRLR+
Sbjct: 308 YLLRLRQ 314
>NP_056178
          Length = 527

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RTYLLRLRR 9
           +TYL+R +R
Sbjct: 448 KTYLIRYQR 456
>NP_001139799
          Length = 527

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RTYLLRLRR 9
           +TYL+R +R
Sbjct: 448 KTYLIRYQR 456
>NP_001139798
          Length = 527

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RTYLLRLRR 9
           +TYL+R +R
Sbjct: 448 KTYLIRYQR 456
>NP_001242939
          Length = 682

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           YLLRLR+
Sbjct: 308 YLLRLRQ 314
>NP_056538
          Length = 782

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           YLLRLR+
Sbjct: 408 YLLRLRQ 414
>NP_001242938
          Length = 720

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           YLLRLR+
Sbjct: 408 YLLRLRQ 414
>NP_001242937
          Length = 782

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           YLLRLR+
Sbjct: 408 YLLRLRQ 414
>NP_001242936
          Length = 782

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           YLLRLR+
Sbjct: 408 YLLRLRQ 414
>XP_005250453
          Length = 720

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           YLLRLR+
Sbjct: 408 YLLRLRQ 414
>XP_005247960
          Length = 463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTYLLRLR 8
           R YLLRL+
Sbjct: 243 RQYLLRLK 250
>NP_937983
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RTYLLRLR 8
           RT++LR+R
Sbjct: 691 RTFVLRVR 698
>NP_005915
          Length = 304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YLLRLRR 9
           YL RLRR
Sbjct: 211 YLTRLRR 217
>NP_078925
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   YLLRLR 8
           YLLRLR
Sbjct: 457 YLLRLR 462
>NP_001180305
          Length = 1069

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RTYLLRLR 8
           RT++LR+R
Sbjct: 691 RTFVLRVR 698
>NP_001243297
          Length = 102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2 TYLLRLR 8
         TY+L+LR
Sbjct: 3 TYILKLR 9
>NP_001018081
          Length = 1309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RTYLLRLR 8
           R+YLLR R
Sbjct: 205 RSYLLRKR 212
>NP_005867
          Length = 3267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 3222 YLMKLRR 3228
>NP_001035091
          Length = 139

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  YLLRLRR 9
          YL RLRR
Sbjct: 80 YLTRLRR 86
>NP_004518
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YLLRLRR 9
           YL RLRR
Sbjct: 195 YLTRLRR 201
>NP_077024
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RTYLLRLRR 9
           R Y L LRR
Sbjct: 278 RVYALHLRR 286
>NP_001004432
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YLLRLRR 9
           +LLRLRR
Sbjct: 368 WLLRLRR 374
>XP_006712256
          Length = 2418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 2373 YLMKLRR 2379
>XP_005246298
          Length = 2418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 2373 YLMKLRR 2379
>XP_005246297
          Length = 2418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 2373 YLMKLRR 2379
>XP_005246299
          Length = 2480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 2435 YLMKLRR 2441
>XP_005246296
          Length = 2475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 2430 YLMKLRR 2436
>XP_006712254
          Length = 2475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 2430 YLMKLRR 2436
>XP_005246295
          Length = 3114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 3069 YLMKLRR 3075
>XP_006712253
          Length = 3117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 3072 YLMKLRR 3078
>XP_006712252
          Length = 3163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 3118 YLMKLRR 3124
>XP_005246294
          Length = 3173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 3128 YLMKLRR 3134
>XP_006712251
          Length = 3176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 3131 YLMKLRR 3137
>XP_005246293
          Length = 3206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 3161 YLMKLRR 3167
>XP_005246292
          Length = 3208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 3163 YLMKLRR 3169
>XP_006712250
          Length = 3248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    YLLRLRR 9
            YL++LRR
Sbjct: 3203 YLMKLRR 3209
>NP_001274685
          Length = 250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 108 TYLSRLR 114
>NP_001274679
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 334 TYLSRLR 340
>NP_001274678
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 211 TYLSRLR 217
>NP_001274680
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 190 TYLSRLR 196
>NP_001274672
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 275 TYLSRLR 281
>NP_001274673
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 211 TYLSRLR 217
>NP_001274674
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 211 TYLSRLR 217
>NP_004453
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 275 TYLSRLR 281
>NP_001274677
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 211 TYLSRLR 217
>NP_001274671
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 275 TYLSRLR 281
>NP_001274676
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TYLLRLR 8
           TYL RLR
Sbjct: 211 TYLSRLR 217
>NP_001254743
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 425 RKYLLRL 431
>NP_001254741
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 514 RKYLLRL 520
>NP_064631
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 514 RKYLLRL 520
>NP_443100
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           RTY LRL
Sbjct: 387 RTYRLRL 393
>NP_001193594
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           RTY LRL
Sbjct: 387 RTYRLRL 393
>XP_005252332
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RTYLLRLRR 9
           R Y L LRR
Sbjct: 310 RHYFLELRR 318
>XP_005252333
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RTYLLRLRR 9
           R Y L LRR
Sbjct: 310 RHYFLELRR 318
>XP_005250561
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 156 RKYLLRL 162
>XP_006716122
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 250 RKYLLRL 256
>XP_005250560
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 250 RKYLLRL 256
>XP_006716121
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 250 RKYLLRL 256
>XP_006716120
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 250 RKYLLRL 256
>XP_006716119
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 250 RKYLLRL 256
>XP_006716118
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 411 RKYLLRL 417
>XP_006716117
          Length = 825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 425 RKYLLRL 431
>XP_005250559
          Length = 825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           R YLLRL
Sbjct: 425 RKYLLRL 431
>XP_006711694
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           RTY LRL
Sbjct: 370 RTYRLRL 376
>XP_005245671
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RTYLLRL 7
           RTY LRL
Sbjct: 387 RTYRLRL 393
>NP_115718
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RTYLLRLRR 9
           R Y L LRR
Sbjct: 310 RHYFLELRR 318
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.352    0.159    0.455 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 500,231
Number of extensions: 895
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.9 bits)
S2: 28 (15.4 bits)

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