Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              20     509
XP_006717989                                                           20     509
NP_777560                                                              17    2528
NP_002086                                                              17    4312
NP_001116295                                                           17    4312
XP_005272291                                                           17    4312
NP_036219                                                              17    4312
NP_001273653                                                           16    5631
NP_714928                                                              16    5631
NP_001271354                                                           16    5631
NP_001271353                                                           16    5631
NP_001271352                                                           16    5631
NP_056275                                                              16    5631
NP_001273651                                                           16    5631
NP_055427                                                              16    5631
NP_001273652                                                           16    5631
NP_001271355                                                           16    5631
XP_005251899                                                           16    5631
XP_005248009                                                           16    5631
XP_006713930                                                           16    5631
XP_006713929                                                           16    5631
XP_006713928                                                           16    5631
XP_006713162                                                           16    5631
NP_001029031                                                           16    7355
NP_001257377                                                           16    7355
NP_000009                                                              16    7355
NP_037453                                                              16    7355
NP_079170                                                              16    7355
NP_114432                                                              16    7355
NP_001165349                                                           16    7355
NP_001248323                                                           16    7355
NP_001271347                                                           16    7355
NP_001271346                                                           16    7355
NP_001248321                                                           16    7355
NP_001257376                                                           16    7355
NP_001165350                                                           16    7355
NP_005360                                                              16    7355
NP_001165347                                                           16    7355
NP_612152                                                              16    7355
XP_006724820                                                           16    7355
XP_005262471                                                           16    7355
XP_005262470                                                           16    7355
XP_006721579                                                           16    7355
XP_005255571                                                           16    7355
XP_006720997                                                           16    7355
XP_006720459                                                           16    7355
XP_006715715                                                           16    7355
NP_001165348                                                           16    7355
NP_001093325                                                           16    7355
NP_001258218                                                           15    9605
NP_001258217                                                           15    9605
NP_000134                                                              15    9605
NP_001258216                                                           15    9605
NP_005849                                                              15    9605
NP_006436                                                              15    9605
NP_001258247                                                           15    9605
NP_115810                                                              15    9605
NP_001258215                                                           15    9605
NP_060695                                                              15    9605
NP_060597                                                              15    9605
NP_001159434                                                           15    9605
NP_776065                                                              15    9605
NP_001136018                                                           15    9605
NP_036586                                                              15    9605
NP_005040                                                              15    9605
NP_361013                                                              15    9605
NP_872312                                                              15    9605
XP_006723973                                                           15    9605
XP_005259763                                                           15    9605
XP_005251560                                                           15    9605
XP_006710159                                                           15    9605
NP_705834                                                              15    9605
>NP_000305
          Length = 403

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RTRHKKGVT 9
           RTR KKGVT
Sbjct: 159 RTRDKKGVT 167
>XP_006717989
          Length = 388

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RTRHKKGVT 9
           RTR KKGVT
Sbjct: 144 RTRDKKGVT 152
>NP_777560
          Length = 310

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  RTRHKKGV 8
          +TRH+KG+
Sbjct: 10 KTRHQKGL 17
>NP_002086
          Length = 291

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RTRHKKGVT 9
          +TRH++G T
Sbjct: 86 KTRHQRGDT 94
>NP_001116295
          Length = 526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RTRHKKGV 8
          RTR +KGV
Sbjct: 91 RTRRQKGV 98
>XP_005272291
          Length = 537

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RTRHKKGV 8
          RTR +KGV
Sbjct: 91 RTRRQKGV 98
>NP_036219
          Length = 519

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RTRHKKGV 8
          RTR +KGV
Sbjct: 91 RTRRQKGV 98
>NP_001273653
          Length = 628

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           RHKKG+
Sbjct: 562 RHKKGL 567
>NP_714928
          Length = 992

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RTRHKKGVT 9
          RTRH+K  T
Sbjct: 54 RTRHQKDDT 62
>NP_001271354
          Length = 770

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RTRHKKGVT 9
           RT+ +KG T
Sbjct: 748 RTKERKGTT 756
>NP_001271353
          Length = 794

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RTRHKKGVT 9
           RT+ +KG T
Sbjct: 772 RTKERKGTT 780
>NP_001271352
          Length = 859

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RTRHKKGVT 9
           RT+ +KG T
Sbjct: 837 RTKERKGTT 845
>NP_056275
          Length = 859

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RTRHKKGVT 9
           RT+ +KG T
Sbjct: 837 RTKERKGTT 845
>NP_001273651
          Length = 1117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           RHKKG+
Sbjct: 561 RHKKGL 566
>NP_055427
          Length = 1118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           RHKKG+
Sbjct: 562 RHKKGL 567
>NP_001273652
          Length = 651

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           RHKKG+
Sbjct: 562 RHKKGL 567
>NP_001271355
          Length = 672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RTRHKKGVT 9
           RT+ +KG T
Sbjct: 650 RTKERKGTT 658
>XP_005251899
          Length = 1117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           RHKKG+
Sbjct: 562 RHKKGL 567
>XP_005248009
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RTRHKKGVT 9
          RTRH+K  T
Sbjct: 54 RTRHQKDDT 62
>XP_006713930
          Length = 772

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RTRHKKGVT 9
          RTRH+K  T
Sbjct: 54 RTRHQKDDT 62
>XP_006713929
          Length = 930

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RTRHKKGVT 9
          RTRH+K  T
Sbjct: 54 RTRHQKDDT 62
>XP_006713928
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RTRHKKGVT 9
          RTRH+K  T
Sbjct: 54 RTRHQKDDT 62
>XP_006713162
          Length = 868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RTRHKKGVT 9
           RT+ +KG T
Sbjct: 837 RTKERKGTT 845
>NP_001029031
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           +HKKG+
Sbjct: 531 KHKKGI 536
>NP_001257377
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           +HKKG+
Sbjct: 477 KHKKGI 482
>NP_000009
          Length = 655

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           +HKKG+
Sbjct: 553 KHKKGI 558
>NP_037453
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           RH+KGV
Sbjct: 333 RHEKGV 338
>NP_079170
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTRHKKG 7
           ++RHK+G
Sbjct: 678 KSRHKRG 684
>NP_114432
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TRHKKGVT 9
           T HK G+T
Sbjct: 476 TLHKMGIT 483
>NP_001165349
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           HKKG T
Sbjct: 706 HKKGAT 711
>NP_001248323
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTRHKKG 7
           ++RHK+G
Sbjct: 628 KSRHKRG 634
>NP_001271347
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  RTRHKKGV 8
          + RHK GV
Sbjct: 53 KERHKSGV 60
>NP_001271346
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  RTRHKKGV 8
          + RHK GV
Sbjct: 53 KERHKSGV 60
>NP_001248321
          Length = 662

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTRHKKG 7
           ++RHK+G
Sbjct: 652 KSRHKRG 658
>NP_001257376
          Length = 678

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           +HKKG+
Sbjct: 576 KHKKGI 581
>NP_001165350
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           HKKG T
Sbjct: 722 HKKGAT 727
>NP_005360
          Length = 925

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           HKKG T
Sbjct: 706 HKKGAT 711
>NP_001165347
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           HKKG T
Sbjct: 782 HKKGAT 787
>NP_612152
          Length = 2849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    RHKKGVT 9
            RH++G+T
Sbjct: 1441 RHEEGIT 1447
>XP_006724820
          Length = 902

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           HKKG T
Sbjct: 683 HKKGAT 688
>XP_005262471
          Length = 1005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           HKKG T
Sbjct: 851 HKKGAT 856
>XP_005262470
          Length = 1044

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           HKKG T
Sbjct: 825 HKKGAT 830
>XP_006721579
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RHKKGV 8
           +HKKG+
Sbjct: 599 KHKKGI 604
>XP_005255571
          Length = 1112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  RTRHKKGV 8
          +TRH++G+
Sbjct: 5  QTRHREGL 12
>XP_006720997
          Length = 1124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  RTRHKKGV 8
          +TRH++G+
Sbjct: 17 QTRHREGL 24
>XP_006720459
          Length = 296

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  RTRHKKGV 8
          + RHK GV
Sbjct: 53 KERHKSGV 60
>XP_006715715
          Length = 2023

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    RHKKGVT 9
            RH++G+T
Sbjct: 1393 RHEEGIT 1399
>NP_001165348
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           HKKG T
Sbjct: 667 HKKGAT 672
>NP_001093325
          Length = 985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           HKKG T
Sbjct: 766 HKKGAT 771
>NP_001258218
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   RTRHKKG 7
           +T HK+G
Sbjct: 454 KTNHKRG 460
>NP_001258217
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   RTRHKKG 7
           +T HK+G
Sbjct: 482 KTNHKRG 488
>NP_000134
          Length = 510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RTRHKKGVT 9
           +T HK G T
Sbjct: 473 KTAHKNGST 481
>NP_001258216
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   RTRHKKG 7
           +T HK+G
Sbjct: 482 KTNHKRG 488
>NP_005849
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TRHKKGV 8
           T H+KGV
Sbjct: 633 TAHEKGV 639
>NP_006436
          Length = 2335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   RHKKGV 8
           RH KGV
Sbjct: 663 RHSKGV 668
>NP_001258247
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   RTRHKKG 7
           +T HK+G
Sbjct: 482 KTNHKRG 488
>NP_115810
          Length = 567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   RTRHKKG 7
           +T HK+G
Sbjct: 559 KTNHKRG 565
>NP_001258215
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   RTRHKKG 7
           +T HK+G
Sbjct: 530 KTNHKRG 536
>NP_060695
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           H KGVT
Sbjct: 306 HSKGVT 311
>NP_060597
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  RTRHKKG 7
          RTR K+G
Sbjct: 41 RTREKRG 47
>NP_001159434
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  RTRHKKG 7
          RTR K+G
Sbjct: 41 RTREKRG 47
>NP_776065
          Length = 825

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  RTRHKKG 7
          RTR K+G
Sbjct: 41 RTREKRG 47
>NP_001136018
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TRHKKGV 8
           T HK+GV
Sbjct: 621 TSHKEGV 627
>NP_036586
          Length = 1701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RTRHKKGV 8
           R R+KKG+
Sbjct: 757 RGRNKKGI 764
>NP_005040
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TRHKKGVT 9
           T H  GVT
Sbjct: 412 TEHSSGVT 419
>NP_361013
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TRHKKGV 8
           T HK+GV
Sbjct: 621 TSHKEGV 627
>NP_872312
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  TRHKKGV 8
          TRH +GV
Sbjct: 80 TRHPEGV 86
>XP_006723973
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TRHKKGVT 9
           T H  GVT
Sbjct: 412 TEHSSGVT 419
>XP_005259763
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TRHKKGV 8
           T H+KGV
Sbjct: 620 TAHEKGV 626
>XP_005251560
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   HKKGVT 9
           H KGVT
Sbjct: 255 HSKGVT 260
>XP_006710159
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TRHKKGVT 9
           T H  GVT
Sbjct: 412 TEHSSGVT 419
>NP_705834
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   RTRHKKG 7
           RT HK G
Sbjct: 503 RTSHKSG 509
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.128    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 711,529
Number of extensions: 1083
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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