Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              21     229
NP_671714                                                              21     229
XP_006715890                                                           21     229
XP_005250160                                                           21     229
XP_005250159                                                           21     229
NP_001278327                                                           17    2528
NP_001005751                                                           17    2528
NP_001162578                                                           17    2528
XP_005269867                                                           17    2528
XP_006717895                                                           17    2528
XP_005269865                                                           17    2528
XP_006717894                                                           17    2528
XP_005269864                                                           17    2528
XP_005269863                                                           17    2528
NP_001162577                                                           17    2528
NP_056077                                                              17    2528
NP_659415                                                              17    4312
XP_005263951                                                           17    4312
XP_006712408                                                           17    4312
XP_006712407                                                           17    4312
NP_000341                                                              16    5631
NP_078958                                                              16    5631
NP_001161694                                                           16    5631
NP_005722                                                              16    5631
NP_690601                                                              16    5631
XP_006723448                                                           16    5631
XP_006712236                                                           16    5631
NP_001315                                                              16    5631
NP_001028693                                                           16    5631
NP_001028694                                                           16    5631
NP_001001674                                                           16    5631
NP_001264090                                                           16    7355
NP_004736                                                              16    7355
XP_005266095                                                           16    7355
NP_940980                                                              15    9605
NP_008835                                                              15    9605
NP_001075109                                                           15    9605
NP_689520                                                              15    9605
NP_997191                                                              15    9605
NP_001152956                                                           15    9605
NP_006159                                                              15    9605
NP_001257609                                                           15    9605
NP_001257608                                                           15    9605
NP_612366                                                              15    9605
XP_005268686                                                           15    9605
XP_006714293                                                           15    9605
XP_006711682                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RTQLLFSHK 9
           RTQLLFSH+
Sbjct: 626 RTQLLFSHE 634
>NP_671714
          Length = 3899

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RTQLLFSHK 9
           RTQLLFSH+
Sbjct: 626 RTQLLFSHE 634
>XP_006715890
          Length = 3860

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RTQLLFSHK 9
           RTQLLFSH+
Sbjct: 626 RTQLLFSHE 634
>XP_005250160
          Length = 3939

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RTQLLFSHK 9
           RTQLLFSH+
Sbjct: 626 RTQLLFSHE 634
>XP_005250159
          Length = 3952

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RTQLLFSHK 9
           RTQLLFSH+
Sbjct: 626 RTQLLFSHE 634
>NP_001278327
          Length = 1320

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 844 ELLFSHK 850
>NP_001005751
          Length = 1341

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 844 ELLFSHK 850
>NP_001162578
          Length = 1245

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 769 ELLFSHK 775
>XP_005269867
          Length = 742

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 245 ELLFSHK 251
>XP_006717895
          Length = 1297

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 821 ELLFSHK 827
>XP_005269865
          Length = 1331

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 896 ELLFSHK 902
>XP_006717894
          Length = 1342

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 845 ELLFSHK 851
>XP_005269864
          Length = 1364

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 867 ELLFSHK 873
>XP_005269863
          Length = 1369

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 872 ELLFSHK 878
>NP_001162577
          Length = 1279

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 844 ELLFSHK 850
>NP_056077
          Length = 1320

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           +LLFSHK
Sbjct: 844 ELLFSHK 850
>NP_659415
          Length = 665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RTQLLFSHK 9
           R QLLF H+
Sbjct: 215 REQLLFRHE 223
>XP_005263951
          Length = 577

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RTQLLFSHK 9
           R QLLF H+
Sbjct: 215 REQLLFRHE 223
>XP_006712408
          Length = 583

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RTQLLFSHK 9
           R QLLF H+
Sbjct: 221 REQLLFRHE 229
>XP_006712407
          Length = 671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RTQLLFSHK 9
           R QLLF H+
Sbjct: 221 REQLLFRHE 229
>NP_000341
          Length = 2273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    QLLFSHK 9
            QLL SHK
Sbjct: 2220 QLLLSHK 2226
>NP_078958
          Length = 648

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TQLLFSHK 9
          TQ+LFS K
Sbjct: 58 TQILFSKK 65
>NP_001161694
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TQLLFSHK 9
          TQ+LFS K
Sbjct: 25 TQILFSKK 32
>NP_005722
          Length = 300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           Q+LFSH+
Sbjct: 197 QVLFSHR 203
>NP_690601
          Length = 300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           Q+LFSH+
Sbjct: 197 QVLFSHR 203
>XP_006723448
          Length = 565

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  TQLLFSHK 9
          TQ+LFS K
Sbjct: 58 TQILFSKK 65
>XP_006712236
          Length = 245

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QLLFSHK 9
           Q+LFSH+
Sbjct: 142 QVLFSHR 148
>NP_001315
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RTQLLFSH 8
           RTQ +F+H
Sbjct: 356 RTQAVFNH 363
>NP_001028693
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RTQLLFSH 8
           RTQ +F+H
Sbjct: 356 RTQAVFNH 363
>NP_001028694
          Length = 431

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RTQLLFSH 8
           RTQ +F+H
Sbjct: 356 RTQAVFNH 363
>NP_001001674
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TQLLFSH 8
           TQ+ FSH
Sbjct: 99  TQIFFSH 105
>NP_001264090
          Length = 961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTQLLFSHK 9
           RTQ LFS++
Sbjct: 728 RTQGLFSYR 736
>NP_004736
          Length = 975

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTQLLFSHK 9
           RTQ LFS++
Sbjct: 742 RTQGLFSYR 750
>XP_005266095
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTQLLFSHK 9
           RTQ LFS++
Sbjct: 845 RTQGLFSYR 853
>NP_940980
          Length = 2527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    QLLFSH 8
            +LLFSH
Sbjct: 1224 ELLFSH 1229
>NP_008835
          Length = 4128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LLFSHK 9
            LLF+HK
Sbjct: 2678 LLFAHK 2683
>NP_001075109
          Length = 4097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    LLFSHK 9
            LLF+HK
Sbjct: 2678 LLFAHK 2683
>NP_689520
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RTQLLFS 7
          RTQ+L+S
Sbjct: 83 RTQILYS 89
>NP_997191
          Length = 1888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RTQLLFSHK 9
           +T L+F HK
Sbjct: 328 QTNLVFVHK 336
>NP_001152956
          Length = 1736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RTQLLFSHK 9
           +T L+F HK
Sbjct: 328 QTNLVFVHK 336
>NP_006159
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TQLLFSHK 9
           TQLL  HK
Sbjct: 340 TQLLKKHK 347
>NP_001257609
          Length = 302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RTQLLFSHK 9
           R  LLF HK
Sbjct: 248 RQYLLFFHK 256
>NP_001257608
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RTQLLFSHK 9
           R  LLF HK
Sbjct: 276 RQYLLFFHK 284
>NP_612366
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RTQLLFSHK 9
           R  LLF HK
Sbjct: 297 RQYLLFFHK 305
>XP_005268686
          Length = 2521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    QLLFSH 8
            +LLFSH
Sbjct: 1224 ELLFSH 1229
>XP_006714293
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   TQLLFSHK 9
           TQLL  HK
Sbjct: 340 TQLLKKHK 347
>XP_006711682
          Length = 1739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RTQLLFSHK 9
           +T L+F HK
Sbjct: 179 QTNLVFVHK 187
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.135    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 496,276
Number of extensions: 935
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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