Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              18    1135
NP_006763                                                              17    3301
NP_008958                                                              17    4312
NP_001036249                                                           17    4312
NP_001166094                                                           17    4312
NP_002490                                                              17    4312
XP_005254473                                                           17    4312
XP_005254472                                                           17    4312
XP_005254471                                                           17    4312
XP_005254470                                                           17    4312
XP_005254469                                                           17    4312
XP_005254468                                                           17    4312
XP_005254467                                                           17    4312
XP_005254465                                                           17    4312
XP_006714268                                                           17    4312
XP_005263031                                                           17    4312
XP_006714267                                                           17    4312
XP_006714266                                                           17    4312
XP_006714265                                                           17    4312
XP_006714264                                                           17    4312
XP_006714263                                                           17    4312
XP_006714262                                                           17    4312
NP_001166095                                                           17    4312
NP_079255                                                              16    7355
NP_149035                                                              16    7355
NP_001015056                                                           16    7355
NP_001015055                                                           16    7355
NP_001106203                                                           16    7355
XP_005268373                                                           16    7355
XP_005268372                                                           16    7355
XP_005268371                                                           16    7355
XP_006720031                                                           16    7355
XP_005268370                                                           16    7355
XP_006720030                                                           16    7355
XP_005268369                                                           16    7355
XP_006720029                                                           16    7355
XP_005268367                                                           16    7355
XP_005268366                                                           16    7355
XP_005268365                                                           16    7355
XP_005268364                                                           16    7355
XP_005264536                                                           16    7355
XP_005264535                                                           16    7355
NP_001243779                                                           15    9605
NP_596869                                                              15    9605
NP_694996                                                              15    9605
NP_653184                                                              15    9605
NP_001034451                                                           15    9605
NP_001265227                                                           15    9605
XP_006712787                                                           15    9605
XP_006712786                                                           15    9605
NP_001254479                                                           15    9605
>NP_005179
          Length = 906

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSDIS A
Sbjct: 788 RTLSDISNA 796
>NP_006763
          Length = 1343

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           R L+DISTA
Sbjct: 716 RLLNDISTA 724
>NP_008958
          Length = 1522

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSD+S
Sbjct: 309 RTLSDVS 315
>NP_001036249
          Length = 1113

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RTLSDISTA 9
           RT+SD++T+
Sbjct: 496 RTISDLTTS 504
>NP_001166094
          Length = 1408

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 627 RTLSDVPSA 635
>NP_002490
          Length = 1461

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 627 RTLSDVPSA 635
>XP_005254473
          Length = 1408

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 627 RTLSDVPSA 635
>XP_005254472
          Length = 1428

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 647 RTLSDVPSA 655
>XP_005254471
          Length = 1450

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 627 RTLSDVPSA 635
>XP_005254470
          Length = 1454

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 647 RTLSDVPSA 655
>XP_005254469
          Length = 1461

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 627 RTLSDVPSA 635
>XP_005254468
          Length = 1465

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 647 RTLSDVPSA 655
>XP_005254467
          Length = 1470

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 647 RTLSDVPSA 655
>XP_005254465
          Length = 1481

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 647 RTLSDVPSA 655
>XP_006714268
          Length = 1078

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RTLSDISTA 9
           RT+SD++T+
Sbjct: 496 RTISDLTTS 504
>XP_005263031
          Length = 1113

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RTLSDISTA 9
           RT+SD++T+
Sbjct: 496 RTISDLTTS 504
>XP_006714267
          Length = 1117

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RTLSDISTA 9
           RT+SD++T+
Sbjct: 496 RTISDLTTS 504
>XP_006714266
          Length = 1125

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RTLSDISTA 9
           RT+SD++T+
Sbjct: 496 RTISDLTTS 504
>XP_006714265
          Length = 1129

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RTLSDISTA 9
           RT+SD++T+
Sbjct: 496 RTISDLTTS 504
>XP_006714264
          Length = 1129

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RTLSDISTA 9
           RT+SD++T+
Sbjct: 496 RTISDLTTS 504
>XP_006714263
          Length = 1129

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RTLSDISTA 9
           RT+SD++T+
Sbjct: 496 RTISDLTTS 504
>XP_006714262
          Length = 1129

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RTLSDISTA 9
           RT+SD++T+
Sbjct: 496 RTISDLTTS 504
>NP_001166095
          Length = 1450

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RTLSDISTA 9
           RTLSD+ +A
Sbjct: 627 RTLSDVPSA 635
>NP_079255
          Length = 1123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 142 RTLSDIA 148
>NP_149035
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTL+DIS
Sbjct: 156 RTLTDIS 162
>NP_001015056
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTL+DIS
Sbjct: 119 RTLTDIS 125
>NP_001015055
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTL+DIS
Sbjct: 169 RTLTDIS 175
>NP_001106203
          Length = 1125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 144 RTLSDIA 150
>XP_005268373
          Length = 984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 142 RTLSDIA 148
>XP_005268372
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 201 RTLSDIA 207
>XP_005268371
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 148 RTLSDIA 154
>XP_006720031
          Length = 1080

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RTLSDIS 7
          RTLSDI+
Sbjct: 74 RTLSDIA 80
>XP_005268370
          Length = 1112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 106 RTLSDIA 112
>XP_006720030
          Length = 1128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 122 RTLSDIA 128
>XP_005268369
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 126 RTLSDIA 132
>XP_006720029
          Length = 1150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 144 RTLSDIA 150
>XP_005268367
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 148 RTLSDIA 154
>XP_005268366
          Length = 1180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 174 RTLSDIA 180
>XP_005268365
          Length = 1182

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 201 RTLSDIA 207
>XP_005268364
          Length = 1207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTLSDI+
Sbjct: 201 RTLSDIA 207
>XP_005264536
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTL+DIS
Sbjct: 169 RTLTDIS 175
>XP_005264535
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RTLSDIS 7
           RTL+DIS
Sbjct: 169 RTLTDIS 175
>NP_001243779
          Length = 34350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RTLSDIST 8
            + LSDIST
Sbjct: 8423 KKLSDIST 8430
>NP_596869
          Length = 33423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RTLSDIST 8
            + LSDIST
Sbjct: 7496 KKLSDIST 7503
>NP_694996
          Length = 2526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RTLSDIST 8
           RT+ D+ST
Sbjct: 190 RTIRDLST 197
>NP_653184
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RTLSDI 6
           RTLSDI
Sbjct: 163 RTLSDI 168
>NP_001034451
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RTLSDI 6
           RTLSDI
Sbjct: 163 RTLSDI 168
>NP_001265227
          Length = 2614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RTLSDIST 8
           RT+ D+ST
Sbjct: 190 RTIRDLST 197
>XP_006712787
          Length = 33978

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RTLSDIST 8
            + LSDIST
Sbjct: 8424 KKLSDIST 8431
>XP_006712786
          Length = 35484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RTLSDIST 8
            + LSDIST
Sbjct: 8424 KKLSDIST 8431
>NP_001254479
          Length = 35991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RTLSDIST 8
            + LSDIST
Sbjct: 8740 KKLSDIST 8747
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.115    0.271 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 333,436
Number of extensions: 396
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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