Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              19     665
XP_006717990                                                           19     665
XP_006717989                                                           19     665
NP_001269607                                                           16    5631
NP_001269606                                                           16    5631
NP_000457                                                              16    5631
NP_000444                                                              16    5631
NP_666018                                                              16    5631
NP_078863                                                              16    5631
NP_848593                                                              16    5631
XP_006718220                                                           16    5631
XP_006718219                                                           16    5631
XP_006718218                                                           16    5631
XP_005250490                                                           16    5631
XP_005250486                                                           16    5631
XP_005271253                                                           16    5631
XP_005271252                                                           16    5631
XP_005271251                                                           16    5631
NP_877950                                                              16    7355
NP_689616                                                              16    7355
NP_001192230                                                           16    7355
XP_006714503                                                           16    7355
NP_001135938                                                           16    7355
NP_597700                                                              16    7355
NP_001165881                                                           15    9605
NP_001165828                                                           15    9605
NP_001416                                                              15    9605
NP_003009                                                              15    9605
NP_008835                                                              15    9605
NP_001075109                                                           15    9605
NP_001074295                                                           15    9605
NP_620598                                                              15    9605
NP_079052                                                              15    9605
NP_620599                                                              15    9605
NP_004348                                                              15    9605
NP_001034579                                                           15    9605
NP_055826                                                              15    9605
NP_001185879                                                           15    9605
NP_443188                                                              15    9605
NP_937822                                                              15    9605
XP_006721081                                                           15    9605
XP_005255143                                                           15    9605
XP_006721080                                                           15    9605
XP_006721079                                                           15    9605
XP_005255141                                                           15    9605
XP_005254732                                                           15    9605
XP_005254731                                                           15    9605
XP_006720754                                                           15    9605
XP_005254729                                                           15    9605
XP_005254730                                                           15    9605
XP_005254728                                                           15    9605
XP_005254727                                                           15    9605
XP_006716443                                                           15    9605
XP_006716442                                                           15    9605
XP_005273655                                                           15    9605
XP_005272427                                                           15    9605
XP_005272426                                                           15    9605
>NP_000305
          Length = 403

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RTGVMIYAY 9
           RTGVMI AY
Sbjct: 130 RTGVMICAY 138
>XP_006717990
          Length = 175

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RTGVMIYAY 9
           RTGVMI AY
Sbjct: 115 RTGVMICAY 123
>XP_006717989
          Length = 388

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RTGVMIYAY 9
           RTGVMI AY
Sbjct: 115 RTGVMICAY 123
>NP_001269607
          Length = 1075

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 666 RTGILLY 672
>NP_001269606
          Length = 1226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 817 RTGILLY 823
>NP_000457
          Length = 1283

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 874 RTGILLY 880
>NP_000444
          Length = 643

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TGVMIYA 8
           TG++IYA
Sbjct: 145 TGIVIYA 151
>NP_666018
          Length = 610

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TGVMIYA 8
           TG++IYA
Sbjct: 143 TGIVIYA 149
>NP_078863
          Length = 277

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GVMIYAY 9
           GVM+Y Y
Sbjct: 116 GVMLYRY 122
>NP_848593
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TGVMIYA 8
           TGV++YA
Sbjct: 139 TGVVVYA 145
>XP_006718220
          Length = 391

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TGVMIYA 8
           TGV++YA
Sbjct: 139 TGVVVYA 145
>XP_006718219
          Length = 417

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TGVMIYA 8
           TGV++YA
Sbjct: 139 TGVVVYA 145
>XP_006718218
          Length = 507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TGVMIYA 8
          TGV++YA
Sbjct: 28 TGVVVYA 34
>XP_005250490
          Length = 700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 291 RTGILLY 297
>XP_005250486
          Length = 1243

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 834 RTGILLY 840
>XP_005271253
          Length = 204

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  GVMIYAY 9
          GVM+Y Y
Sbjct: 43 GVMLYRY 49
>XP_005271252
          Length = 246

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  GVMIYAY 9
          GVM+Y Y
Sbjct: 85 GVMLYRY 91
>XP_005271251
          Length = 247

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  GVMIYAY 9
          GVM+Y Y
Sbjct: 86 GVMLYRY 92
>NP_877950
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GVMIYAY 9
           GV++Y+Y
Sbjct: 414 GVLLYSY 420
>NP_689616
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GVMIYAY 9
           GV++Y+Y
Sbjct: 648 GVLLYSY 654
>NP_001192230
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GVMIYAY 9
           GV++Y+Y
Sbjct: 648 GVLLYSY 654
>XP_006714503
          Length = 848

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   GVMIYAY 9
           GV++Y+Y
Sbjct: 648 GVLLYSY 654
>NP_001135938
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RTGVMI 6
           RTGVMI
Sbjct: 106 RTGVMI 111
>NP_597700
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RTGVMI 6
           RTGVMI
Sbjct: 206 RTGVMI 211
>NP_001165881
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TGVMIYAY 9
           TG+++Y Y
Sbjct: 99  TGLVVYDY 106
>NP_001165828
          Length = 191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TGVMIYAY 9
           TG+++Y Y
Sbjct: 99  TGLVVYDY 106
>NP_001416
          Length = 163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TGVMIYA 8
           TG +IYA
Sbjct: 113 TGALIYA 119
>NP_003009
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TGVMIYAY 9
           TG+++Y Y
Sbjct: 99  TGLVVYDY 106
>NP_008835
          Length = 4128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TGVMIYAY 9
            TGV  Y+Y
Sbjct: 2047 TGVQSYSY 2054
>NP_001075109
          Length = 4097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    TGVMIYAY 9
            TGV  Y+Y
Sbjct: 2047 TGVQSYSY 2054
>NP_001074295
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1256 QTGILIY 1262
>NP_620598
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   GVMIYAY 9
           G++ YAY
Sbjct: 108 GILAYAY 114
>NP_079052
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1594 QTGILIY 1600
>NP_620599
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   GVMIYAY 9
           G++ YAY
Sbjct: 108 GILAYAY 114
>NP_004348
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   GVMIYAY 9
           G++ YAY
Sbjct: 108 GILAYAY 114
>NP_001034579
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   GVMIYAY 9
           G++ YAY
Sbjct: 108 GILAYAY 114
>NP_055826
          Length = 1858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TGVMIYAY 9
           TG  IY Y
Sbjct: 569 TGARIYTY 576
>NP_001185879
          Length = 1880

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   TGVMIYAY 9
           TG  IY Y
Sbjct: 591 TGARIYTY 598
>NP_443188
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 358 RTGLLLY 364
>NP_937822
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TGVMIYA 8
          TGV+I+A
Sbjct: 51 TGVLIFA 57
>XP_006721081
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 138 RTGLLLY 144
>XP_005255143
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 178 RTGLLLY 184
>XP_006721080
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 358 RTGLLLY 364
>XP_006721079
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 358 RTGLLLY 364
>XP_005255141
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   RTGVMIY 7
           RTG+++Y
Sbjct: 358 RTGLLLY 364
>XP_005254732
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1594 QTGILIY 1600
>XP_005254731
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1594 QTGILIY 1600
>XP_006720754
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1594 QTGILIY 1600
>XP_005254729
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1594 QTGILIY 1600
>XP_005254730
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1594 QTGILIY 1600
>XP_005254728
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1594 QTGILIY 1600
>XP_005254727
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1594 QTGILIY 1600
>XP_006716443
          Length = 191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TGVMIYAY 9
           TG+++Y Y
Sbjct: 99  TGLVVYDY 106
>XP_006716442
          Length = 191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TGVMIYAY 9
           TG+++Y Y
Sbjct: 99  TGLVVYDY 106
>XP_005273655
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   TGVMIYAY 9
           TG+++Y Y
Sbjct: 148 TGLVVYDY 155
>XP_005272427
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1256 QTGILIY 1262
>XP_005272426
          Length = 1406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    RTGVMIY 7
            +TG++IY
Sbjct: 1256 QTGILIY 1262
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.145    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 395,290
Number of extensions: 699
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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