Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              19     665
NP_115532                                                              18    1935
NP_076414                                                              18    1935
NP_001002259                                                           18    1935
NP_001193785                                                           18    1935
XP_006719211                                                           18    1935
XP_006719210                                                           18    1935
XP_006719209                                                           18    1935
XP_006719208                                                           18    1935
XP_006719207                                                           18    1935
XP_006719206                                                           18    1935
XP_006719205                                                           18    1935
XP_006719204                                                           18    1935
XP_006719203                                                           18    1935
XP_006719202                                                           18    1935
XP_006719201                                                           18    1935
XP_006719200                                                           18    1935
NP_060060                                                              17    3301
NP_001271165                                                           17    4312
NP_001098721                                                           17    4312
NP_055548                                                              17    4312
NP_001271166                                                           17    4312
NP_877435                                                              17    4312
XP_005248691                                                           17    4312
XP_005248689                                                           17    4312
NP_031371                                                              16    5631
NP_004801                                                              16    5631
NP_001019784                                                           16    5631
NP_001153736                                                           16    5631
NP_001274666                                                           16    5631
XP_005276776                                                           16    5631
XP_005262564                                                           16    5631
XP_005261898                                                           16    5631
XP_006724439                                                           16    5631
XP_005261893                                                           16    5631
XP_005266819                                                           16    5631
XP_006722604                                                           16    5631
XP_005250394                                                           16    5631
XP_006710324                                                           16    5631
NP_055469                                                              16    7355
NP_001004326                                                           16    7355
NP_057321                                                              16    7355
XP_006719512                                                           16    7355
XP_005253957                                                           16    7355
XP_005274066                                                           16    7355
NP_001124537                                                           16    7355
NP_001124538                                                           16    7355
NP_001131031                                                           16    7355
NP_001349                                                              15    9605
NP_003460                                                              15    9605
NP_110421                                                              15    9605
NP_001139542                                                           15    9605
NP_001139543                                                           15    9605
NP_001245                                                              15    9605
NP_001257403                                                           15    9605
NP_001094094                                                           15    9605
NP_001094095                                                           15    9605
NP_001257402                                                           15    9605
NP_056083                                                              15    9605
NP_055368                                                              15    9605
XP_006721299                                                           15    9605
XP_005266615                                                           15    9605
XP_005247302                                                           15    9605
XP_005263708                                                           15    9605
>NP_115803
          Length = 1156

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RS LPLQQK
Sbjct: 681 RSPLPLQQK 689
>NP_115532
          Length = 960

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>NP_076414
          Length = 1077

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>NP_001002259
          Length = 1127

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>NP_001193785
          Length = 905

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>XP_006719211
          Length = 794

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 117 RSTLPEEQK 125
>XP_006719210
          Length = 940

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>XP_006719209
          Length = 941

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>XP_006719208
          Length = 961

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>XP_006719207
          Length = 1043

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>XP_006719206
          Length = 1046

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 369 RSTLPEEQK 377
>XP_006719205
          Length = 1057

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>XP_006719204
          Length = 1078

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>XP_006719203
          Length = 1091

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>XP_006719202
          Length = 1092

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>XP_006719201
          Length = 1106

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>XP_006719200
          Length = 1126

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           RSTLP +QK
Sbjct: 450 RSTLPEEQK 458
>NP_060060
          Length = 977

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  RSTLPLQQK 9
          +STLPL+Q+
Sbjct: 18 QSTLPLKQE 26
>NP_001271165
          Length = 1539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RSTLPLQQ 8
           +ST+P+QQ
Sbjct: 614 KSTIPVQQ 621
>NP_001098721
          Length = 1539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RSTLPLQQ 8
           +ST+P+QQ
Sbjct: 614 KSTIPVQQ 621
>NP_055548
          Length = 1539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RSTLPLQQ 8
           +ST+P+QQ
Sbjct: 614 KSTIPVQQ 621
>NP_001271166
          Length = 809

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RSTLPLQQ 8
           +ST+P+QQ
Sbjct: 614 KSTIPVQQ 621
>NP_877435
          Length = 1102

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    RSTLPLQ 7
            R+TLPLQ
Sbjct: 1043 RNTLPLQ 1049
>XP_005248691
          Length = 816

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RSTLPLQQ 8
           +ST+P+QQ
Sbjct: 614 KSTIPVQQ 621
>XP_005248689
          Length = 1539

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RSTLPLQQ 8
           +ST+P+QQ
Sbjct: 614 KSTIPVQQ 621
>NP_031371
          Length = 1845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TLPLQQ 8
           TLPLQQ
Sbjct: 332 TLPLQQ 337
>NP_004801
          Length = 330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TLPLQQ 8
           TLPLQQ
Sbjct: 192 TLPLQQ 197
>NP_001019784
          Length = 475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RSTLPLQQ 8
           R  LPLQQ
Sbjct: 133 RDALPLQQ 140
>NP_001153736
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RSTLPLQQ 8
           R  LPLQQ
Sbjct: 133 RDALPLQQ 140
>NP_001274666
          Length = 302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RSTLPLQQK 9
          +S LPLQ+K
Sbjct: 16 QSPLPLQKK 24
>XP_005276776
          Length = 991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSTLPLQ 7
           RSTLPL+
Sbjct: 845 RSTLPLR 851
>XP_005262564
          Length = 991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSTLPLQ 7
           RSTLPL+
Sbjct: 845 RSTLPLR 851
>XP_005261898
          Length = 258

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TLPLQQ 8
           TLPLQQ
Sbjct: 120 TLPLQQ 125
>XP_006724439
          Length = 258

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TLPLQQ 8
           TLPLQQ
Sbjct: 120 TLPLQQ 125
>XP_005261893
          Length = 330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TLPLQQ 8
           TLPLQQ
Sbjct: 192 TLPLQQ 197
>XP_005266819
          Length = 1790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TLPLQQ 8
           TLPLQQ
Sbjct: 277 TLPLQQ 282
>XP_006722604
          Length = 1847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TLPLQQ 8
           TLPLQQ
Sbjct: 334 TLPLQQ 339
>XP_005250394
          Length = 475

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RSTLPLQQ 8
           R  LPLQQ
Sbjct: 133 RDALPLQQ 140
>XP_006710324
          Length = 943

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSTLPLQ 7
           RSTLPL+
Sbjct: 797 RSTLPLR 803
>NP_055469
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RSTLPL 6
           RSTLPL
Sbjct: 273 RSTLPL 278
>NP_001004326
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RSTLPLQQ 8
          R+T+PL Q
Sbjct: 70 RATIPLDQ 77
>NP_057321
          Length = 755

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RSTLPLQQ 8
           RST+ LQQ
Sbjct: 434 RSTMALQQ 441
>XP_006719512
          Length = 357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RSTLPLQQ 8
          RST+ LQQ
Sbjct: 36 RSTMALQQ 43
>XP_005253957
          Length = 742

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RSTLPLQQ 8
           RST+ LQQ
Sbjct: 421 RSTMALQQ 428
>XP_005274066
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RSTLPLQQ 8
          R+T+PL Q
Sbjct: 70 RATIPLDQ 77
>NP_001124537
          Length = 210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  STLPLQ 7
          STLPLQ
Sbjct: 15 STLPLQ 20
>NP_001124538
          Length = 210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  STLPLQ 7
          STLPLQ
Sbjct: 15 STLPLQ 20
>NP_001131031
          Length = 643

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RSTLPLQQ 8
           RST+ LQQ
Sbjct: 322 RSTMALQQ 329
>NP_001349
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STLPLQQK 9
           STLP QQ+
Sbjct: 390 STLPPQQQ 397
>NP_003460
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TLPLQQK 9
          ++PLQQK
Sbjct: 85 SVPLQQK 91
>NP_110421
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RSTLPLQQ 8
           RST P QQ
Sbjct: 635 RSTRPTQQ 642
>NP_001139542
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RSTLPLQQ 8
           RST P QQ
Sbjct: 728 RSTRPTQQ 735
>NP_001139543
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RSTLPLQQ 8
           RST P QQ
Sbjct: 635 RSTRPTQQ 642
>NP_001245
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSTLPLQQK 9
           + + PLQQK
Sbjct: 454 QDSFPLQQK 462
>NP_001257403
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STLPLQQK 9
           ST PLQ++
Sbjct: 184 STTPLQER 191
>NP_001094094
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STLPLQQK 9
           ST PLQ++
Sbjct: 218 STTPLQER 225
>NP_001094095
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STLPLQQK 9
           ST PLQ++
Sbjct: 218 STTPLQER 225
>NP_001257402
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STLPLQQK 9
           ST PLQ++
Sbjct: 198 STTPLQER 205
>NP_056083
          Length = 2243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RSTLPLQ 7
           R+T+PLQ
Sbjct: 952 RATVPLQ 958
>NP_055368
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           ++ +PLQQK
Sbjct: 381 QNRVPLQQK 389
>XP_006721299
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STLPLQQK 9
           ST PLQ++
Sbjct: 218 STTPLQER 225
>XP_005266615
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RSTLPLQQ 8
           RST P QQ
Sbjct: 728 RSTRPTQQ 735
>XP_005247302
          Length = 2248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RSTLPLQ 7
           R+T+PLQ
Sbjct: 957 RATVPLQ 963
>XP_005263708
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSTLPLQQK 9
           ++ +PLQQK
Sbjct: 381 QNRVPLQQK 389
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.123    0.322 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 667,020
Number of extensions: 912
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package