Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243000                                                           19     869
XP_005257603                                                           19     869
XP_006722058                                                           19     869
XP_005257602                                                           19     869
NP_001137357                                                           17    4312
NP_001137358                                                           17    4312
NP_001231921                                                           17    4312
NP_001231919                                                           17    4312
NP_002471                                                              17    4312
NP_444282                                                              17    4312
NP_758954                                                              17    4312
NP_001245140                                                           17    4312
XP_005268950                                                           17    4312
XP_005268949                                                           17    4312
XP_005268948                                                           17    4312
XP_005268946                                                           17    4312
XP_005268944                                                           17    4312
XP_005268945                                                           17    4312
XP_005268943                                                           17    4312
XP_005268942                                                           17    4312
NP_689496                                                              16    5631
NP_001166109                                                           16    5631
XP_005266021                                                           16    5631
XP_006714968                                                           16    5631
XP_005266020                                                           16    5631
NP_112589                                                              16    7355
XP_006711412                                                           16    7355
NP_001258857                                                           15    9605
NP_001258856                                                           15    9605
NP_060046                                                              15    9605
XP_005252149                                                           15    9605
XP_005252148                                                           15    9605
XP_005252147                                                           15    9605
XP_005252146                                                           15    9605
XP_006717239                                                           15    9605
>NP_001243000
          Length = 5207

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSSSLRTR 9
            RSSS+LRTR
Sbjct: 2109 RSSSALRTR 2117
>XP_005257603
          Length = 5256

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSSSLRTR 9
            RSSS+LRTR
Sbjct: 2158 RSSSALRTR 2166
>XP_006722058
          Length = 5256

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSSSLRTR 9
            RSSS+LRTR
Sbjct: 2158 RSSSALRTR 2166
>XP_005257602
          Length = 5256

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSSSLRTR 9
            RSSS+LRTR
Sbjct: 2158 RSSSALRTR 2166
>NP_001137357
          Length = 1030

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>NP_001137358
          Length = 943

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 430 RDSSSLRT 437
>NP_001231921
          Length = 974

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>NP_001231919
          Length = 995

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>NP_002471
          Length = 1030

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>NP_444282
          Length = 780

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   RSSSSLRTR 9
           RSSS++R+R
Sbjct: 365 RSSSTIRSR 373
>NP_758954
          Length = 292

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSSSSLRTR 9
           RSSSSLR +
Sbjct: 200 RSSSSLRKK 208
>NP_001245140
          Length = 280

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSSSSLRTR 9
           RSSSSLR +
Sbjct: 188 RSSSSLRKK 196
>XP_005268950
          Length = 931

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268949
          Length = 987

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268948
          Length = 990

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268946
          Length = 999

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268944
          Length = 1005

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268945
          Length = 1005

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268943
          Length = 1034

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268942
          Length = 1046

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RSSSSLRT 8
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>NP_689496
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RSSSSLR 7
           RSSSSLR
Sbjct: 146 RSSSSLR 152
>NP_001166109
          Length = 900

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RSSSSLR 7
           RSSSSLR
Sbjct: 179 RSSSSLR 185
>XP_005266021
          Length = 786

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RSSSSLR 7
           RSSSSLR
Sbjct: 179 RSSSSLR 185
>XP_006714968
          Length = 804

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RSSSSLR 7
           RSSSSLR
Sbjct: 179 RSSSSLR 185
>XP_005266020
          Length = 835

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   RSSSSLR 7
           RSSSSLR
Sbjct: 179 RSSSSLR 185
>NP_112589
          Length = 268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSSSSLRTR 9
           RSS S+R R
Sbjct: 179 RSSGSMRNR 187
>XP_006711412
          Length = 636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  SSSSLRTR 9
          SSSS RTR
Sbjct: 38 SSSSQRTR 45
>NP_001258857
          Length = 1304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SSSSLRTR 9
            S+SSLRT+
Sbjct: 1185 SASSLRTQ 1192
>NP_001258856
          Length = 1335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SSSSLRTR 9
            S+SSLRT+
Sbjct: 1216 SASSLRTQ 1223
>NP_060046
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SSSSLRTR 9
            S+SSLRT+
Sbjct: 1282 SASSLRTQ 1289
>XP_005252149
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSSSLRTR 9
           S+SSLRT+
Sbjct: 802 SASSLRTQ 809
>XP_005252148
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SSSSLRTR 9
           S+SSLRT+
Sbjct: 924 SASSLRTQ 931
>XP_005252147
          Length = 1329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SSSSLRTR 9
            S+SSLRT+
Sbjct: 1210 SASSLRTQ 1217
>XP_005252146
          Length = 1342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SSSSLRTR 9
            S+SSLRT+
Sbjct: 1223 SASSLRTQ 1230
>XP_006717239
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SSSSLRTR 9
            S+SSLRT+
Sbjct: 1282 SASSLRTQ 1289
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.106    0.234 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 341,643
Number of extensions: 579
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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