Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1482
NP_671714                                                              18    1482
XP_006715890                                                           18    1482
XP_005250160                                                           18    1482
XP_005250159                                                           18    1482
NP_848620                                                              17    3301
NP_001243888                                                           16    5631
NP_001277                                                              16    5631
NP_055798                                                              16    7355
XP_006726463                                                           16    7355
XP_006714828                                                           16    7355
XP_006712963                                                           16    7355
XP_006710204                                                           16    7355
NP_001036111                                                           15    9605
XP_005259549                                                           15    9605
XP_005265016                                                           15    9605
XP_005265015                                                           15    9605
XP_005265014                                                           15    9605
XP_005265013                                                           15    9605

>NP_005742
          Length = 3907

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSESQSSA 9
            RSS+SQSSA
Sbjct: 1759 RSSKSQSSA 1767



>NP_671714
          Length = 3899

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSESQSSA 9
            RSS+SQSSA
Sbjct: 1759 RSSKSQSSA 1767



>XP_006715890
          Length = 3860

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSESQSSA 9
            RSS+SQSSA
Sbjct: 1712 RSSKSQSSA 1720



>XP_005250160
          Length = 3939

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSESQSSA 9
            RSS+SQSSA
Sbjct: 1791 RSSKSQSSA 1799



>XP_005250159
          Length = 3952

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSSESQSSA 9
            RSS+SQSSA
Sbjct: 1791 RSSKSQSSA 1799



>NP_848620
          Length = 416

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  RSSESQSS 8
          +SSESQSS
Sbjct: 7  KSSESQSS 14



>NP_001243888
          Length = 847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   SESQSSA 9
           SESQSSA
Sbjct: 739 SESQSSA 745



>NP_001277
          Length = 869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   SESQSSA 9
           SESQSSA
Sbjct: 761 SESQSSA 767



>NP_055798
          Length = 1292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SSESQSSA 9
           SSES SSA
Sbjct: 272 SSESSSSA 279



>XP_006726463
          Length = 119

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RSSESQSSA 9
          +SSE QSS+
Sbjct: 9  KSSEGQSSS 17



>XP_006714828
          Length = 1126

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SSESQSSA 9
           SSES SSA
Sbjct: 106 SSESSSSA 113



>XP_006712963
          Length = 119

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RSSESQSSA 9
          +SSE QSS+
Sbjct: 9  KSSEGQSSS 17



>XP_006710204
          Length = 119

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RSSESQSSA 9
          +SSE QSS+
Sbjct: 9  KSSEGQSSS 17



>NP_001036111
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSSESQS 7
           RSSESQ+
Sbjct: 828 RSSESQT 834



>XP_005259549
          Length = 1349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SSESQSSA 9
            SSE+QSS+
Sbjct: 1112 SSEAQSSS 1119



>XP_005265016
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSSESQS 7
           RSSESQ+
Sbjct: 724 RSSESQT 730



>XP_005265015
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSSESQS 7
           RSSESQ+
Sbjct: 754 RSSESQT 760



>XP_005265014
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSSESQS 7
           RSSESQ+
Sbjct: 770 RSSESQT 776



>XP_005265013
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSSESQS 7
           RSSESQ+
Sbjct: 807 RSSESQT 813



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.256   0.0733    0.138 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 208,662
Number of extensions: 290
Number of successful extensions: 19
Number of sequences better than 10000.0: 19
Number of HSP's gapped: 19
Number of HSP's successfully gapped: 19
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 19 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.1 bits)
S2: 28 (15.4 bits)