Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           18    1935
NP_000170                                                              18    1935
XP_005264328                                                           18    1935
NP_001191055                                                           17    2528
NP_006143                                                              17    2528
NP_001191056                                                           17    2528
NP_003416                                                              17    2528
XP_005253431                                                           17    2528
XP_006719140                                                           17    2528
XP_006719139                                                           17    2528
XP_005253429                                                           17    2528
XP_006719138                                                           17    2528
XP_005253428                                                           17    2528
XP_005253427                                                           17    2528
NP_003808                                                              17    3301
NP_001131140                                                           17    3301
NP_001116296                                                           17    3301
NP_036247                                                              17    3301
NP_001131139                                                           17    3301
XP_005273730                                                           17    3301
XP_005273729                                                           17    3301
XP_005273728                                                           17    3301
XP_005273727                                                           17    3301
XP_005273726                                                           17    3301
XP_005273725                                                           17    3301
NP_001025054                                                           17    4312
NP_660328                                                              17    4312
NP_001245243                                                           17    4312
XP_005246694                                                           17    4312
NP_942009                                                              16    5631
NP_942011                                                              16    5631
NP_001032240                                                           16    5631
NP_055464                                                              16    7355
XP_005259745                                                           16    7355
NP_848604                                                              15    9605
NP_001073882                                                           15    9605
NP_001238939                                                           15    9605
NP_078898                                                              15    9605
NP_001009909                                                           15    9605
NP_001268405                                                           15    9605
NP_001166923                                                           15    9605
NP_005644                                                              15    9605
NP_001121632                                                           15    9605
NP_689594                                                              15    9605
NP_055368                                                              15    9605
NP_055332                                                              15    9605
NP_000631                                                              15    9605
NP_001238937                                                           15    9605
XP_006721861                                                           15    9605
XP_006721860                                                           15    9605
XP_005257244                                                           15    9605
XP_006720053                                                           15    9605
XP_006720050                                                           15    9605
XP_005252944                                                           15    9605
XP_006712814                                                           15    9605
XP_006712813                                                           15    9605
XP_006712522                                                           15    9605
XP_005263709                                                           15    9605
XP_005263708                                                           15    9605
XP_006712319                                                           15    9605
XP_006712246                                                           15    9605
NP_001186073                                                           15    9605
NP_001121633                                                           15    9605
NP_849146                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RSSCQIKKR 9
           RSS QIKKR
Sbjct: 110 RSSRQIKKR 118
>NP_000170
          Length = 1360

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RSSCQIKKR 9
           RSS QIKKR
Sbjct: 240 RSSRQIKKR 248
>XP_005264328
          Length = 1261

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RSSCQIKKR 9
           RSS QIKKR
Sbjct: 141 RSSRQIKKR 149
>NP_001191055
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQIKKR
Sbjct: 299 CQIKKR 304
>NP_006143
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQIKKR
Sbjct: 299 CQIKKR 304
>NP_001191056
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQIKKR
Sbjct: 299 CQIKKR 304
>NP_003416
          Length = 682

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSSCQIKKR 9
           R+ CQ++KR
Sbjct: 127 RTGCQLEKR 135
>XP_005253431
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQIKKR
Sbjct: 299 CQIKKR 304
>XP_006719140
          Length = 446

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQIKKR
Sbjct: 246 CQIKKR 251
>XP_006719139
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQIKKR
Sbjct: 299 CQIKKR 304
>XP_005253429
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQIKKR
Sbjct: 299 CQIKKR 304
>XP_006719138
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQIKKR
Sbjct: 299 CQIKKR 304
>XP_005253428
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQIKKR
Sbjct: 299 CQIKKR 304
>XP_005253427
          Length = 499

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQIKKR
Sbjct: 299 CQIKKR 304
>NP_003808
          Length = 754

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SCQIKK 8
           SCQIKK
Sbjct: 450 SCQIKK 455
>NP_001131140
          Length = 1982

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    SSCQIKK 8
            SSC++KK
Sbjct: 1803 SSCEVKK 1809
>NP_001116296
          Length = 395

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RSSCQIKK 8
          RS C++KK
Sbjct: 54 RSGCKVKK 61
>NP_036247
          Length = 1982

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    SSCQIKK 8
            SSC++KK
Sbjct: 1803 SSCEVKK 1809
>NP_001131139
          Length = 1982

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    SSCQIKK 8
            SSC++KK
Sbjct: 1803 SSCEVKK 1809
>XP_005273730
          Length = 749

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SCQIKK 8
           SCQIKK
Sbjct: 450 SCQIKK 455
>XP_005273729
          Length = 757

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SCQIKK 8
           SCQIKK
Sbjct: 450 SCQIKK 455
>XP_005273728
          Length = 762

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SCQIKK 8
           SCQIKK
Sbjct: 450 SCQIKK 455
>XP_005273727
          Length = 776

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SCQIKK 8
           SCQIKK
Sbjct: 450 SCQIKK 455
>XP_005273726
          Length = 783

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SCQIKK 8
           SCQIKK
Sbjct: 450 SCQIKK 455
>XP_005273725
          Length = 784

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SCQIKK 8
           SCQIKK
Sbjct: 450 SCQIKK 455
>NP_001025054
          Length = 1288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RSSCQIKK 8
           RSSCQ +K
Sbjct: 912 RSSCQPRK 919
>NP_660328
          Length = 364

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSSCQIKK 8
           + SCQ+KK
Sbjct: 119 QKSCQLKK 126
>NP_001245243
          Length = 501

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SSCQIKKR 9
          S CQI+K+
Sbjct: 25 SKCQIRKK 32
>XP_005246694
          Length = 518

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SSCQIKKR 9
          S CQI+K+
Sbjct: 25 SKCQIRKK 32
>NP_942009
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSSCQIKKR 9
           R  CQ++KR
Sbjct: 355 RKFCQMRKR 363
>NP_942011
          Length = 418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSSCQIKKR 9
           R  CQ++KR
Sbjct: 355 RKFCQMRKR 363
>NP_001032240
          Length = 259

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  SCQIKKR 9
          SC +KKR
Sbjct: 27 SCSLKKR 33
>NP_055464
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   RSSCQIKK 8
           R  C++KK
Sbjct: 495 RKECEVKK 502
>XP_005259745
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  RSSCQIKK 8
          R  C++KK
Sbjct: 41 RKECEVKK 48
>NP_848604
          Length = 553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           SSC+IK
Sbjct: 163 SSCEIK 168
>NP_001073882
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   SCQIKKR 9
           +CQI+K+
Sbjct: 268 TCQIRKK 274
>NP_001238939
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   SSCQIKK 8
           S C++KK
Sbjct: 278 SECEVKK 284
>NP_078898
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSSCQIKK 8
           R+SC IK+
Sbjct: 354 RNSCLIKR 361
>NP_001009909
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   SSCQIKK 8
           S C++KK
Sbjct: 320 SECEVKK 326
>NP_001268405
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSSCQIKK 8
           R+SC IK+
Sbjct: 354 RNSCLIKR 361
>NP_001166923
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           +SCQIK
Sbjct: 231 ASCQIK 236
>NP_005644
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           +SCQIK
Sbjct: 231 ASCQIK 236
>NP_001121632
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           +SCQIK
Sbjct: 228 ASCQIK 233
>NP_689594
          Length = 3549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    RSSCQIKK 8
            +S+C+IK+
Sbjct: 2670 KSACEIKQ 2677
>NP_055368
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           +SCQIK
Sbjct: 211 ASCQIK 216
>NP_055332
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           +SCQIK
Sbjct: 228 ASCQIK 233
>NP_000631
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           SSC+IK
Sbjct: 250 SSCEIK 255
>NP_001238937
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   SSCQIKK 8
           S C++KK
Sbjct: 234 SECEVKK 240
>XP_006721861
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           SSC+IK
Sbjct: 163 SSCEIK 168
>XP_006721860
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           SSC+IK
Sbjct: 165 SSCEIK 170
>XP_005257244
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           SSC+IK
Sbjct: 165 SSCEIK 170
>XP_006720053
          Length = 164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQ+K+R
Sbjct: 153 CQLKRR 158
>XP_006720050
          Length = 195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   CQIKKR 9
           CQ+K+R
Sbjct: 184 CQLKRR 189
>XP_005252944
          Length = 222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   SSCQIKK 8
           S C++KK
Sbjct: 196 SECEVKK 202
>XP_006712814
          Length = 527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RSSCQIKK 8
          R+SC IK+
Sbjct: 34 RNSCLIKR 41
>XP_006712813
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSSCQIKK 8
           R+SC IK+
Sbjct: 331 RNSCLIKR 338
>XP_006712522
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           +SCQIK
Sbjct: 211 ASCQIK 216
>XP_005263709
          Length = 273

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           +SCQIK
Sbjct: 211 ASCQIK 216
>XP_005263708
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           +SCQIK
Sbjct: 211 ASCQIK 216
>XP_006712319
          Length = 3308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    RSSCQIKK 8
            +S+C+IK+
Sbjct: 2429 KSACEIKQ 2436
>XP_006712246
          Length = 443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RSSCQIK 7
           R SCQ+K
Sbjct: 410 RRSCQMK 416
>NP_001186073
          Length = 3327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    RSSCQIKK 8
            +S+C+IK+
Sbjct: 2448 KSACEIKQ 2455
>NP_001121633
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SSCQIK 7
           +SCQIK
Sbjct: 228 ASCQIK 233
>NP_849146
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   SCQIKK 8
           SC++KK
Sbjct: 689 SCEVKK 694
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.123    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 753,706
Number of extensions: 784
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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