Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              17    2528
NP_068804                                                              17    2528
NP_001005407                                                           17    2528
NP_066921                                                              17    2528
XP_006721028                                                           17    2528
XP_006721027                                                           17    2528
XP_005255709                                                           17    2528
XP_006721026                                                           17    2528
XP_005273638                                                           17    3301
XP_005273637                                                           17    3301
XP_005273635                                                           17    3301
XP_005273634                                                           17    3301
NP_064630                                                              17    4312
XP_005267114                                                           17    4312
NP_003471                                                              16    5631
NP_078920                                                              16    5631
XP_006719217                                                           16    5631
XP_005253542                                                           16    5631
NP_079541                                                              16    7355
NP_001186346                                                           16    7355
NP_001138866                                                           16    7355
NP_001138864                                                           16    7355
NP_006030                                                              16    7355
NP_476499                                                              16    7355
XP_006725396                                                           16    7355
XP_006725395                                                           16    7355
XP_006725394                                                           16    7355
XP_006725393                                                           16    7355
XP_006722057                                                           16    7355
XP_006722056                                                           16    7355
XP_006722055                                                           16    7355
XP_006722054                                                           16    7355
XP_005265556                                                           16    7355
XP_005265552                                                           16    7355
NP_001243297                                                           15    9605
NP_001032370                                                           15    9605
NP_443749                                                              15    9605
NP_005873                                                              15    9605
NP_001017405                                                           15    9605
NP_110379                                                              15    9605
NP_001264058                                                           15    9605
NP_001258857                                                           15    9605
NP_001258856                                                           15    9605
NP_002603                                                              15    9605
NP_060046                                                              15    9605
NP_835258                                                              15    9605
NP_055379                                                              15    9605
NP_001264055                                                           15    9605
NP_653288                                                              15    9605
XP_005263467                                                           15    9605
XP_006717241                                                           15    9605
XP_006717240                                                           15    9605
XP_005252147                                                           15    9605
XP_005252146                                                           15    9605
XP_006717239                                                           15    9605
XP_005272028                                                           15    9605
XP_005272027                                                           15    9605
XP_005272026                                                           15    9605
XP_005272025                                                           15    9605
XP_005272024                                                           15    9605
XP_005272300                                                           15    9605
XP_006713914                                                           15    9605
XP_006713913                                                           15    9605
XP_006713912                                                           15    9605
NP_001017372                                                           15    9605
NP_054750                                                              15    9605
>NP_004251
          Length = 1208

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RSRLLCKQA 9
           RSRLL KQA
Sbjct: 370 RSRLLRKQA 378
>NP_068804
          Length = 257

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RSRLLCKQ 8
          RSR LC+Q
Sbjct: 36 RSRCLCRQ 43
>NP_001005407
          Length = 2347

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRLLCKQ 8
            SRLLC+Q
Sbjct: 2004 SRLLCRQ 2010
>NP_066921
          Length = 2353

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRLLCKQ 8
            SRLLC+Q
Sbjct: 2010 SRLLCRQ 2016
>XP_006721028
          Length = 2336

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRLLCKQ 8
            SRLLC+Q
Sbjct: 1993 SRLLCRQ 1999
>XP_006721027
          Length = 2342

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRLLCKQ 8
            SRLLC+Q
Sbjct: 1999 SRLLCRQ 2005
>XP_005255709
          Length = 2347

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRLLCKQ 8
            SRLLC+Q
Sbjct: 2004 SRLLCRQ 2010
>XP_006721026
          Length = 2358

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SRLLCKQ 8
            SRLLC+Q
Sbjct: 2015 SRLLCRQ 2021
>XP_005273638
          Length = 1228

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    RSRLLCK 7
            RSRL CK
Sbjct: 1149 RSRLFCK 1155
>XP_005273637
          Length = 1228

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    RSRLLCK 7
            RSRL CK
Sbjct: 1149 RSRLFCK 1155
>XP_005273635
          Length = 1282

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    RSRLLCK 7
            RSRL CK
Sbjct: 1203 RSRLFCK 1209
>XP_005273634
          Length = 1282

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    RSRLLCK 7
            RSRL CK
Sbjct: 1203 RSRLFCK 1209
>NP_064630
          Length = 1543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSRLLCKQ 8
           R+R+LC Q
Sbjct: 904 RTRMLCSQ 911
>XP_005267114
          Length = 1543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSRLLCKQ 8
           R+R+LC Q
Sbjct: 904 RTRMLCSQ 911
>NP_003471
          Length = 173

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SRLLCKQ 8
           SRL+CK+
Sbjct: 125 SRLVCKE 131
>NP_078920
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RLLCKQA 9
           RLLC QA
Sbjct: 297 RLLCPQA 303
>XP_006719217
          Length = 161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SRLLCKQ 8
           SRL+CK+
Sbjct: 113 SRLVCKE 119
>XP_005253542
          Length = 163

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SRLLCKQ 8
           SRL+CK+
Sbjct: 115 SRLVCKE 121
>NP_079541
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RSRLLCKQ 8
           R+RL+C++
Sbjct: 281 RNRLICRR 288
>NP_001186346
          Length = 1491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRLLCKQA 9
           SRL C+QA
Sbjct: 280 SRLECQQA 287
>NP_001138866
          Length = 406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RSRLLCKQ 8
           R+RL+C++
Sbjct: 222 RNRLICRR 229
>NP_001138864
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RSRLLCKQ 8
           R+RL+C++
Sbjct: 281 RNRLICRR 288
>NP_006030
          Length = 1479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RSRLLCKQA 9
           R+R +C+Q+
Sbjct: 639 RARYICRQS 647
>NP_476499
          Length = 303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RSRLLCKQA 9
          RSR LC ++
Sbjct: 44 RSRCLCSES 52
>XP_006725396
          Length = 1144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRLLCKQA 9
           SRL C+QA
Sbjct: 280 SRLECQQA 287
>XP_006725395
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRLLCKQA 9
           SRL C+QA
Sbjct: 280 SRLECQQA 287
>XP_006725394
          Length = 1408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRLLCKQA 9
           SRL C+QA
Sbjct: 280 SRLECQQA 287
>XP_006725393
          Length = 1473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRLLCKQA 9
           SRL C+QA
Sbjct: 262 SRLECQQA 269
>XP_006722057
          Length = 1144

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRLLCKQA 9
           SRL C+QA
Sbjct: 280 SRLECQQA 287
>XP_006722056
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRLLCKQA 9
           SRL C+QA
Sbjct: 280 SRLECQQA 287
>XP_006722055
          Length = 1408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRLLCKQA 9
           SRL C+QA
Sbjct: 280 SRLECQQA 287
>XP_006722054
          Length = 1473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SRLLCKQA 9
           SRL C+QA
Sbjct: 262 SRLECQQA 269
>XP_005265556
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RSRLLCKQ 8
           R+RL+C++
Sbjct: 281 RNRLICRR 288
>XP_005265552
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RSRLLCKQ 8
           R+RL+C++
Sbjct: 281 RNRLICRR 288
>NP_001243297
          Length = 102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LLCKQA 9
          LLC+QA
Sbjct: 20 LLCRQA 25
>NP_001032370
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RSRLLCKQA 9
           +  +LCK+A
Sbjct: 233 KEHMLCKEA 241
>NP_443749
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RSRLLCKQA 9
           +  +LCK+A
Sbjct: 265 KEHMLCKEA 273
>NP_005873
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SRLLCK 7
           SRL+CK
Sbjct: 295 SRLVCK 300
>NP_001017405
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SRLLCK 7
           SRL+CK
Sbjct: 336 SRLVCK 341
>NP_110379
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RLLCKQA 9
           RL CK+A
Sbjct: 122 RLACKEA 128
>NP_001264058
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RLLCKQ 8
           RLLCK+
Sbjct: 959 RLLCKR 964
>NP_001258857
          Length = 1304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LLCKQA 9
          LLCK+A
Sbjct: 15 LLCKEA 20
>NP_001258856
          Length = 1335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LLCKQA 9
          LLCK+A
Sbjct: 15 LLCKEA 20
>NP_002603
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SRLLCKQ 8
           SR+LC Q
Sbjct: 211 SRMLCDQ 217
>NP_060046
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LLCKQA 9
          LLCK+A
Sbjct: 15 LLCKEA 20
>NP_835258
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SRLLCK 7
           SRL+CK
Sbjct: 137 SRLVCK 142
>NP_055379
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SRLLCK 7
           SRL+CK
Sbjct: 142 SRLVCK 147
>NP_001264055
          Length = 1062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    RLLCKQ 8
            RLLCK+
Sbjct: 1017 RLLCKR 1022
>NP_653288
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    RLLCKQ 8
            RLLCK+
Sbjct: 1016 RLLCKR 1021
>XP_005263467
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SRLLCK 7
           SRL+CK
Sbjct: 126 SRLVCK 131
>XP_006717241
          Length = 1136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LLCKQA 9
          LLCK+A
Sbjct: 15 LLCKEA 20
>XP_006717240
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LLCKQA 9
          LLCK+A
Sbjct: 15 LLCKEA 20
>XP_005252147
          Length = 1329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LLCKQA 9
          LLCK+A
Sbjct: 15 LLCKEA 20
>XP_005252146
          Length = 1342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LLCKQA 9
          LLCK+A
Sbjct: 15 LLCKEA 20
>XP_006717239
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LLCKQA 9
          LLCK+A
Sbjct: 15 LLCKEA 20
>XP_005272028
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RLLCKQA 9
           R LCKQ+
Sbjct: 316 RYLCKQS 322
>XP_005272027
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RLLCKQA 9
           R LCKQ+
Sbjct: 316 RYLCKQS 322
>XP_005272026
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RLLCKQA 9
           R LCKQ+
Sbjct: 316 RYLCKQS 322
>XP_005272025
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RLLCKQA 9
           R LCKQ+
Sbjct: 316 RYLCKQS 322
>XP_005272024
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RLLCKQA 9
           R LCKQ+
Sbjct: 316 RYLCKQS 322
>XP_005272300
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SRLLCK 7
           SRL+CK
Sbjct: 335 SRLVCK 340
>XP_006713914
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SRLLCK 7
           SRL+CK
Sbjct: 288 SRLVCK 293
>XP_006713913
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SRLLCK 7
           SRL+CK
Sbjct: 335 SRLVCK 340
>XP_006713912
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SRLLCK 7
           SRL+CK
Sbjct: 336 SRLVCK 341
>NP_001017372
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RLLCKQA 9
           R LCKQ+
Sbjct: 316 RYLCKQS 322
>NP_054750
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RLLCKQA 9
           R LCKQ+
Sbjct: 316 RYLCKQS 322
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.133    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 657,427
Number of extensions: 784
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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