Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              21     229
XP_006718908                                                           21     229
XP_005271621                                                           21     229
XP_006718907                                                           21     229
XP_006718906                                                           21     229
XP_005271619                                                           21     229
XP_005271618                                                           21     229
NP_001119576                                                           17    3301
NP_037409                                                              17    3301
NP_001119575                                                           17    3301
XP_006719423                                                           17    3301
XP_006719422                                                           17    3301
XP_005268873                                                           17    3301
XP_005268872                                                           17    3301
XP_005268870                                                           17    3301
XP_005268871                                                           17    3301
XP_005268869                                                           17    3301
XP_005268868                                                           17    3301
NP_689484                                                              16    5631
XP_005273742                                                           16    5631
NP_002408                                                              16    7355
NP_001139438                                                           16    7355
NP_057191                                                              16    7355
NP_079460                                                              16    7355
XP_006724625                                                           16    7355
XP_006724624                                                           16    7355
XP_005272728                                                           16    7355
XP_006717927                                                           16    7355
XP_006714540                                                           16    7355
NP_001933                                                              15    9605
NP_001017423                                                           15    9605
NP_002851                                                              15    9605
NP_055872                                                              15    9605
NP_078813                                                              15    9605
NP_085126                                                              15    9605
NP_001136116                                                           15    9605
NP_055464                                                              15    9605
NP_003137                                                              15    9605
XP_005259745                                                           15    9605
XP_006720016                                                           15    9605
XP_006719852                                                           15    9605
XP_005266357                                                           15    9605
XP_006719851                                                           15    9605
XP_006719850                                                           15    9605
XP_006719849                                                           15    9605
XP_006719848                                                           15    9605
XP_005266356                                                           15    9605
XP_006719847                                                           15    9605
XP_006719846                                                           15    9605
XP_006719845                                                           15    9605
XP_006719844                                                           15    9605
XP_006719843                                                           15    9605
XP_006719842                                                           15    9605
XP_005274251                                                           15    9605
XP_006717996                                                           15    9605
XP_005246927                                                           15    9605
XP_005246925                                                           15    9605
XP_006712841                                                           15    9605
XP_005246924                                                           15    9605
XP_006712840                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSRITKNMP 9
            RSRITKN+P
Sbjct: 2580 RSRITKNVP 2588
>XP_006718908
          Length = 1708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSRITKNMP 9
            RSRITKN+P
Sbjct: 1232 RSRITKNVP 1240
>XP_005271621
          Length = 2708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSRITKNMP 9
            RSRITKN+P
Sbjct: 2232 RSRITKNVP 2240
>XP_006718907
          Length = 3050

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSRITKNMP 9
            RSRITKN+P
Sbjct: 2574 RSRITKNVP 2582
>XP_006718906
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSRITKNMP 9
            RSRITKN+P
Sbjct: 2580 RSRITKNVP 2588
>XP_005271619
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSRITKNMP 9
            RSRITKN+P
Sbjct: 2580 RSRITKNVP 2588
>XP_005271618
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RSRITKNMP 9
            RSRITKN+P
Sbjct: 2580 RSRITKNVP 2588
>NP_001119576
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 599 RSTLTKNTP 607
>NP_037409
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 599 RSTLTKNTP 607
>NP_001119575
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 599 RSTLTKNTP 607
>XP_006719423
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 599 RSTLTKNTP 607
>XP_006719422
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 599 RSTLTKNTP 607
>XP_005268873
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 599 RSTLTKNTP 607
>XP_005268872
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 599 RSTLTKNTP 607
>XP_005268870
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 599 RSTLTKNTP 607
>XP_005268871
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 599 RSTLTKNTP 607
>XP_005268869
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 599 RSTLTKNTP 607
>XP_005268868
          Length = 651

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS +TKN P
Sbjct: 618 RSTLTKNTP 626
>NP_689484
          Length = 773

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRITKNMP 9
           S +TKN+P
Sbjct: 562 SHLTKNVP 569
>XP_005273742
          Length = 762

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRITKNMP 9
           S +TKN+P
Sbjct: 551 SHLTKNVP 558
>NP_002408
          Length = 3256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RSRITKNMP 9
            RSR TK+ P
Sbjct: 3201 RSRKTKSQP 3209
>NP_001139438
          Length = 2896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RSRITKNMP 9
            RSR TK+ P
Sbjct: 2841 RSRKTKSQP 2849
>NP_057191
          Length = 1074

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRITKNMP 9
           SRI +N+P
Sbjct: 822 SRIAENLP 829
>NP_079460
          Length = 749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS++ KN P
Sbjct: 281 RSKLPKNCP 289
>XP_006724625
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RSRITKNMP 9
          RS++ KN P
Sbjct: 85 RSKLPKNCP 93
>XP_006724624
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS++ KN P
Sbjct: 205 RSKLPKNCP 213
>XP_005272728
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RSRITKNMP 9
           RS++ KN P
Sbjct: 281 RSKLPKNCP 289
>XP_006717927
          Length = 2406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RSRITKNMP 9
            RSR TK+ P
Sbjct: 2351 RSRKTKSQP 2359
>XP_006714540
          Length = 1030

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SRITKNMP 9
           SRI +N+P
Sbjct: 778 SRIAENLP 785
>NP_001933
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    RSRITK 6
            RSRITK
Sbjct: 1036 RSRITK 1041
>NP_001017423
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSRITKNM 8
           R+RI KN+
Sbjct: 455 RTRIAKNL 462
>NP_002851
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSRITKNM 8
           R+RI KN+
Sbjct: 457 RTRIAKNL 464
>NP_055872
          Length = 4678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4192 SRVTKN 4197
>NP_078813
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RITKNMP 9
           R+T+N+P
Sbjct: 164 RVTENIP 170
>NP_085126
          Length = 1671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SRITKNMP 9
            SR+T N+P
Sbjct: 1247 SRLTVNVP 1254
>NP_001136116
          Length = 1700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SRITKNMP 9
            SR+T N+P
Sbjct: 1247 SRLTVNVP 1254
>NP_055464
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RSRITKN 7
           RSR+TK+
Sbjct: 557 RSRVTKS 563
>NP_003137
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RITKNM 8
           R+TKNM
Sbjct: 301 RLTKNM 306
>XP_005259745
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RSRITKN 7
           RSR+TK+
Sbjct: 103 RSRVTKS 109
>XP_006720016
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  RITKNMP 9
          R+T+N+P
Sbjct: 51 RVTENIP 57
>XP_006719852
          Length = 4752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4266 SRVTKN 4271
>XP_005266357
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4114 SRVTKN 4119
>XP_006719851
          Length = 4689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4203 SRVTKN 4208
>XP_006719850
          Length = 4697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4211 SRVTKN 4216
>XP_006719849
          Length = 4703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4217 SRVTKN 4222
>XP_006719848
          Length = 4737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4251 SRVTKN 4256
>XP_005266356
          Length = 4755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4269 SRVTKN 4274
>XP_006719847
          Length = 4761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4275 SRVTKN 4280
>XP_006719846
          Length = 4763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4277 SRVTKN 4282
>XP_006719845
          Length = 4772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4286 SRVTKN 4291
>XP_006719844
          Length = 4789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4303 SRVTKN 4308
>XP_006719843
          Length = 4794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4308 SRVTKN 4313
>XP_006719842
          Length = 4797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SRITKN 7
            SR+TKN
Sbjct: 4311 SRVTKN 4316
>XP_005274251
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RITKNM 8
           R+TKNM
Sbjct: 301 RLTKNM 306
>XP_006717996
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSRITKNM 8
           R+RI KN+
Sbjct: 457 RTRIAKNL 464
>XP_005246927
          Length = 1683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SRITKNMP 9
            SR+T N+P
Sbjct: 1230 SRLTVNVP 1237
>XP_005246925
          Length = 1696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SRITKNMP 9
            SR+T N+P
Sbjct: 1243 SRLTVNVP 1250
>XP_006712841
          Length = 1696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SRITKNMP 9
            SR+T N+P
Sbjct: 1272 SRLTVNVP 1279
>XP_005246924
          Length = 1713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SRITKNMP 9
            SR+T N+P
Sbjct: 1260 SRLTVNVP 1267
>XP_006712840
          Length = 1725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SRITKNMP 9
            SR+T N+P
Sbjct: 1272 SRLTVNVP 1279
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.126    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 413,025
Number of extensions: 656
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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