Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167558                                                           19     869
NP_858045                                                              19     869
NP_006525                                                              19     869
NP_001167559                                                           19     869
NP_001231498                                                           17    4312
NP_932071                                                              17    4312
NP_001231496                                                           17    4312
NP_001187                                                              17    4312
NP_001231499                                                           17    4312
NP_001231501                                                           17    4312
NP_932070                                                              17    4312
NP_976249                                                              16    5631
NP_056261                                                              16    7355
NP_060082                                                              16    7355
NP_056075                                                              16    7355
NP_001138505                                                           16    7355
XP_006722767                                                           16    7355
XP_005259889                                                           16    7355
XP_006719555                                                           16    7355
XP_005253638                                                           16    7355
XP_006719554                                                           16    7355
XP_006711822                                                           16    7355
XP_006711821                                                           16    7355
NP_001258941                                                           15    9605
NP_001451                                                              15    9605
NP_203755                                                              15    9605
NP_001258942                                                           15    9605
NP_000017                                                              15    9605
NP_055817                                                              15    9605
NP_296373                                                              15    9605
NP_940931                                                              15    9605
NP_001138525                                                           15    9605
XP_005276312                                                           15    9605
XP_006721944                                                           15    9605
XP_006721943                                                           15    9605
XP_006721942                                                           15    9605
XP_005270314                                                           15    9605
XP_005263448                                                           15    9605
XP_005245096                                                           15    9605
XP_005276022                                                           15    9605
NP_001116850                                                           15    9605
NP_002207                                                              15    9605
>NP_001167558
          Length = 1423

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RSLLRNSLD 9
            R LLRNSLD
Sbjct: 1027 RPLLRNSLD 1035
>NP_858045
          Length = 1424

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RSLLRNSLD 9
            R LLRNSLD
Sbjct: 1027 RPLLRNSLD 1035
>NP_006525
          Length = 1420

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RSLLRNSLD 9
            R LLRNSLD
Sbjct: 1027 RPLLRNSLD 1035
>NP_001167559
          Length = 1415

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RSLLRNSLD 9
            R LLRNSLD
Sbjct: 1022 RPLLRNSLD 1030
>NP_001231498
          Length = 99

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RSLLRNSLD 9
          RSL RN +D
Sbjct: 91 RSLARNGMD 99
>NP_932071
          Length = 99

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RSLLRNSLD 9
          RSL RN +D
Sbjct: 91 RSLARNGMD 99
>NP_001231496
          Length = 195

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSLLRNSLD 9
           RSL RN +D
Sbjct: 187 RSLARNGMD 195
>NP_001187
          Length = 195

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSLLRNSLD 9
           RSL RN +D
Sbjct: 187 RSLARNGMD 195
>NP_001231499
          Length = 99

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RSLLRNSLD 9
          RSL RN +D
Sbjct: 91 RSLARNGMD 99
>NP_001231501
          Length = 99

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RSLLRNSLD 9
          RSL RN +D
Sbjct: 91 RSLARNGMD 99
>NP_932070
          Length = 241

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSLLRNSLD 9
           RSL RN +D
Sbjct: 233 RSLARNGMD 241
>NP_976249
          Length = 211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RSLLRNSLD 9
           RSLL+ +LD
Sbjct: 170 RSLLKETLD 178
>NP_056261
          Length = 2275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RSLLRNSL 8
            RSL RNS+
Sbjct: 998  RSLARNSI 1005
>NP_060082
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSLLRNS 7
           RSLL+NS
Sbjct: 689 RSLLKNS 695
>NP_056075
          Length = 1162

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSLLRNSLD 9
           RSLL  S+D
Sbjct: 856 RSLLEGSID 864
>NP_001138505
          Length = 122

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LRNSLD 9
           LRNSLD
Sbjct: 109 LRNSLD 114
>XP_006722767
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSLLRNSLD 9
           RSLL  S+D
Sbjct: 339 RSLLEGSID 347
>XP_005259889
          Length = 1130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSLLRNSLD 9
           RSLL  S+D
Sbjct: 824 RSLLEGSID 832
>XP_006719555
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSLLRNS 7
           RSLL+NS
Sbjct: 451 RSLLKNS 457
>XP_005253638
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSLLRNS 7
           RSLL+NS
Sbjct: 451 RSLLKNS 457
>XP_006719554
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RSLLRNS 7
           RSLL+NS
Sbjct: 612 RSLLKNS 618
>XP_006711822
          Length = 2266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RSLLRNSL 8
           RSL RNS+
Sbjct: 989 RSLARNSI 996
>XP_006711821
          Length = 2301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RSLLRNSL 8
            RSL RNS+
Sbjct: 1024 RSLARNSI 1031
>NP_001258941
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSLLRNSLD 9
           RSL R +LD
Sbjct: 510 RSLYRKTLD 518
>NP_001451
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RSLLRNSL 8
           RS+LRN L
Sbjct: 240 RSMLRNVL 247
>NP_203755
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSLLRNSLD 9
           RSL R +LD
Sbjct: 510 RSLYRKTLD 518
>NP_001258942
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSLLRNSLD 9
           RSL R +LD
Sbjct: 510 RSLYRKTLD 518
>NP_000017
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LLRNSLD 9
           +LRN+LD
Sbjct: 123 ILRNALD 129
>NP_055817
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLRNSLD 9
           LLR+SLD
Sbjct: 407 LLRDSLD 413
>NP_296373
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LLRNSLD 9
           LLR+SLD
Sbjct: 407 LLRDSLD 413
>NP_940931
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RSLLRN 6
           RSLLRN
Sbjct: 425 RSLLRN 430
>NP_001138525
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RSLLRN 6
           RSLLRN
Sbjct: 369 RSLLRN 374
>XP_005276312
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LLRNSLD 9
          LLR+SLD
Sbjct: 6  LLRHSLD 12
>XP_006721944
          Length = 1232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RSLLRN 6
           RSLLRN
Sbjct: 425 RSLLRN 430
>XP_006721943
          Length = 1456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RSLLRN 6
           RSLLRN
Sbjct: 425 RSLLRN 430
>XP_006721942
          Length = 1503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RSLLRN 6
           RSLLRN
Sbjct: 425 RSLLRN 430
>XP_005270314
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSLLRNSLD 9
           RSL R +LD
Sbjct: 515 RSLYRKTLD 523
>XP_005263448
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LLRNSLD 9
          LLR+SLD
Sbjct: 6  LLRHSLD 12
>XP_005245096
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RSLLRNSL 8
           RS+LRN L
Sbjct: 240 RSMLRNVL 247
>XP_005276022
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LLRNSLD 9
          LLR+SLD
Sbjct: 6  LLRHSLD 12
>NP_001116850
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LLRNSLD 9
           +LRN+LD
Sbjct: 123 ILRNALD 129
>NP_002207
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RSLLRNSLD 9
           RS+L+ SLD
Sbjct: 610 RSILQMSLD 618
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.135    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 385,054
Number of extensions: 473
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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