Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              20     509
XP_006726471                                                           17    4312
XP_006710212                                                           17    4312
NP_055504                                                              16    7355
NP_001277192                                                           16    7355
NP_006627                                                              16    7355
NP_789784                                                              16    7355
NP_065928                                                              16    7355
NP_001138450                                                           16    7355
XP_005256527                                                           16    7355
XP_005250238                                                           16    7355
XP_005250236                                                           16    7355
XP_006715932                                                           16    7355
XP_006715931                                                           16    7355
XP_006715930                                                           16    7355
XP_005265749                                                           16    7355
XP_005265748                                                           16    7355
XP_005265747                                                           16    7355
XP_006712687                                                           16    7355
XP_006712686                                                           16    7355
XP_006712685                                                           16    7355
XP_006712684                                                           16    7355
XP_006712683                                                           16    7355
XP_006712682                                                           16    7355
XP_006712681                                                           16    7355
XP_005246730                                                           16    7355
XP_005246729                                                           16    7355
XP_006712680                                                           16    7355
XP_006712679                                                           16    7355
XP_006711987                                                           16    7355
NP_000436                                                              15    9605
NP_958780                                                              15    9605
NP_958781                                                              15    9605
NP_958785                                                              15    9605
NP_958783                                                              15    9605
NP_958786                                                              15    9605
NP_073572                                                              15    9605
NP_958782                                                              15    9605
NP_958784                                                              15    9605
NP_006157                                                              15    9605
XP_005268966                                                           15    9605
XP_005268967                                                           15    9605
XP_005268965                                                           15    9605
XP_006716654                                                           15    9605
XP_005251041                                                           15    9605
XP_005251040                                                           15    9605
XP_006716653                                                           15    9605
XP_006716652                                                           15    9605
XP_005251039                                                           15    9605
XP_005251038                                                           15    9605
XP_005251036                                                           15    9605
XP_005251037                                                           15    9605
XP_005251035                                                           15    9605
XP_006716651                                                           15    9605
XP_005251034                                                           15    9605
XP_005251033                                                           15    9605
>NP_002430
          Length = 1137

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSKSIY PL
Sbjct: 224 RSKSIYTPL 232
>XP_006726471
          Length = 249

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RS+++Y PL
Sbjct: 116 RSRTLYCPL 124
>XP_006710212
          Length = 249

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RS+++Y PL
Sbjct: 116 RSRTLYCPL 124
>NP_055504
          Length = 2186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1203 SLYMPL 1208
>NP_001277192
          Length = 2180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1197 SLYMPL 1202
>NP_006627
          Length = 350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ MP+
Sbjct: 201 RSKNVGMPI 209
>NP_789784
          Length = 664

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ +PL
Sbjct: 277 RSKNVLVPL 285
>NP_065928
          Length = 4427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    RSKSIYMP 8
            R+K +Y+P
Sbjct: 2465 RTKGVYVP 2472
>NP_001138450
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ MP+
Sbjct: 215 RSKNVGMPI 223
>XP_005256527
          Length = 4427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    RSKSIYMP 8
            R+K +Y+P
Sbjct: 2465 RTKGVYVP 2472
>XP_005250238
          Length = 664

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ +PL
Sbjct: 277 RSKNVLVPL 285
>XP_005250236
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ +PL
Sbjct: 277 RSKNVLVPL 285
>XP_006715932
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ +PL
Sbjct: 245 RSKNVLVPL 253
>XP_006715931
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ +PL
Sbjct: 277 RSKNVLVPL 285
>XP_006715930
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ +PL
Sbjct: 277 RSKNVLVPL 285
>XP_005265749
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ MP+
Sbjct: 157 RSKNVGMPI 165
>XP_005265748
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ MP+
Sbjct: 157 RSKNVGMPI 165
>XP_005265747
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ MP+
Sbjct: 157 RSKNVGMPI 165
>XP_006712687
          Length = 2166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712686
          Length = 2173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712685
          Length = 2175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712684
          Length = 2189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1197 SLYMPL 1202
>XP_006712683
          Length = 2195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1203 SLYMPL 1208
>XP_006712682
          Length = 2199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712681
          Length = 2199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_005246730
          Length = 2199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_005246729
          Length = 2201

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712680
          Length = 2206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712679
          Length = 2208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    SIYMPL 9
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006711987
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSKSIYMPL 9
           RSK++ MP+
Sbjct: 99  RSKNVGMPI 107
>NP_000436
          Length = 4574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 365 RSKGIYQSL 373
>NP_958780
          Length = 4533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 324 RSKGIYQSL 332
>NP_958781
          Length = 4525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 316 RSKGIYQSL 324
>NP_958785
          Length = 4551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 342 RSKGIYQSL 350
>NP_958783
          Length = 4515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 306 RSKGIYQSL 314
>NP_958786
          Length = 4547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 338 RSKGIYQSL 346
>NP_073572
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RSKSIY 6
           RSKS+Y
Sbjct: 516 RSKSVY 521
>NP_958782
          Length = 4684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 475 RSKGIYQSL 483
>NP_958784
          Length = 4547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 338 RSKGIYQSL 346
>NP_006157
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  RSKSIYMPL 9
          R + IY+P+
Sbjct: 53 REQDIYLPI 61
>XP_005268966
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  RSKSIYMPL 9
          R + IY+P+
Sbjct: 54 REQDIYLPI 62
>XP_005268967
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  RSKSIYMPL 9
          R + IY+P+
Sbjct: 54 REQDIYLPI 62
>XP_005268965
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  RSKSIYMPL 9
          R + IY+P+
Sbjct: 54 REQDIYLPI 62
>XP_006716654
          Length = 3562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 480 RSKGIYQSL 488
>XP_005251041
          Length = 4520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 311 RSKGIYQSL 319
>XP_005251040
          Length = 4524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 315 RSKGIYQSL 323
>XP_006716653
          Length = 4529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 320 RSKGIYQSL 328
>XP_006716652
          Length = 4529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 320 RSKGIYQSL 328
>XP_005251039
          Length = 4530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 321 RSKGIYQSL 329
>XP_005251038
          Length = 4538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 329 RSKGIYQSL 337
>XP_005251036
          Length = 4552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 343 RSKGIYQSL 351
>XP_005251037
          Length = 4552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 343 RSKGIYQSL 351
>XP_005251035
          Length = 4556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 347 RSKGIYQSL 355
>XP_006716651
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 370 RSKGIYQSL 378
>XP_005251034
          Length = 4685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 476 RSKGIYQSL 484
>XP_005251033
          Length = 4689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RSKSIYMPL 9
           RSK IY  L
Sbjct: 480 RSKGIYQSL 488
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.134    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 463,477
Number of extensions: 740
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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