Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              19     665
NP_444254                                                              19     665
NP_444253                                                              19     665
NP_444255                                                              19     665
XP_005247551                                                           19     665
XP_005247550                                                           19     665
XP_006713712                                                           19     665
XP_005247549                                                           19     665
NP_653320                                                              17    2528
XP_005264956                                                           17    2528
XP_005264955                                                           17    2528
NP_001093869                                                           17    4312
NP_056453                                                              17    4312
NP_955400                                                              17    4312
XP_005262709                                                           17    4312
NP_057412                                                              16    5631
XP_006716247                                                           16    5631
XP_005250778                                                           16    5631
XP_005244984                                                           16    5631
NP_004706                                                              16    7355
NP_001189433                                                           16    7355
NP_430255                                                              16    7355
NP_001424                                                              16    7355
NP_001229794                                                           16    7355
NP_001099038                                                           16    7355
NP_001229793                                                           16    7355
NP_001099037                                                           16    7355
NP_001099036                                                           16    7355
NP_001273607                                                           16    7355
NP_001273606                                                           16    7355
NP_001273605                                                           16    7355
NP_071396                                                              16    7355
NP_996845                                                              16    7355
NP_001526                                                              16    7355
NP_001229795                                                           16    7355
XP_006724063                                                           16    7355
XP_006724062                                                           16    7355
XP_006724061                                                           16    7355
XP_005261168                                                           16    7355
XP_006722637                                                           16    7355
XP_005266839                                                           16    7355
XP_006721832                                                           16    7355
XP_006715230                                                           16    7355
XP_006715229                                                           16    7355
XP_005249350                                                           16    7355
XP_005249349                                                           16    7355
XP_005249348                                                           16    7355
XP_005249347                                                           16    7355
XP_005249346                                                           16    7355
NP_954635                                                              15    9605
NP_000679                                                              15    9605
NP_001265204                                                           15    9605
NP_937987                                                              15    9605
NP_997705                                                              15    9605
NP_001265205                                                           15    9605
NP_001265206                                                           15    9605
NP_001265207                                                           15    9605
NP_001128119                                                           15    9605
NP_940997                                                              15    9605
XP_005248564                                                           15    9605
XP_006713973                                                           15    9605
XP_006713972                                                           15    9605
XP_006713971                                                           15    9605
XP_005265002                                                           15    9605
XP_005265001                                                           15    9605
XP_005246212                                                           15    9605
XP_005246211                                                           15    9605
NP_005900                                                              15    9605
>NP_444256
          Length = 1794

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSESQGTA
Sbjct: 1021 RSESQGTA 1028
>NP_444254
          Length = 1845

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSESQGTA
Sbjct: 1021 RSESQGTA 1028
>NP_444253
          Length = 1914

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSESQGTA
Sbjct: 1090 RSESQGTA 1097
>NP_444255
          Length = 1863

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSESQGTA
Sbjct: 1090 RSESQGTA 1097
>XP_005247551
          Length = 1855

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSESQGTA
Sbjct: 1031 RSESQGTA 1038
>XP_005247550
          Length = 1856

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSESQGTA
Sbjct: 1100 RSESQGTA 1107
>XP_006713712
          Length = 1923

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSESQGTA
Sbjct: 1100 RSESQGTA 1107
>XP_005247549
          Length = 1924

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSESQGTA
Sbjct: 1100 RSESQGTA 1107
>NP_653320
          Length = 715

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSESQGTAS 9
           RS+S GTAS
Sbjct: 287 RSQSAGTAS 295
>XP_005264956
          Length = 463

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSESQGTAS 9
           RS+S GTAS
Sbjct: 287 RSQSAGTAS 295
>XP_005264955
          Length = 674

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RSESQGTAS 9
           RS+S GTAS
Sbjct: 287 RSQSAGTAS 295
>NP_001093869
          Length = 1337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RSESQGTAS 9
            +SESQG A+
Sbjct: 1275 KSESQGNAT 1283
>NP_056453
          Length = 797

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SESQGTAS 9
           SES GTAS
Sbjct: 310 SESTGTAS 317
>NP_955400
          Length = 789

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SESQGTAS 9
           SES GTAS
Sbjct: 310 SESTGTAS 317
>XP_005262709
          Length = 1337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RSESQGTAS 9
            +SESQG A+
Sbjct: 1275 KSESQGNAT 1283
>NP_057412
          Length = 959

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESQGTAS 9
           +SQGTAS
Sbjct: 653 DSQGTAS 659
>XP_006716247
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESQGTAS 9
           +SQGTAS
Sbjct: 332 DSQGTAS 338
>XP_005250778
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESQGTAS 9
           +SQGTAS
Sbjct: 653 DSQGTAS 659
>XP_005244984
          Length = 496

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ESQGTAS 9
           ES+GTAS
Sbjct: 441 ESEGTAS 447
>NP_004706
          Length = 961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SESQGTAS 9
           SES+GT S
Sbjct: 462 SESEGTKS 469
>NP_001189433
          Length = 842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SESQGTAS 9
           SES+GT S
Sbjct: 343 SESEGTKS 350
>NP_430255
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SESQGTAS 9
           SES+GT S
Sbjct: 462 SESEGTKS 469
>NP_001424
          Length = 977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SESQGTAS 9
           SES GT+S
Sbjct: 518 SESSGTSS 525
>NP_001229794
          Length = 284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>NP_001099038
          Length = 1749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1317 RSENEGTS 1324
>NP_001229793
          Length = 331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>NP_001099037
          Length = 1757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1317 RSENEGTS 1324
>NP_001099036
          Length = 1770

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1330 RSENEGTS 1337
>NP_001273607
          Length = 228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>NP_001273606
          Length = 289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>NP_001273605
          Length = 301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>NP_071396
          Length = 1805

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1330 RSENEGTS 1337
>NP_996845
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>NP_001526
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>NP_001229795
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>XP_006724063
          Length = 228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>XP_006724062
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>XP_006724061
          Length = 301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>XP_005261168
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RSESQG 6
          RSESQG
Sbjct: 9  RSESQG 14
>XP_006722637
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SESQGTAS 9
           SES+GT S
Sbjct: 361 SESEGTKS 368
>XP_005266839
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SESQGTAS 9
           SES+GT S
Sbjct: 462 SESEGTKS 469
>XP_006721832
          Length = 1092

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SESQGTAS 9
           SES GT+S
Sbjct: 633 SESSGTSS 640
>XP_006715230
          Length = 1734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1259 RSENEGTS 1266
>XP_006715229
          Length = 1782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1307 RSENEGTS 1314
>XP_005249350
          Length = 1810

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1370 RSENEGTS 1377
>XP_005249349
          Length = 1824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1370 RSENEGTS 1377
>XP_005249348
          Length = 1832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1357 RSENEGTS 1364
>XP_005249347
          Length = 1837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1370 RSENEGTS 1377
>XP_005249346
          Length = 1845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RSESQGTA 8
            RSE++GT+
Sbjct: 1370 RSENEGTS 1377
>NP_954635
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQGTAS 9
           SQGTAS
Sbjct: 101 SQGTAS 106
>NP_000679
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQGTAS 9
           SQGTAS
Sbjct: 101 SQGTAS 106
>NP_001265204
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSESQGTAS 9
           RSE  GT+S
Sbjct: 215 RSEGVGTSS 223
>NP_937987
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSESQGTAS 9
           RSE  GT+S
Sbjct: 247 RSEGVGTSS 255
>NP_997705
          Length = 129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSESQGTAS 9
           RSE  GT+S
Sbjct: 95  RSEGVGTSS 103
>NP_001265205
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSESQGTAS 9
           RSE  GT+S
Sbjct: 172 RSEGVGTSS 180
>NP_001265206
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSESQGTAS 9
           RSE  GT+S
Sbjct: 172 RSEGVGTSS 180
>NP_001265207
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSESQGTAS 9
           RSE  GT+S
Sbjct: 172 RSEGVGTSS 180
>NP_001128119
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSESQGTAS 9
           +SE++GT S
Sbjct: 309 KSEAKGTVS 317
>NP_940997
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSESQGTAS 9
           +SE++GT S
Sbjct: 309 KSEAKGTVS 317
>XP_005248564
          Length = 2342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SESQGTAS 9
           SES+ TAS
Sbjct: 968 SESEATAS 975
>XP_006713973
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSESQGTAS 9
           +SE++GT S
Sbjct: 330 KSEAKGTVS 338
>XP_006713972
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSESQGTAS 9
           +SE++GT S
Sbjct: 330 KSEAKGTVS 338
>XP_006713971
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RSESQGTAS 9
           +SE++GT S
Sbjct: 330 KSEAKGTVS 338
>XP_005265002
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQGTAS 9
           SQGTAS
Sbjct: 101 SQGTAS 106
>XP_005265001
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SQGTAS 9
           SQGTAS
Sbjct: 118 SQGTAS 123
>XP_005246212
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSESQGTAS 9
           RSE  GT+S
Sbjct: 172 RSEGVGTSS 180
>XP_005246211
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RSESQGTAS 9
           RSE  GT+S
Sbjct: 172 RSEGVGTSS 180
>NP_005900
          Length = 2468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SESQGTAS 9
            SES+ TAS
Sbjct: 1094 SESEATAS 1101
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.278   0.0933    0.209 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 474,066
Number of extensions: 657
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.7 bits)
S2: 28 (15.4 bits)

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