Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     665
NP_653080                                                              19     665
XP_005267292                                                           19     665
XP_005267291                                                           19     665
XP_005267290                                                           19     665
NP_056023                                                              18    1935
NP_001190985                                                           18    1935
NP_001077094                                                           18    1935
XP_005258153                                                           18    1935
XP_005258152                                                           18    1935
XP_005258151                                                           18    1935
XP_005258150                                                           18    1935
XP_005258149                                                           18    1935
NP_001131140                                                           17    4312
NP_036247                                                              17    4312
NP_006725                                                              17    4312
NP_003892                                                              17    4312
NP_001131139                                                           17    4312
XP_006718116                                                           17    4312
XP_006718115                                                           17    4312
XP_005270320                                                           17    4312
XP_005267014                                                           17    4312
NP_072179                                                              16    7355
NP_002881                                                              16    7355
NP_001094089                                                           16    7355
NP_612384                                                              16    7355
NP_001243367                                                           16    7355
NP_001098998                                                           16    7355
NP_945346                                                              16    7355
NP_112492                                                              16    7355
NP_114102                                                              16    7355
XP_005259182                                                           16    7355
XP_006722639                                                           16    7355
XP_006722638                                                           16    7355
NP_001138764                                                           15    9605
NP_065681                                                              15    9605
NP_066124                                                              15    9605
NP_001164163                                                           15    9605
NP_000274                                                              15    9605
NP_001138763                                                           15    9605
NP_995586                                                              15    9605
NP_001164164                                                           15    9605
NP_061833                                                              15    9605
XP_006717999                                                           15    9605
XP_005272337                                                           15    9605
XP_005272336                                                           15    9605
>NP_005091
          Length = 1782

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SDISKDMS 9
            SDISKDMS
Sbjct: 1628 SDISKDMS 1635
>NP_653080
          Length = 1684

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SDISKDMS 9
            SDISKDMS
Sbjct: 1530 SDISKDMS 1537
>XP_005267292
          Length = 1677

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SDISKDMS 9
            SDISKDMS
Sbjct: 1523 SDISKDMS 1530
>XP_005267291
          Length = 1684

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SDISKDMS 9
            SDISKDMS
Sbjct: 1530 SDISKDMS 1537
>XP_005267290
          Length = 1782

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SDISKDMS 9
            SDISKDMS
Sbjct: 1628 SDISKDMS 1635
>NP_056023
          Length = 2062

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  RSDISKDM 8
          RSD+SK+M
Sbjct: 45 RSDVSKEM 52
>NP_001190985
          Length = 2039

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  RSDISKDM 8
          RSD+SK+M
Sbjct: 45 RSDVSKEM 52
>NP_001077094
          Length = 2039

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  RSDISKDM 8
          RSD+SK+M
Sbjct: 45 RSDVSKEM 52
>XP_005258153
          Length = 2037

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  RSDISKDM 8
          RSD+SK+M
Sbjct: 45 RSDVSKEM 52
>XP_005258152
          Length = 2060

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  RSDISKDM 8
          RSD+SK+M
Sbjct: 45 RSDVSKEM 52
>XP_005258151
          Length = 2062

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  RSDISKDM 8
          RSD+SK+M
Sbjct: 45 RSDVSKEM 52
>XP_005258150
          Length = 2062

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  RSDISKDM 8
          RSD+SK+M
Sbjct: 45 RSDVSKEM 52
>XP_005258149
          Length = 2062

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  RSDISKDM 8
          RSD+SK+M
Sbjct: 45 RSDVSKEM 52
>NP_001131140
          Length = 1982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RSDISKDM 8
           +SD+SKD+
Sbjct: 182 KSDVSKDV 189
>NP_036247
          Length = 1982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RSDISKDM 8
           +SD+SKD+
Sbjct: 182 KSDVSKDV 189
>NP_006725
          Length = 2446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SDISKDMS 9
            SDI KD+S
Sbjct: 1481 SDIKKDLS 1488
>NP_003892
          Length = 568

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RSDISKDMS 9
           + DISK+MS
Sbjct: 96  KDDISKNMS 104
>NP_001131139
          Length = 1982

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RSDISKDM 8
           +SD+SKD+
Sbjct: 182 KSDVSKDV 189
>XP_006718116
          Length = 488

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RSDISKDMS 9
          + DISK+MS
Sbjct: 16 KDDISKNMS 24
>XP_006718115
          Length = 567

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RSDISKDMS 9
           + DISK+MS
Sbjct: 95  KDDISKNMS 103
>XP_005270320
          Length = 568

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RSDISKDMS 9
           + DISK+MS
Sbjct: 96  KDDISKNMS 104
>XP_005267014
          Length = 2446

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    SDISKDMS 9
            SDI KD+S
Sbjct: 1481 SDIKKDLS 1488
>NP_072179
          Length = 870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RSDISKDMS 9
           R+D+S+D++
Sbjct: 811 RTDLSRDLA 819
>NP_002881
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RSDISKDMS 9
           R+D+S+D++
Sbjct: 988 RTDLSRDLA 996
>NP_001094089
          Length = 633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SDISKDMS 9
           SD+ KDM+
Sbjct: 492 SDLKKDMN 499
>NP_612384
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SDISKDMS 9
           SD+ KDM+
Sbjct: 227 SDLKKDMN 234
>NP_001243367
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SDISKDMS 9
           SD+ KDM+
Sbjct: 165 SDLKKDMN 172
>NP_001098998
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SDISKDMS 9
           SD++KD S
Sbjct: 433 SDVAKDFS 440
>NP_945346
          Length = 829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SDISKDMS 9
           SD++KD S
Sbjct: 433 SDVAKDFS 440
>NP_112492
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SDISKDMS 9
           SD+ KDM+
Sbjct: 338 SDLKKDMN 345
>NP_114102
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SDISKDMS 9
           SDIS D+S
Sbjct: 244 SDISSDVS 251
>XP_005259182
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SDISKDMS 9
           SDIS D+S
Sbjct: 244 SDISSDVS 251
>XP_006722639
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SDISKDMS 9
           SD+ KDM+
Sbjct: 224 SDLKKDMN 231
>XP_006722638
          Length = 607

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   SDISKDMS 9
           SD+ KDM+
Sbjct: 466 SDLKKDMN 473
>NP_001138764
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSDISKDM 8
           R DI++DM
Sbjct: 165 RKDIAQDM 172
>NP_065681
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    SDISKDM 8
            +DISKD+
Sbjct: 999  ADISKDL 1005
>NP_066124
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    SDISKDM 8
            +DISKD+
Sbjct: 999  ADISKDL 1005
>NP_001164163
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RSDISKD 7
           +SDI+KD
Sbjct: 577 KSDITKD 583
>NP_000274
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSDISKDM 8
           R DI++DM
Sbjct: 444 RKDIAQDM 451
>NP_001138763
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSDISKDM 8
           R DI++DM
Sbjct: 444 RKDIAQDM 451
>NP_995586
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RSDISKD 7
           +SDI+KD
Sbjct: 441 KSDITKD 447
>NP_001164164
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RSDISKD 7
           +SDI+KD
Sbjct: 577 KSDITKD 583
>NP_061833
          Length = 295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   RSDISKDMS 9
           +SD++KD++
Sbjct: 198 KSDLTKDVT 206
>XP_006717999
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    SDISKDM 8
            +DISKD+
Sbjct: 1092 ADISKDL 1098
>XP_005272337
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSDISKDM 8
           R DI++DM
Sbjct: 165 RKDIAQDM 172
>XP_005272336
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RSDISKDM 8
           R DI++DM
Sbjct: 165 RKDIAQDM 172
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.115    0.275 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 520,370
Number of extensions: 1025
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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