Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              19     869
NP_008958                                                              17    4312
NP_004044                                                              16    5631
NP_079255                                                              16    5631
NP_001036249                                                           16    5631
NP_001106203                                                           16    5631
XP_005268373                                                           16    5631
XP_005268372                                                           16    5631
XP_005268371                                                           16    5631
XP_006720031                                                           16    5631
XP_005268370                                                           16    5631
XP_006720030                                                           16    5631
XP_005268369                                                           16    5631
XP_006720029                                                           16    5631
XP_005268367                                                           16    5631
XP_005268366                                                           16    5631
XP_005268365                                                           16    5631
XP_005268364                                                           16    5631
XP_006714268                                                           16    5631
XP_005263031                                                           16    5631
XP_006714267                                                           16    5631
XP_006714266                                                           16    5631
XP_006714265                                                           16    5631
XP_006714264                                                           16    5631
XP_006714263                                                           16    5631
XP_006714262                                                           16    5631
NP_003310                                                              16    7355
NP_597676                                                              16    7355
NP_001243779                                                           16    7355
NP_596869                                                              16    7355
NP_149035                                                              16    7355
NP_001015056                                                           16    7355
NP_001015055                                                           16    7355
NP_000169                                                              16    7355
XP_005260463                                                           16    7355
XP_005246888                                                           16    7355
XP_006712788                                                           16    7355
XP_006712787                                                           16    7355
XP_006712786                                                           16    7355
XP_005264536                                                           16    7355
XP_005264535                                                           16    7355
NP_001254479                                                           16    7355
NP_597681                                                              16    7355
NP_001155048                                                           15    9605
NP_056404                                                              15    9605
NP_004251                                                              15    9605
NP_001155049                                                           15    9605
NP_004041                                                              15    9605
NP_001186768                                                           15    9605
NP_037496                                                              15    9605
NP_001269464                                                           15    9605
NP_694996                                                              15    9605
NP_006763                                                              15    9605
NP_653184                                                              15    9605
NP_001034451                                                           15    9605
NP_001265227                                                           15    9605
NP_001186793                                                           15    9605
NP_001191443                                                           15    9605
>NP_005179
          Length = 906

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           RRTLSDIS
Sbjct: 787 RRTLSDIS 794
>NP_008958
          Length = 1522

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RTLSDIS 8
           RTLSD+S
Sbjct: 309 RTLSDVS 315
>NP_004044
          Length = 437

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RRTLSDI 7
           RRTL+DI
Sbjct: 144 RRTLADI 150
>NP_079255
          Length = 1123

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 141 QRTLSDIA 148
>NP_001036249
          Length = 1113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RTLSDIST 9
           RT+SD++T
Sbjct: 496 RTISDLTT 503
>NP_001106203
          Length = 1125

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 143 QRTLSDIA 150
>XP_005268373
          Length = 984

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 141 QRTLSDIA 148
>XP_005268372
          Length = 1043

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 200 QRTLSDIA 207
>XP_005268371
          Length = 1067

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 147 QRTLSDIA 154
>XP_006720031
          Length = 1080

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  RRTLSDIS 8
          +RTLSDI+
Sbjct: 73 QRTLSDIA 80
>XP_005268370
          Length = 1112

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 105 QRTLSDIA 112
>XP_006720030
          Length = 1128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 121 QRTLSDIA 128
>XP_005268369
          Length = 1132

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 125 QRTLSDIA 132
>XP_006720029
          Length = 1150

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 143 QRTLSDIA 150
>XP_005268367
          Length = 1154

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 147 QRTLSDIA 154
>XP_005268366
          Length = 1180

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 173 QRTLSDIA 180
>XP_005268365
          Length = 1182

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 200 QRTLSDIA 207
>XP_005268364
          Length = 1207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           +RTLSDI+
Sbjct: 200 QRTLSDIA 207
>XP_006714268
          Length = 1078

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RTLSDIST 9
           RT+SD++T
Sbjct: 496 RTISDLTT 503
>XP_005263031
          Length = 1113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RTLSDIST 9
           RT+SD++T
Sbjct: 496 RTISDLTT 503
>XP_006714267
          Length = 1117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RTLSDIST 9
           RT+SD++T
Sbjct: 496 RTISDLTT 503
>XP_006714266
          Length = 1125

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RTLSDIST 9
           RT+SD++T
Sbjct: 496 RTISDLTT 503
>XP_006714265
          Length = 1129

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RTLSDIST 9
           RT+SD++T
Sbjct: 496 RTISDLTT 503
>XP_006714264
          Length = 1129

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RTLSDIST 9
           RT+SD++T
Sbjct: 496 RTISDLTT 503
>XP_006714263
          Length = 1129

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RTLSDIST 9
           RT+SD++T
Sbjct: 496 RTISDLTT 503
>XP_006714262
          Length = 1129

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RTLSDIST 9
           RT+SD++T
Sbjct: 496 RTISDLTT 503
>NP_003310
          Length = 26926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     RRTLSDIS 8
             RR+L DIS
Sbjct: 25587 RRSLGDIS 25594
>NP_597676
          Length = 27051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     RRTLSDIS 8
             RR+L DIS
Sbjct: 25712 RRSLGDIS 25719
>NP_001243779
          Length = 34350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     RRTLSDIS 8
             RR+L DIS
Sbjct: 33011 RRSLGDIS 33018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RTLSDIST 9
            + LSDIST
Sbjct: 8423 KKLSDIST 8430
>NP_596869
          Length = 33423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     RRTLSDIS 8
             RR+L DIS
Sbjct: 32084 RRSLGDIS 32091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RTLSDIST 9
            + LSDIST
Sbjct: 7496 KKLSDIST 7503
>NP_149035
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RTLSDIS 8
           RTL+DIS
Sbjct: 156 RTLTDIS 162
>NP_001015056
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RTLSDIS 8
           RTL+DIS
Sbjct: 119 RTLTDIS 125
>NP_001015055
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RTLSDIS 8
           RTL+DIS
Sbjct: 169 RTLTDIS 175
>NP_000169
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RRTLSDIS 8
           RRT  DIS
Sbjct: 236 RRTFEDIS 243
>XP_005260463
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RRTLSDIS 8
           RRT  DIS
Sbjct: 236 RRTFEDIS 243
>XP_005246888
          Length = 22663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     RRTLSDIS 8
             RR+L DIS
Sbjct: 21324 RRSLGDIS 21331
>XP_006712788
          Length = 24022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     RRTLSDIS 8
             RR+L DIS
Sbjct: 22683 RRSLGDIS 22690
>XP_006712787
          Length = 33978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     RRTLSDIS 8
             RR+L DIS
Sbjct: 32639 RRSLGDIS 32646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RTLSDIST 9
            + LSDIST
Sbjct: 8424 KKLSDIST 8431
>XP_006712786
          Length = 35484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     RRTLSDIS 8
             RR+L DIS
Sbjct: 34145 RRSLGDIS 34152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RTLSDIST 9
            + LSDIST
Sbjct: 8424 KKLSDIST 8431
>XP_005264536
          Length = 465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RTLSDIS 8
           RTL+DIS
Sbjct: 169 RTLTDIS 175
>XP_005264535
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RTLSDIS 8
           RTL+DIS
Sbjct: 169 RTLTDIS 175
>NP_001254479
          Length = 35991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     RRTLSDIS 8
             RR+L DIS
Sbjct: 34652 RRSLGDIS 34659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RTLSDIST 9
            + LSDIST
Sbjct: 8740 KKLSDIST 8747
>NP_597681
          Length = 27118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1     RRTLSDIS 8
             RR+L DIS
Sbjct: 25779 RRSLGDIS 25786
>NP_001155048
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRTLSDIS 8
           R+TL DIS
Sbjct: 470 RKTLLDIS 477
>NP_056404
          Length = 718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRTLSDIS 8
           R+TL DIS
Sbjct: 558 RKTLLDIS 565
>NP_004251
          Length = 1208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRTLSDIS 8
           RRT SD++
Sbjct: 646 RRTASDVA 653
>NP_001155049
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRTLSDIS 8
           R+TL DIS
Sbjct: 149 RKTLLDIS 156
>NP_004041
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RRTLSDIS 8
          RRT SD++
Sbjct: 58 RRTFSDLA 65
>NP_001186768
          Length = 193

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RRTLSDIS 8
          RRT SD++
Sbjct: 58 RRTFSDLA 65
>NP_037496
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           RRT+SD++
Sbjct: 114 RRTVSDMN 121
>NP_001269464
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RRTLSDIS 8
           RRT+SD++
Sbjct: 114 RRTVSDMN 121
>NP_694996
          Length = 2526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RTLSDIST 9
           RT+ D+ST
Sbjct: 190 RTIRDLST 197
>NP_006763
          Length = 1343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTLSDIST 9
           R L+DIST
Sbjct: 716 RLLNDIST 723
>NP_653184
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RTLSDI 7
           RTLSDI
Sbjct: 163 RTLSDI 168
>NP_001034451
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RTLSDI 7
           RTLSDI
Sbjct: 163 RTLSDI 168
>NP_001265227
          Length = 2614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RTLSDIST 9
           RT+ D+ST
Sbjct: 190 RTIRDLST 197
>NP_001186793
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RRTLSDIS 8
          RRT SD++
Sbjct: 58 RRTFSDLA 65
>NP_001191443
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RRTLSDIST 9
          RR+LSD  T
Sbjct: 10 RRSLSDSET 18
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.123    0.302 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 371,772
Number of extensions: 537
Number of successful extensions: 63
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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