Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              21     229
XP_006717990                                                           21     229
XP_006717989                                                           21     229
NP_954868                                                              19     869
NP_954869                                                              19     869
NP_001277153                                                           19     869
NP_954870                                                              19     869
NP_954863                                                              19     869
NP_570141                                                              19     869
NP_001135440                                                           19     869
NP_003791                                                              18    1935
NP_001273357                                                           18    1935
NP_001273355                                                           18    1935
XP_006715652                                                           18    1935
NP_694969                                                              17    2528
NP_003048                                                              17    3301
NP_001243839                                                           17    3301
NP_002010                                                              17    3301
NP_001153392                                                           17    3301
NP_001153503                                                           17    3301
NP_001153502                                                           17    3301
NP_004719                                                              17    3301
XP_005267162                                                           17    3301
XP_005267161                                                           17    3301
XP_005267160                                                           17    3301
XP_005267159                                                           17    3301
NP_001035822                                                           17    4312
NP_001035816                                                           17    4312
NP_001035818                                                           17    4312
NP_001035817                                                           17    4312
NP_001035819                                                           17    4312
NP_004407                                                              17    4312
XP_005270205                                                           17    4312
XP_005270372                                                           17    4312
XP_005277709                                                           17    4312
NP_076950                                                              17    4312
NP_003575                                                              16    5631
NP_009158                                                              16    5631
XP_005261530                                                           16    5631
XP_006724279                                                           16    5631
XP_006724278                                                           16    5631
XP_006724277                                                           16    5631
XP_006724274                                                           16    5631
XP_006724273                                                           16    5631
XP_005261528                                                           16    5631
XP_005261527                                                           16    5631
XP_005264661                                                           16    5631
NP_001157588                                                           16    7355
NP_065089                                                              16    7355
NP_001157586                                                           16    7355
NP_001157587                                                           16    7355
NP_001036189                                                           16    7355
NP_954634                                                              16    7355
XP_006723894                                                           16    7355
XP_006720089                                                           16    7355
NP_001135938                                                           16    7355
NP_597700                                                              16    7355
NP_689541                                                              16    7355
NP_001276989                                                           15    9605
NP_004627                                                              15    9605
NP_001276991                                                           15    9605
NP_001276990                                                           15    9605
NP_001276992                                                           15    9605
NP_001005914                                                           15    9605
NP_079488                                                              15    9605
NP_789787                                                              15    9605
NP_006036                                                              15    9605
NP_001008781                                                           15    9605
XP_006718827                                                           15    9605
XP_005253263                                                           15    9605
XP_006718205                                                           15    9605
XP_005268519                                                           15    9605
XP_006714849                                                           15    9605
XP_005268518                                                           15    9605
NP_057547                                                              15    9605
>NP_000305
          Length = 403

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   RTGVMICA 9
           RTGVMICA
Sbjct: 130 RTGVMICA 137
>XP_006717990
          Length = 175

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   RTGVMICA 9
           RTGVMICA
Sbjct: 115 RTGVMICA 122
>XP_006717989
          Length = 388

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   RTGVMICA 9
           RTGVMICA
Sbjct: 115 RTGVMICA 122
>NP_954868
          Length = 533

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTGVMICA 9
           RTG M+CA
Sbjct: 326 RTGTMVCA 333
>NP_954869
          Length = 513

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTGVMICA 9
           RTG M+CA
Sbjct: 306 RTGTMVCA 313
>NP_001277153
          Length = 413

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTGVMICA 9
           RTG M+CA
Sbjct: 206 RTGTMVCA 213
>NP_954870
          Length = 551

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTGVMICA 9
           RTG M+CA
Sbjct: 344 RTGTMVCA 351
>NP_954863
          Length = 522

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTGVMICA 9
           RTG M+CA
Sbjct: 326 RTGTMVCA 333
>NP_570141
          Length = 445

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTGVMICA 9
           RTG M+CA
Sbjct: 249 RTGTMVCA 256
>NP_001135440
          Length = 411

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTGVMICA 9
           RTG M+CA
Sbjct: 215 RTGTMVCA 222
>NP_003791
          Length = 597

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTGVMICA 9
           RTG +ICA
Sbjct: 132 RTGFLICA 139
>NP_001273357
          Length = 514

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RTGVMICA 9
          RTG +ICA
Sbjct: 72 RTGFLICA 79
>NP_001273355
          Length = 574

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTGVMICA 9
           RTG +ICA
Sbjct: 132 RTGFLICA 139
>XP_006715652
          Length = 574

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RTGVMICA 9
           RTG +ICA
Sbjct: 103 RTGFLICA 110
>NP_694969
          Length = 170

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RTGVMICA 9
          RTG+++CA
Sbjct: 4  RTGLILCA 11
>NP_003048
          Length = 554

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R  GVM+C+
Sbjct: 462 RNLGVMVCS 470
>NP_001243839
          Length = 715

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTGV IC
Sbjct: 465 RTGVCIC 471
>NP_002010
          Length = 1338

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TGVMICA 9
          TGV++CA
Sbjct: 7  TGVLLCA 13
>NP_001153392
          Length = 687

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TGVMICA 9
          TGV++CA
Sbjct: 7  TGVLLCA 13
>NP_001153503
          Length = 541

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TGVMICA 9
          TGV++CA
Sbjct: 7  TGVLLCA 13
>NP_001153502
          Length = 733

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TGVMICA 9
          TGV++CA
Sbjct: 7  TGVLLCA 13
>NP_004719
          Length = 783

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTGV IC
Sbjct: 533 RTGVCIC 539
>XP_005267162
          Length = 418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R  GVM+C+
Sbjct: 270 RNLGVMVCS 278
>XP_005267161
          Length = 418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R  GVM+C+
Sbjct: 270 RNLGVMVCS 278
>XP_005267160
          Length = 573

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R  GVM+C+
Sbjct: 462 RNLGVMVCS 470
>XP_005267159
          Length = 610

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R  GVM+C+
Sbjct: 462 RNLGVMVCS 470
>NP_001035822
          Length = 339

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTGV +C
Sbjct: 278 RTGVFLC 284
>NP_001035816
          Length = 420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTGV +C
Sbjct: 359 RTGVFLC 365
>NP_001035818
          Length = 269

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTGV +C
Sbjct: 208 RTGVFLC 214
>NP_001035817
          Length = 411

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTGV +C
Sbjct: 350 RTGVFLC 356
>NP_001035819
          Length = 228

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTGV +C
Sbjct: 167 RTGVFLC 173
>NP_004407
          Length = 620

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TGVMICA 9
           TG+++CA
Sbjct: 337 TGILLCA 343
>XP_005270205
          Length = 672

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTG+ IC
Sbjct: 419 RTGICIC 425
>XP_005270372
          Length = 339

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTGV +C
Sbjct: 278 RTGVFLC 284
>XP_005277709
          Length = 339

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTGV +C
Sbjct: 278 RTGVFLC 284
>NP_076950
          Length = 737

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTG+ IC
Sbjct: 484 RTGICIC 490
>NP_003575
          Length = 377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTG +IC
Sbjct: 205 RTGYLIC 211
>NP_009158
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   GVMICA 9
           GVM+CA
Sbjct: 209 GVMLCA 214
>XP_005261530
          Length = 784

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           RRT V+ C
Sbjct: 474 RRTSVLFC 481
>XP_006724279
          Length = 802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           RRT V+ C
Sbjct: 492 RRTSVLFC 499
>XP_006724278
          Length = 978

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           RRT V+ C
Sbjct: 916 RRTSVLFC 923
>XP_006724277
          Length = 995

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           RRT V+ C
Sbjct: 916 RRTSVLFC 923
>XP_006724274
          Length = 1189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           RRT V+ C
Sbjct: 879 RRTSVLFC 886
>XP_006724273
          Length = 1189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           RRT V+ C
Sbjct: 879 RRTSVLFC 886
>XP_005261528
          Length = 1189

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           RRT V+ C
Sbjct: 879 RRTSVLFC 886
>XP_005261527
          Length = 1226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           RRT V+ C
Sbjct: 916 RRTSVLFC 923
>XP_005264661
          Length = 273

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTG +IC
Sbjct: 205 RTGYLIC 211
>NP_001157588
          Length = 786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  TGVMICA 9
          TG+M CA
Sbjct: 4  TGIMDCA 10
>NP_065089
          Length = 786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  TGVMICA 9
          TG+M CA
Sbjct: 4  TGIMDCA 10
>NP_001157586
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  TGVMICA 9
          TG+M CA
Sbjct: 4  TGIMDCA 10
>NP_001157587
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  TGVMICA 9
          TG+M CA
Sbjct: 4  TGIMDCA 10
>NP_001036189
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   TGVMIC 8
           TG++IC
Sbjct: 377 TGILIC 382
>NP_954634
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTG+ IC
Sbjct: 220 RTGLRIC 226
>XP_006723894
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  TGVMICA 9
          TG+M CA
Sbjct: 4  TGIMDCA 10
>XP_006720089
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTG+ IC
Sbjct: 178 RTGLRIC 184
>NP_001135938
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RTGVMI 7
           RTGVMI
Sbjct: 106 RTGVMI 111
>NP_597700
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RTGVMI 7
           RTGVMI
Sbjct: 206 RTGVMI 211
>NP_689541
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           RTG+ IC
Sbjct: 177 RTGLRIC 183
>NP_001276989
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R +GV +CA
Sbjct: 637 RDSGVYLCA 645
>NP_004627
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R +GV +CA
Sbjct: 637 RDSGVYLCA 645
>NP_001276991
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R +GV +CA
Sbjct: 294 RDSGVYLCA 302
>NP_001276990
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R +GV +CA
Sbjct: 642 RDSGVYLCA 650
>NP_001276992
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R +GV +CA
Sbjct: 294 RDSGVYLCA 302
>NP_001005914
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRTGVMICA 9
           R +GV +CA
Sbjct: 636 RDSGVYLCA 644
>NP_079488
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           R+TG  IC
Sbjct: 329 RKTGHQIC 336
>NP_789787
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   RTGVMIC 8
           + GVM+C
Sbjct: 276 KIGVMVC 282
>NP_006036
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   RTGVMICA 9
           RTG + CA
Sbjct: 775 RTGKLTCA 782
>NP_001008781
          Length = 4557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    RTGVMICA 9
            R GV++C+
Sbjct: 4277 RRGVVVCS 4284
>XP_006718827
          Length = 3479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    RTGVMICA 9
            R GV++C+
Sbjct: 3167 RRGVVVCS 3174
>XP_005253263
          Length = 1231

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/6 (50%), Positives = 6/6 (100%)

Query: 3    TGVMIC 8
            TG+++C
Sbjct: 1206 TGILVC 1211
>XP_006718205
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  RRTGVMIC 8
          R TGV +C
Sbjct: 13 RTTGVGVC 20
>XP_005268519
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           R+TG  IC
Sbjct: 284 RKTGHQIC 291
>XP_006714849
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           R+TG  IC
Sbjct: 284 RKTGHQIC 291
>XP_005268518
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           R+TG  IC
Sbjct: 284 RKTGHQIC 291
>NP_057547
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   RRTGVMIC 8
           R+TG  IC
Sbjct: 284 RKTGHQIC 291
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.344    0.143    0.476 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 578,958
Number of extensions: 963
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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