Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              22     134
NP_001034568                                                           17    3301
XP_005268301                                                           17    3301
XP_006720407                                                           17    3301
NP_000811                                                              17    4312
NP_001267474                                                           16    5631
NP_060732                                                              16    5631
NP_443715                                                              16    5631
NP_443716                                                              16    5631
NP_001267470                                                           16    5631
NP_443711                                                              16    5631
NP_001267475                                                           16    5631
NP_001158268                                                           16    5631
NP_064506                                                              16    5631
NP_775742                                                              16    5631
NP_056039                                                              16    5631
XP_006713757                                                           16    5631
XP_006713756                                                           16    5631
XP_005247668                                                           16    5631
XP_006713755                                                           16    5631
XP_005247667                                                           16    5631
XP_005247666                                                           16    5631
XP_005247665                                                           16    5631
XP_005247664                                                           16    5631
XP_006713754                                                           16    5631
XP_006713753                                                           16    5631
XP_005247661                                                           16    5631
XP_006713752                                                           16    5631
XP_005247660                                                           16    5631
XP_006713141                                                           16    5631
XP_006713140                                                           16    5631
XP_005265056                                                           16    5631
XP_006713021                                                           16    5631
XP_006713020                                                           16    5631
XP_006713019                                                           16    5631
NP_031392                                                              16    7355
NP_001007268                                                           16    7355
NP_001182570                                                           16    7355
NP_001269695                                                           16    7355
NP_001098714                                                           16    7355
XP_006722401                                                           16    7355
XP_006722400                                                           16    7355
XP_006722399                                                           16    7355
XP_006722398                                                           16    7355
XP_005246450                                                           16    7355
XP_005246449                                                           16    7355
XP_005264288                                                           16    7355
NP_002836                                                              16    7355
NP_001274152                                                           15    9605
NP_001158213                                                           15    9605
NP_001657                                                              15    9605
NP_997320                                                              15    9605
NP_689783                                                              15    9605
NP_001245211                                                           15    9605
NP_056288                                                              15    9605
NP_689716                                                              15    9605
NP_054858                                                              15    9605
NP_998797                                                              15    9605
NP_998796                                                              15    9605
XP_005253612                                                           15    9605
XP_005251429                                                           15    9605
NP_001005234                                                           15    9605
>NP_004251
          Length = 1208

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRTFQVFHS 9
            RRTFQ FHS
Sbjct: 1071 RRTFQAFHS 1079
>NP_001034568
          Length = 823

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RRTFQVF 7
           R+TFQVF
Sbjct: 238 RQTFQVF 244
>XP_005268301
          Length = 662

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RRTFQVF 7
          R+TFQVF
Sbjct: 77 RQTFQVF 83
>XP_006720407
          Length = 813

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RRTFQVF 7
           R+TFQVF
Sbjct: 228 RQTFQVF 234
>NP_000811
          Length = 678

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  RRTFQVF 7
          RR FQVF
Sbjct: 47 RRAFQVF 53
>NP_001267474
          Length = 1091

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1061 FQMFHS 1066
>NP_060732
          Length = 1182

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1152 FQMFHS 1157
>NP_443715
          Length = 1241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1211 FQMFHS 1216
>NP_443716
          Length = 1131

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1101 FQMFHS 1106
>NP_001267470
          Length = 1234

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1204 FQMFHS 1209
>NP_443711
          Length = 1292

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1262 FQMFHS 1267
>NP_001267475
          Length = 1032

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1002 FQMFHS 1007
>NP_001158268
          Length = 186

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RTFQVF 7
          RTFQ+F
Sbjct: 35 RTFQIF 40
>NP_064506
          Length = 1516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   RTFQVFH 8
           RTF  FH
Sbjct: 193 RTFSAFH 199
>NP_775742
          Length = 274

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RTFQVF 7
           RTFQ+F
Sbjct: 123 RTFQIF 128
>NP_056039
          Length = 1233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQV+HS
Sbjct: 1158 FQVYHS 1163
>XP_006713757
          Length = 1034

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1004 FQMFHS 1009
>XP_006713756
          Length = 1093

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1063 FQMFHS 1068
>XP_005247668
          Length = 1132

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1102 FQMFHS 1107
>XP_006713755
          Length = 1165

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1135 FQMFHS 1140
>XP_005247667
          Length = 1183

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1153 FQMFHS 1158
>XP_005247666
          Length = 1183

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1153 FQMFHS 1158
>XP_005247665
          Length = 1184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1154 FQMFHS 1159
>XP_005247664
          Length = 1191

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1161 FQMFHS 1166
>XP_006713754
          Length = 1224

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1194 FQMFHS 1199
>XP_006713753
          Length = 1225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1195 FQMFHS 1200
>XP_005247661
          Length = 1242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1212 FQMFHS 1217
>XP_006713752
          Length = 1242

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1212 FQMFHS 1217
>XP_005247660
          Length = 1243

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQ+FHS
Sbjct: 1213 FQMFHS 1218
>XP_006713141
          Length = 1274

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQV+HS
Sbjct: 1199 FQVYHS 1204
>XP_006713140
          Length = 1629

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQV+HS
Sbjct: 1554 FQVYHS 1559
>XP_005265056
          Length = 1670

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    FQVFHS 9
            FQV+HS
Sbjct: 1595 FQVYHS 1600
>XP_006713021
          Length = 161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RTFQVF 7
           RTFQ+F
Sbjct: 123 RTFQIF 128
>XP_006713020
          Length = 174

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RTFQVF 7
           RTFQ+F
Sbjct: 123 RTFQIF 128
>XP_006713019
          Length = 259

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RTFQVF 7
           RTFQ+F
Sbjct: 123 RTFQIF 128
>NP_031392
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FQVFHS 9
           F+VFHS
Sbjct: 678 FKVFHS 683
>NP_001007268
          Length = 1324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FQVFHS 9
           F+VFHS
Sbjct: 678 FKVFHS 683
>NP_001182570
          Length = 1461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FQVFHS 9
           F+VFHS
Sbjct: 678 FKVFHS 683
>NP_001269695
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4  FQVFH 8
          FQVFH
Sbjct: 12 FQVFH 16
>NP_001098714
          Length = 1465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRTFQVFHS 9
            +RT  VFH+
Sbjct: 1425 QRTVDVFHA 1433
>XP_006722401
          Length = 1432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRTFQVFHS 9
            +RT  VFH+
Sbjct: 1392 QRTVDVFHA 1400
>XP_006722400
          Length = 1469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRTFQVFHS 9
            +RT  VFH+
Sbjct: 1429 QRTVDVFHA 1437
>XP_006722399
          Length = 1477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRTFQVFHS 9
            +RT  VFH+
Sbjct: 1437 QRTVDVFHA 1445
>XP_006722398
          Length = 1494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRTFQVFHS 9
            +RT  VFH+
Sbjct: 1454 QRTVDVFHA 1462
>XP_005246450
          Length = 1461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FQVFHS 9
           F+VFHS
Sbjct: 678 FKVFHS 683
>XP_005246449
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   FQVFHS 9
           F+VFHS
Sbjct: 678 FKVFHS 683
>XP_005264288
          Length = 205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRTFQVFHS 9
           R+T  VFHS
Sbjct: 168 RQTETVFHS 176
>NP_002836
          Length = 1452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRTFQVFHS 9
            +RT  VFH+
Sbjct: 1412 QRTVDVFHA 1420
>NP_001274152
          Length = 1791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RTFQVFHS 9
           RTF+VF +
Sbjct: 222 RTFRVFRA 229
>NP_001158213
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 1   RRTFQVFH 8
           ++T+Q +H
Sbjct: 168 KKTYQAYH 175
>NP_001657
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/8 (37%), Positives = 7/8 (87%)

Query: 1   RRTFQVFH 8
           ++T+Q +H
Sbjct: 168 KKTYQAYH 175
>NP_997320
          Length = 4471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    TFQVFH 8
            TFQ FH
Sbjct: 4117 TFQPFH 4122
>NP_689783
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RTFQVFHS 9
           R+F+ FHS
Sbjct: 391 RSFKDFHS 398
>NP_001245211
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RTFQVFHS 9
           R+F+ FHS
Sbjct: 391 RSFKDFHS 398
>NP_056288
          Length = 2046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    RTFQVFHS 9
            +T+Q+ HS
Sbjct: 1877 KTYQLLHS 1884
>NP_689716
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RRTFQVF 7
           R+TFQ F
Sbjct: 305 RQTFQAF 311
>NP_054858
          Length = 1791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RTFQVFHS 9
           RTF+VF +
Sbjct: 222 RTFRVFRA 229
>NP_998797
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RRTFQVF 7
           R+TFQ F
Sbjct: 305 RQTFQAF 311
>NP_998796
          Length = 608

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RRTFQVF 7
           R+TFQ F
Sbjct: 305 RQTFQAF 311
>XP_005253612
          Length = 4589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    TFQVFH 8
            TFQ FH
Sbjct: 4235 TFQPFH 4240
>XP_005251429
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RTFQVFHS 9
           R+F+ FHS
Sbjct: 391 RSFKDFHS 398
>NP_001005234
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   TFQVFHS 9
           TF  FHS
Sbjct: 150 TFSYFHS 156
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.348    0.141    0.450 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 492,349
Number of extensions: 753
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.9 bits)
S2: 28 (15.4 bits)

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