Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              20     390
XP_006716142                                                           20     390
XP_005250088                                                           20     390
XP_006716141                                                           20     390
XP_005250085                                                           20     390
XP_006716140                                                           20     390
XP_005250084                                                           20     390
XP_005250083                                                           20     390
XP_005250082                                                           20     390
NP_001184033                                                           17    4312
NP_005924                                                              17    4312
NP_037407                                                              17    4312
NP_001243112                                                           17    4312
NP_001243111                                                           17    4312
XP_006721247                                                           17    4312
XP_006721246                                                           17    4312
XP_006721245                                                           17    4312
XP_006721244                                                           17    4312
XP_006718903                                                           17    4312
XP_006718902                                                           17    4312
XP_005251808                                                           16    5631
NP_001177408                                                           16    5631
NP_619639                                                              16    7355
NP_733842                                                              16    7355
NP_002470                                                              16    7355
NP_976221                                                              16    7355
NP_005327                                                              16    7355
NP_689413                                                              16    7355
NP_055241                                                              16    7355
XP_006712539                                                           16    7355
XP_005247059                                                           16    7355
XP_005247058                                                           16    7355
XP_006712538                                                           16    7355
XP_005247060                                                           16    7355
XP_005247057                                                           16    7355
NP_001258931                                                           15    9605
NP_212132                                                              15    9605
NP_001258929                                                           15    9605
NP_001258930                                                           15    9605
NP_001258928                                                           15    9605
NP_002244                                                              15    9605
NP_079194                                                              15    9605
NP_001138790                                                           15    9605
NP_001138788                                                           15    9605
NP_061944                                                              15    9605
NP_001157101                                                           15    9605
NP_001138789                                                           15    9605
NP_001138787                                                           15    9605
XP_006723939                                                           15    9605
XP_005260616                                                           15    9605
XP_005260615                                                           15    9605
XP_005255351                                                           15    9605
XP_005271350                                                           15    9605
XP_005271349                                                           15    9605
NP_689764                                                              15    9605
NP_079339                                                              15    9605
>NP_733751
          Length = 4911

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSVSVDIP 9
            RRSVSVD+P
Sbjct: 2515 RRSVSVDMP 2523
>XP_006716142
          Length = 4927

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSVSVDIP 9
            RRSVSVD+P
Sbjct: 2532 RRSVSVDMP 2540
>XP_005250088
          Length = 4928

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSVSVDIP 9
            RRSVSVD+P
Sbjct: 2532 RRSVSVDMP 2540
>XP_006716141
          Length = 4959

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSVSVDIP 9
            RRSVSVD+P
Sbjct: 2532 RRSVSVDMP 2540
>XP_005250085
          Length = 4979

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSVSVDIP 9
            RRSVSVD+P
Sbjct: 2532 RRSVSVDMP 2540
>XP_006716140
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSVSVDIP 9
            RRSVSVD+P
Sbjct: 2532 RRSVSVDMP 2540
>XP_005250084
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSVSVDIP 9
            RRSVSVD+P
Sbjct: 2532 RRSVSVDMP 2540
>XP_005250083
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSVSVDIP 9
            RRSVSVD+P
Sbjct: 2531 RRSVSVDMP 2539
>XP_005250082
          Length = 4983

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSVSVDIP 9
            RRSVSVD+P
Sbjct: 2532 RRSVSVDMP 2540
>NP_001184033
          Length = 3972

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    RRSVSVDIP 9
            RR+ S+D+P
Sbjct: 3810 RRATSMDLP 3818
>NP_005924
          Length = 3969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    RRSVSVDIP 9
            RR+ S+D+P
Sbjct: 3807 RRATSMDLP 3815
>NP_037407
          Length = 2663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    RSVSVDI 8
            RSVSVDI
Sbjct: 1789 RSVSVDI 1795
>NP_001243112
          Length = 2663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    RSVSVDI 8
            RSVSVDI
Sbjct: 1789 RSVSVDI 1795
>NP_001243111
          Length = 2663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    RSVSVDI 8
            RSVSVDI
Sbjct: 1789 RSVSVDI 1795
>XP_006721247
          Length = 2564

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    RSVSVDI 8
            RSVSVDI
Sbjct: 1690 RSVSVDI 1696
>XP_006721246
          Length = 2620

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    RSVSVDI 8
            RSVSVDI
Sbjct: 1746 RSVSVDI 1752
>XP_006721245
          Length = 2629

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    RSVSVDI 8
            RSVSVDI
Sbjct: 1755 RSVSVDI 1761
>XP_006721244
          Length = 2629

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    RSVSVDI 8
            RSVSVDI
Sbjct: 1755 RSVSVDI 1761
>XP_006718903
          Length = 2673

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    RRSVSVDIP 9
            RR+ S+D+P
Sbjct: 2511 RRATSMDLP 2519
>XP_006718902
          Length = 2964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    RRSVSVDIP 9
            RR+ S+D+P
Sbjct: 2802 RRATSMDLP 2810
>XP_005251808
          Length = 3075

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RRSVSVDI 8
            +RSVS+D+
Sbjct: 3062 KRSVSIDL 3069
>NP_001177408
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           RRS + DIP
Sbjct: 329 RRSTAPDIP 337
>NP_619639
          Length = 4074

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RRSVSVDI 8
            RRSV VD+
Sbjct: 1418 RRSVRVDL 1425
>NP_733842
          Length = 3396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RRSVSVDI 8
            RRSV VD+
Sbjct: 1418 RRSVRVDL 1425
>NP_002470
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  RRSVSVD 7
          R+SVSVD
Sbjct: 75 RKSVSVD 81
>NP_976221
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           R  VSV+IP
Sbjct: 324 RTGVSVEIP 332
>NP_005327
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           R  VSV+IP
Sbjct: 324 RTGVSVEIP 332
>NP_689413
          Length = 404

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  RSVSVDI 8
          RSVSVD+
Sbjct: 19 RSVSVDL 25
>NP_055241
          Length = 404

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  RSVSVDI 8
          RSVSVD+
Sbjct: 19 RSVSVDL 25
>XP_006712539
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           R  VSV+IP
Sbjct: 324 RTGVSVEIP 332
>XP_005247059
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           R  VSV+IP
Sbjct: 324 RTGVSVEIP 332
>XP_005247058
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           R  VSV+IP
Sbjct: 324 RTGVSVEIP 332
>XP_006712538
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           R  VSV+IP
Sbjct: 324 RTGVSVEIP 332
>XP_005247060
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           R  VSV+IP
Sbjct: 324 RTGVSVEIP 332
>XP_005247057
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           R  VSV+IP
Sbjct: 324 RTGVSVEIP 332
>NP_001258931
          Length = 632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRSVSVD 7
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_212132
          Length = 2109

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRSVSVD 7
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_001258929
          Length = 2100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRSVSVD 7
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_001258930
          Length = 2098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRSVSVD 7
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_001258928
          Length = 2129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRSVSVD 7
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_002244
          Length = 1356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  SVSVDIP 9
          SVS+D+P
Sbjct: 26 SVSLDLP 32
>NP_079194
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RSVSVDI 8
           RS+SVD+
Sbjct: 122 RSISVDL 128
>NP_001138790
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RSVSVDI 8
           RS+SVD+
Sbjct: 106 RSISVDL 112
>NP_001138788
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RSVSVDI 8
           RS+SVD+
Sbjct: 122 RSISVDL 128
>NP_061944
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           RRS+ +D P
Sbjct: 121 RRSLELDTP 129
>NP_001157101
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           R+ +SVD P
Sbjct: 158 RKYISVDAP 166
>NP_001138789
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RSVSVDI 8
          RS+SVD+
Sbjct: 15 RSISVDL 21
>NP_001138787
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RSVSVDI 8
           RS+SVD+
Sbjct: 122 RSISVDL 128
>XP_006723939
          Length = 249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RSVSVDI 8
          RS+SVD+
Sbjct: 15 RSISVDL 21
>XP_005260616
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RSVSVDI 8
           RS+SVD+
Sbjct: 100 RSISVDL 106
>XP_005260615
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RSVSVDI 8
           RS+SVD+
Sbjct: 207 RSISVDL 213
>XP_005255351
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RRSVSVDIP 9
           R  VSVD P
Sbjct: 334 RTGVSVDTP 342
>XP_005271350
          Length = 1854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRSVSVD 7
           RRS+S+D
Sbjct: 178 RRSMSID 184
>XP_005271349
          Length = 2131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRSVSVD 7
           RRS+S+D
Sbjct: 178 RRSMSID 184
>NP_689764
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RRSVSVD 7
           RRS SVD
Sbjct: 273 RRSASVD 279
>NP_079339
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRSVSVDIP 9
           R+ +SVD P
Sbjct: 158 RKYISVDAP 166
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.135    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 413,872
Number of extensions: 792
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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