Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     390
XP_006718908                                                           20     390
XP_005271621                                                           20     390
XP_006718907                                                           20     390
XP_006718906                                                           20     390
XP_005271619                                                           20     390
XP_005271618                                                           20     390
NP_001017423                                                           17    2528
NP_002851                                                              17    2528
XP_006717996                                                           17    2528
NP_004760                                                              17    4312
NP_064717                                                              17    4312
NP_064718                                                              17    4312
NP_001268916                                                           16    5631
NP_653170                                                              16    5631
XP_006711092                                                           16    5631
XP_006711091                                                           16    5631
NP_001933                                                              15    9605
NP_055872                                                              15    9605
NP_036419                                                              15    9605
NP_068761                                                              15    9605
NP_055464                                                              15    9605
NP_003137                                                              15    9605
NP_951008                                                              15    9605
XP_005259745                                                           15    9605
XP_006719852                                                           15    9605
XP_005266357                                                           15    9605
XP_006719851                                                           15    9605
XP_006719850                                                           15    9605
XP_006719849                                                           15    9605
XP_006719848                                                           15    9605
XP_005266356                                                           15    9605
XP_006719847                                                           15    9605
XP_006719846                                                           15    9605
XP_006719845                                                           15    9605
XP_006719844                                                           15    9605
XP_006719843                                                           15    9605
XP_006719842                                                           15    9605
XP_005274251                                                           15    9605
XP_006713621                                                           15    9605
XP_006713620                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSRITKNM 9
            RRSRITKN+
Sbjct: 2579 RRSRITKNV 2587
>XP_006718908
          Length = 1708

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSRITKNM 9
            RRSRITKN+
Sbjct: 1231 RRSRITKNV 1239
>XP_005271621
          Length = 2708

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSRITKNM 9
            RRSRITKN+
Sbjct: 2231 RRSRITKNV 2239
>XP_006718907
          Length = 3050

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSRITKNM 9
            RRSRITKN+
Sbjct: 2573 RRSRITKNV 2581
>XP_006718906
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSRITKNM 9
            RRSRITKN+
Sbjct: 2579 RRSRITKNV 2587
>XP_005271619
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSRITKNM 9
            RRSRITKN+
Sbjct: 2579 RRSRITKNV 2587
>XP_005271618
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RRSRITKNM 9
            RRSRITKN+
Sbjct: 2579 RRSRITKNV 2587
>NP_001017423
          Length = 793

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRSRITKNM 9
           RR+RI KN+
Sbjct: 454 RRTRIAKNL 462
>NP_002851
          Length = 795

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRSRITKNM 9
           RR+RI KN+
Sbjct: 456 RRTRIAKNL 464
>XP_006717996
          Length = 795

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRSRITKNM 9
           RR+RI KN+
Sbjct: 456 RRTRIAKNL 464
>NP_004760
          Length = 531

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRSRITKN 8
           RRSR+T N
Sbjct: 98  RRSRLTPN 105
>NP_064717
          Length = 549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRSRITKN 8
           RRSR+T N
Sbjct: 98  RRSRLTPN 105
>NP_064718
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRSRITKN 8
           RRSR+T N
Sbjct: 98  RRSRLTPN 105
>NP_001268916
          Length = 1203

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRSRITKNM 9
           RRS+ TKN+
Sbjct: 417 RRSKGTKNL 425
>NP_653170
          Length = 1216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRSRITKNM 9
           RRS+ TKN+
Sbjct: 417 RRSKGTKNL 425
>XP_006711092
          Length = 1161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRSRITKNM 9
           RRS+ TKN+
Sbjct: 417 RRSKGTKNL 425
>XP_006711091
          Length = 1161

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRSRITKNM 9
           RRS+ TKN+
Sbjct: 417 RRSKGTKNL 425
>NP_001933
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    RSRITK 7
            RSRITK
Sbjct: 1036 RSRITK 1041
>NP_055872
          Length = 4678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4192 SRVTKN 4197
>NP_036419
          Length = 778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSRITKNM 9
           RRS I K+M
Sbjct: 184 RRSEILKSM 192
>NP_068761
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSRITKNM 9
           ++SRI KN+
Sbjct: 530 QKSRIEKNL 538
>NP_055464
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RSRITKN 8
           RSR+TK+
Sbjct: 557 RSRVTKS 563
>NP_003137
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RITKNM 9
           R+TKNM
Sbjct: 301 RLTKNM 306
>NP_951008
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRSRITKNM 9
           ++SRI KN+
Sbjct: 530 QKSRIEKNL 538
>XP_005259745
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RSRITKN 8
           RSR+TK+
Sbjct: 103 RSRVTKS 109
>XP_006719852
          Length = 4752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4266 SRVTKN 4271
>XP_005266357
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4114 SRVTKN 4119
>XP_006719851
          Length = 4689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4203 SRVTKN 4208
>XP_006719850
          Length = 4697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4211 SRVTKN 4216
>XP_006719849
          Length = 4703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4217 SRVTKN 4222
>XP_006719848
          Length = 4737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4251 SRVTKN 4256
>XP_005266356
          Length = 4755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4269 SRVTKN 4274
>XP_006719847
          Length = 4761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4275 SRVTKN 4280
>XP_006719846
          Length = 4763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4277 SRVTKN 4282
>XP_006719845
          Length = 4772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4286 SRVTKN 4291
>XP_006719844
          Length = 4789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4303 SRVTKN 4308
>XP_006719843
          Length = 4794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4308 SRVTKN 4313
>XP_006719842
          Length = 4797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    SRITKN 8
            SR+TKN
Sbjct: 4311 SRVTKN 4316
>XP_005274251
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RITKNM 9
           R+TKNM
Sbjct: 301 RLTKNM 306
>XP_006713621
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSRITKNM 9
           RRS I K+M
Sbjct: 184 RRSEILKSM 192
>XP_006713620
          Length = 785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRSRITKNM 9
           RRS I K+M
Sbjct: 184 RRSEILKSM 192
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.127    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 375,302
Number of extensions: 622
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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