Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           19     665
NP_060785                                                              19     665
NP_361014                                                              19     665
NP_001258867                                                           18    1135
NP_001401                                                              18    1135
NP_149043                                                              17    2528
NP_001008781                                                           17    3301
XP_006718827                                                           17    3301
NP_000485                                                              16    5631
NP_065772                                                              16    7355
XP_006724837                                                           16    7355
NP_005017                                                              15    9605
NP_055608                                                              15    9605
NP_001136026                                                           15    9605
NP_001129507                                                           15    9605
NP_060192                                                              15    9605
XP_006726615                                                           15    9605
XP_006722857                                                           15    9605
XP_006722856                                                           15    9605
XP_005260040                                                           15    9605
XP_006720062                                                           15    9605
XP_006720061                                                           15    9605
XP_006720060                                                           15    9605
XP_006719085                                                           15    9605
XP_006719084                                                           15    9605
XP_006719083                                                           15    9605
XP_005251896                                                           15    9605
XP_005251895                                                           15    9605
XP_005251894                                                           15    9605
XP_006710753                                                           15    9605
XP_005263530                                                           15    9605
XP_006710752                                                           15    9605
XP_006710751                                                           15    9605
XP_006710750                                                           15    9605
XP_006710749                                                           15    9605
XP_006710038                                                           15    9605
XP_006710037                                                           15    9605
XP_006710036                                                           15    9605
NP_001138430                                                           15    9605
NP_055925                                                              15    9605
>NP_001013433
          Length = 589

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRRIISVQP 9
           RRRI SVQP
Sbjct: 104 RRRITSVQP 112
>NP_060785
          Length = 627

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRRIISVQP 9
           RRRI SVQP
Sbjct: 142 RRRITSVQP 150
>NP_361014
          Length = 707

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRRIISVQP 9
           RRRI SVQP
Sbjct: 222 RRRITSVQP 230
>NP_001258867
          Length = 2845

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    RRIISVQP 9
            RRI+SVQP
Sbjct: 2023 RRILSVQP 2030
>NP_001401
          Length = 2778

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    RRIISVQP 9
            RRI+SVQP
Sbjct: 1956 RRILSVQP 1963
>NP_149043
          Length = 1018

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   RRIISVQP 9
           RR+ISV+P
Sbjct: 988 RRLISVEP 995
>NP_001008781
          Length = 4557

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RIISVQP 9
            RIIS+QP
Sbjct: 3686 RIISIQP 3692
>XP_006718827
          Length = 3479

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    RIISVQP 9
            RIIS+QP
Sbjct: 2576 RIISIQP 2582
>NP_000485
          Length = 1497

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RRRIISVQP 9
            RRR I+V+P
Sbjct: 1489 RRRSIAVKP 1497
>NP_065772
          Length = 1709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RIISVQP 9
            R+ISV+P
Sbjct: 1010 RVISVEP 1016
>XP_006724837
          Length = 1533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIISVQP 9
           R+ISV+P
Sbjct: 834 RVISVEP 840
>NP_005017
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          +RR+  VQP
Sbjct: 86 QRRLCDVQP 94
>NP_055608
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   RRRIISVQP 9
           RRR+ +++P
Sbjct: 284 RRRVENIEP 292
>NP_001136026
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIISVQP 9
           RI+SV+P
Sbjct: 492 RILSVEP 498
>NP_001129507
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIISVQP 9
           RI+SV+P
Sbjct: 521 RILSVEP 527
>NP_060192
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIISVQP 9
           RI+SV+P
Sbjct: 521 RILSVEP 527
>XP_006726615
          Length = 163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          RR++ S QP
Sbjct: 28 RRKVQSAQP 36
>XP_006722857
          Length = 398

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIISVQP 9
           RI+SV+P
Sbjct: 260 RILSVEP 266
>XP_006722856
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIISVQP 9
           RI+SV+P
Sbjct: 307 RILSVEP 313
>XP_005260040
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIISVQP 9
           RI+SV+P
Sbjct: 492 RILSVEP 498
>XP_006720062
          Length = 163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          RR++ S QP
Sbjct: 28 RRKVQSAQP 36
>XP_006720061
          Length = 165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          RR++ S QP
Sbjct: 28 RRKVQSAQP 36
>XP_006720060
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          RR++ S QP
Sbjct: 28 RRKVQSAQP 36
>XP_006719085
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRIISVQ 8
           RRIISV+
Sbjct: 419 RRIISVE 425
>XP_006719084
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRIISVQ 8
           RRIISV+
Sbjct: 470 RRIISVE 476
>XP_006719083
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRIISVQ 8
           RRIISV+
Sbjct: 470 RRIISVE 476
>XP_005251896
          Length = 1063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RRRIISVQP 9
            RRRI   QP
Sbjct: 1054 RRRITFTQP 1062
>XP_005251895
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RRRIISVQP 9
            RRRI   QP
Sbjct: 1068 RRRITFTQP 1076
>XP_005251894
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RRRIISVQP 9
            RRRI   QP
Sbjct: 1077 RRRITFTQP 1085
>XP_006710753
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          +RR+  VQP
Sbjct: 86 QRRLCDVQP 94
>XP_005263530
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          +RR+  VQP
Sbjct: 86 QRRLCDVQP 94
>XP_006710752
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          +RR+  VQP
Sbjct: 86 QRRLCDVQP 94
>XP_006710751
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          +RR+  VQP
Sbjct: 86 QRRLCDVQP 94
>XP_006710750
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          +RR+  VQP
Sbjct: 86 QRRLCDVQP 94
>XP_006710749
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          +RR+  VQP
Sbjct: 86 QRRLCDVQP 94
>XP_006710038
          Length = 163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          RR++ S QP
Sbjct: 28 RRKVQSAQP 36
>XP_006710037
          Length = 165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          RR++ S QP
Sbjct: 28 RRKVQSAQP 36
>XP_006710036
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RRRIISVQP 9
          RR++ S QP
Sbjct: 28 RRKVQSAQP 36
>NP_001138430
          Length = 731

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RRIISVQ 8
           RRIISV+
Sbjct: 469 RRIISVE 475
>NP_055925
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RRRIISVQP 9
            RRRI   QP
Sbjct: 1092 RRRITFTQP 1100
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.146    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 406,658
Number of extensions: 635
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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