Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245202                                                           19     665
NP_001245200                                                           19     665
NP_001161091                                                           19     665
NP_000240                                                              19     665
NP_001161090                                                           19     665
NP_001161089                                                           19     665
NP_001245203                                                           19     665
XP_005265223                                                           19     665
XP_005265221                                                           19     665
XP_005265220                                                           19     665
XP_005265218                                                           19     665
NP_001005619                                                           17    4312
NP_001005731                                                           17    4312
NP_000204                                                              17    4312
XP_005257369                                                           17    4312
XP_005257368                                                           17    4312
XP_006721933                                                           17    4312
XP_006721932                                                           17    4312
XP_006721931                                                           17    4312
XP_006721930                                                           17    4312
XP_005257366                                                           17    4312
XP_006721929                                                           17    4312
NP_775899                                                              16    5631
NP_001121683                                                           16    7355
NP_116258                                                              16    7355
XP_006717206                                                           16    7355
XP_005252108                                                           16    7355
NP_005383                                                              16    7355
NP_619639                                                              15    9605
NP_733842                                                              15    9605
NP_115649                                                              15    9605
NP_002896                                                              15    9605
NP_690621                                                              15    9605
NP_690620                                                              15    9605
NP_690619                                                              15    9605
NP_061180                                                              15    9605
NP_002812                                                              15    9605
NP_001257327                                                           15    9605
NP_001186700                                                           15    9605
XP_006716661                                                           15    9605
>NP_001245202
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 256 RRRIINLT 263
>NP_001245200
          Length = 687

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 497 RRRIINLT 504
>NP_001161091
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 256 RRRIINLT 263
>NP_000240
          Length = 756

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 497 RRRIINLT 504
>NP_001161090
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 256 RRRIINLT 263
>NP_001161089
          Length = 658

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 399 RRRIINLT 406
>NP_001245203
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 256 RRRIINLT 263
>XP_005265223
          Length = 415

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 156 RRRIINLT 163
>XP_005265221
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 256 RRRIINLT 263
>XP_005265220
          Length = 515

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 256 RRRIINLT 263
>XP_005265218
          Length = 687

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           RRRIINLT
Sbjct: 428 RRRIINLT 435
>NP_001005619
          Length = 1805

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RRIINLTV 9
           RR++N+T+
Sbjct: 976 RRLVNITI 983
>NP_001005731
          Length = 1752

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RRIINLTV 9
           RR++N+T+
Sbjct: 976 RRLVNITI 983
>NP_000204
          Length = 1822

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RRIINLTV 9
           RR++N+T+
Sbjct: 976 RRLVNITI 983
>XP_005257369
          Length = 1752

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RRIINLTV 9
           RR++N+T+
Sbjct: 976 RRLVNITI 983
>XP_005257368
          Length = 1875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RRIINLTV 9
           RR++N+T+
Sbjct: 976 RRLVNITI 983
>XP_006721933
          Length = 1787

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RRIINLTV 9
            RR++N+T+
Sbjct: 1011 RRLVNITI 1018
>XP_006721932
          Length = 1821

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RRIINLTV 9
           RR++N+T+
Sbjct: 922 RRLVNITI 929
>XP_006721931
          Length = 1840

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RRIINLTV 9
            RR++N+T+
Sbjct: 1011 RRLVNITI 1018
>XP_006721930
          Length = 1857

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RRIINLTV 9
            RR++N+T+
Sbjct: 1011 RRLVNITI 1018
>XP_005257366
          Length = 1875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   RRIINLTV 9
           RR++N+T+
Sbjct: 976 RRLVNITI 983
>XP_006721929
          Length = 1910

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    RRIINLTV 9
            RR++N+T+
Sbjct: 1011 RRLVNITI 1018
>NP_775899
          Length = 4462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    RRRIINLT 8
            ++R+INLT
Sbjct: 3700 KQRVINLT 3707
>NP_001121683
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RIINLTV 9
          RI+NLTV
Sbjct: 54 RIMNLTV 60
>NP_116258
          Length = 583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  RIINLTV 9
          RI+NLTV
Sbjct: 83 RIMNLTV 89
>XP_006717206
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           R+R++N+T
Sbjct: 186 RKRVLNVT 193
>XP_005252108
          Length = 1097

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           R+R++N+T
Sbjct: 186 RKRVLNVT 193
>NP_005383
          Length = 1096

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   RRRIINLT 8
           R+R++N+T
Sbjct: 186 RKRVLNVT 193
>NP_619639
          Length = 4074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RIINLTV 9
            RI+N+TV
Sbjct: 1081 RIVNVTV 1087
>NP_733842
          Length = 3396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RIINLTV 9
            RI+N+TV
Sbjct: 1081 RIVNVTV 1087
>NP_115649
          Length = 195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RRIINLT 8
          RRI+N+T
Sbjct: 55 RRILNVT 61
>NP_002896
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRRIINLT 8
           R R+IN+T
Sbjct: 155 RGRVINIT 162
>NP_690621
          Length = 1014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRRIINLTV 9
           RR+ +N+TV
Sbjct: 400 RRQDVNITV 408
>NP_690620
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRRIINLTV 9
           RR+ +N+TV
Sbjct: 400 RRQDVNITV 408
>NP_690619
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRRIINLTV 9
           RR+ +N+TV
Sbjct: 400 RRQDVNITV 408
>NP_061180
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RRIINL 7
           RRIINL
Sbjct: 122 RRIINL 127
>NP_002812
          Length = 1070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRRIINLTV 9
           RR+ +N+TV
Sbjct: 400 RRQDVNITV 408
>NP_001257327
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRRIINLTV 9
           RR+ +N+TV
Sbjct: 408 RRQDVNITV 416
>NP_001186700
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRRIINLT 8
           R R+IN+T
Sbjct: 155 RGRVINIT 162
>XP_006716661
          Length = 166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RRIINL 7
           RRIINL
Sbjct: 122 RRIINL 127
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.346    0.155    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 396,138
Number of extensions: 447
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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