Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_361014                                                              20     299
NP_001243998                                                           20     299
NP_060626                                                              18    1482
NP_056193                                                              18    1482
NP_001253989                                                           17    2528
NP_001253990                                                           17    2528
NP_001253988                                                           17    2528
NP_055563                                                              17    2528
XP_006712217                                                           17    2528
NP_758859                                                              17    4312
NP_071900                                                              17    4312
NP_001243463                                                           17    4312
NP_001269166                                                           17    4312
NP_001269167                                                           17    4312
NP_075049                                                              17    4312
NP_612808                                                              17    4312
XP_006714967                                                           17    4312
XP_006714966                                                           17    4312
XP_005266018                                                           17    4312
XP_005266017                                                           17    4312
XP_006714965                                                           17    4312
XP_006714964                                                           17    4312
XP_005266016                                                           17    4312
NP_000466                                                              16    5631
NP_775323                                                              16    5631
NP_003023                                                              16    5631
NP_031371                                                              16    5631
NP_004642                                                              16    5631
XP_005272731                                                           16    5631
XP_005266819                                                           16    5631
XP_006722604                                                           16    5631
XP_006719245                                                           16    5631
XP_006719244                                                           16    5631
XP_005247777                                                           16    5631
XP_005247776                                                           16    5631
XP_005247774                                                           16    5631
XP_006713797                                                           16    5631
NP_005471                                                              16    5631
NP_689588                                                              16    5631
NP_000255                                                              16    7355
NP_940880                                                              16    7355
NP_060833                                                              16    7355
NP_001026879                                                           16    7355
NP_079174                                                              16    7355
NP_001277260                                                           16    7355
XP_003960886                                                           16    7355
XP_006726697                                                           16    7355
XP_003846488                                                           16    7355
XP_006722969                                                           16    7355
XP_006722968                                                           16    7355
XP_005259703                                                           16    7355
XP_005270007                                                           16    7355
XP_005270006                                                           16    7355
XP_005270005                                                           16    7355
XP_005270004                                                           16    7355
XP_005270003                                                           16    7355
XP_006710327                                                           16    7355
XP_005275805                                                           16    7355
NP_002818                                                              15    9605
NP_001265547                                                           15    9605
NP_001514                                                              15    9605
NP_795352                                                              15    9605
XP_005258891                                                           15    9605
XP_006715469                                                           15    9605
XP_005266931                                                           15    9605
XP_006710341                                                           15    9605
XP_005270404                                                           15    9605
XP_005270402                                                           15    9605
XP_005270400                                                           15    9605
XP_006710340                                                           15    9605
XP_005270398                                                           15    9605
XP_006710339                                                           15    9605
XP_006710338                                                           15    9605
NP_001073974                                                           15    9605
NP_001003                                                              15    9605
>NP_361014
          Length = 707

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  RRQTGGSLR 9
          RR+TGGSLR
Sbjct: 12 RRRTGGSLR 20
>NP_001243998
          Length = 176

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  RRQTGGSLR 9
          RR+TGGSLR
Sbjct: 12 RRRTGGSLR 20
>NP_060626
          Length = 4363

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    RQTGGSL 8
            RQTGGSL
Sbjct: 2194 RQTGGSL 2200
>NP_056193
          Length = 4388

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    RQTGGSL 8
            RQTGGSL
Sbjct: 2194 RQTGGSL 2200
>NP_001253989
          Length = 445

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQTGGSLR 9
           RR+ GG+LR
Sbjct: 372 RRRVGGTLR 380
>NP_001253990
          Length = 450

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQTGGSLR 9
           RR+ GG+LR
Sbjct: 377 RRRVGGTLR 385
>NP_001253988
          Length = 458

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQTGGSLR 9
           RR+ GG+LR
Sbjct: 385 RRRVGGTLR 393
>NP_055563
          Length = 470

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQTGGSLR 9
           RR+ GG+LR
Sbjct: 397 RRRVGGTLR 405
>XP_006712217
          Length = 256

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQTGGSLR 9
           RR+ GG+LR
Sbjct: 183 RRRVGGTLR 191
>NP_758859
          Length = 2427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           R+ GGSLR
Sbjct: 803 RERGGSLR 810
>NP_071900
          Length = 2696

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RQTGGSLR 9
            R+ GGSLR
Sbjct: 1072 RERGGSLR 1079
>NP_001243463
          Length = 318

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RRQTGGSLR 9
          R++ GGSLR
Sbjct: 23 RQRPGGSLR 31
>NP_001269166
          Length = 893

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RRQTGGSL 8
          R+Q GGSL
Sbjct: 77 RKQCGGSL 84
>NP_001269167
          Length = 822

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RRQTGGSL 8
          R+Q GGSL
Sbjct: 77 RKQCGGSL 84
>NP_075049
          Length = 823

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RRQTGGSL 8
          R+Q GGSL
Sbjct: 78 RKQCGGSL 85
>NP_612808
          Length = 894

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  RRQTGGSL 8
          R+Q GGSL
Sbjct: 78 RKQCGGSL 85
>XP_006714967
          Length = 1327

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RQTGGSLR 9
            R+ GGSLR
Sbjct: 1072 RERGGSLR 1079
>XP_006714966
          Length = 1499

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RQTGGSLR 9
            R+ GGSLR
Sbjct: 1072 RERGGSLR 1079
>XP_005266018
          Length = 2427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           R+ GGSLR
Sbjct: 803 RERGGSLR 810
>XP_005266017
          Length = 2427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           R+ GGSLR
Sbjct: 803 RERGGSLR 810
>XP_006714965
          Length = 2427

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           R+ GGSLR
Sbjct: 803 RERGGSLR 810
>XP_006714964
          Length = 2696

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RQTGGSLR 9
            R+ GGSLR
Sbjct: 1072 RERGGSLR 1079
>XP_005266016
          Length = 2696

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RQTGGSLR 9
            R+ GGSLR
Sbjct: 1072 RERGGSLR 1079
>NP_000466
          Length = 470

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRQTGGS 7
           RR+TGG+
Sbjct: 325 RRETGGN 331
>NP_775323
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RQTGGSLR 9
          RQT GSLR
Sbjct: 75 RQTLGSLR 82
>NP_003023
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RQTGGSLR 9
          RQT GSLR
Sbjct: 75 RQTLGSLR 82
>NP_031371
          Length = 1845

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGGSLR 9
           TGGSLR
Sbjct: 724 TGGSLR 729
>NP_004642
          Length = 963

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGGSLR 9
           TGGSLR
Sbjct: 672 TGGSLR 677
>XP_005272731
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGGSLR 9
           TGGSLR
Sbjct: 399 TGGSLR 404
>XP_005266819
          Length = 1790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGGSLR 9
           TGGSLR
Sbjct: 669 TGGSLR 674
>XP_006722604
          Length = 1847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGGSLR 9
           TGGSLR
Sbjct: 726 TGGSLR 731
>XP_006719245
          Length = 776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRQTGGSLR 9
           RR+T GS R
Sbjct: 231 RRETAGSSR 239
>XP_006719244
          Length = 868

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRQTGGSLR 9
           RR+T GS R
Sbjct: 231 RRETAGSSR 239
>XP_005247777
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RQTGGSLR 9
          RQT GSLR
Sbjct: 75 RQTLGSLR 82
>XP_005247776
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RQTGGSLR 9
          RQT GSLR
Sbjct: 75 RQTLGSLR 82
>XP_005247774
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RQTGGSLR 9
          RQT GSLR
Sbjct: 75 RQTLGSLR 82
>XP_006713797
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  RQTGGSLR 9
          RQT GSLR
Sbjct: 75 RQTLGSLR 82
>NP_005471
          Length = 778

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRQTGGSLR 9
           RR+T GS R
Sbjct: 231 RRETAGSSR 239
>NP_689588
          Length = 777

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TGGSLR 9
           TGGSLR
Sbjct: 639 TGGSLR 644
>NP_000255
          Length = 1447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RRQTGGSLR 9
          RR+TGG  R
Sbjct: 33 RRRTGGLRR 41
>NP_940880
          Length = 832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRQTGGS 7
           R+QTGG+
Sbjct: 677 RQQTGGA 683
>NP_060833
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  RRQTGGSL 8
          RRQT G L
Sbjct: 21 RRQTSGPL 28
>NP_001026879
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  RRQTGGSL 8
          RRQT G L
Sbjct: 21 RRQTSGPL 28
>NP_079174
          Length = 801

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTGGSLR 9
           Q GGSLR
Sbjct: 476 QRGGSLR 482
>NP_001277260
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTGGSLR 9
           Q GGSLR
Sbjct: 432 QRGGSLR 438
>XP_003960886
          Length = 164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRQTGGSL 8
           R+Q GG+L
Sbjct: 126 RKQNGGAL 133
>XP_006726697
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTGGSLR 9
           Q GGSLR
Sbjct: 244 QPGGSLR 250
>XP_003846488
          Length = 163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRQTGGSL 8
           R+Q GG+L
Sbjct: 125 RKQNGGAL 132
>XP_006722969
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTGGSLR 9
           Q GGSLR
Sbjct: 432 QRGGSLR 438
>XP_006722968
          Length = 896

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTGGSLR 9
           Q GGSLR
Sbjct: 571 QRGGSLR 577
>XP_005259703
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTGGSLR 9
           Q GGSLR
Sbjct: 613 QRGGSLR 619
>XP_005270007
          Length = 232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  RRQTGGSL 8
          RRQT G L
Sbjct: 21 RRQTSGPL 28
>XP_005270006
          Length = 241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  RRQTGGSL 8
          RRQT G L
Sbjct: 21 RRQTSGPL 28
>XP_005270005
          Length = 259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  RRQTGGSL 8
          RRQT G L
Sbjct: 21 RRQTSGPL 28
>XP_005270004
          Length = 265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  RRQTGGSL 8
          RRQT G L
Sbjct: 21 RRQTSGPL 28
>XP_005270003
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  RRQTGGSL 8
          RRQT G L
Sbjct: 21 RRQTSGPL 28
>XP_006710327
          Length = 161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRQTGGSL 8
           R+Q GG+L
Sbjct: 123 RKQNGGAL 130
>XP_005275805
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QTGGSLR 9
           Q GGSLR
Sbjct: 162 QPGGSLR 168
>NP_002818
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RQTGGSLR 9
           R  GGSLR
Sbjct: 373 RVVGGSLR 380
>NP_001265547
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RQTGGSLR 9
           R  GGSLR
Sbjct: 300 RVVGGSLR 307
>NP_001514
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RRQTGG 6
           RR+TGG
Sbjct: 568 RRRTGG 573
>NP_795352
          Length = 1801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           +QT GSLR
Sbjct: 207 QQTTGSLR 214
>XP_005258891
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RRQTGG 6
           RR+TGG
Sbjct: 567 RRRTGG 572
>XP_006715469
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  RRQTGG 6
          RRQ+GG
Sbjct: 60 RRQSGG 65
>XP_005266931
          Length = 1283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RRQTGG 6
           RRQ+GG
Sbjct: 108 RRQSGG 113
>XP_006710341
          Length = 1296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           +QT GSLR
Sbjct: 207 QQTTGSLR 214
>XP_005270404
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           +QT GSLR
Sbjct: 207 QQTTGSLR 214
>XP_005270402
          Length = 1454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           +QT GSLR
Sbjct: 207 QQTTGSLR 214
>XP_005270400
          Length = 1668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           +QT GSLR
Sbjct: 207 QQTTGSLR 214
>XP_006710340
          Length = 1815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           +QT GSLR
Sbjct: 207 QQTTGSLR 214
>XP_005270398
          Length = 1882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           +QT GSLR
Sbjct: 207 QQTTGSLR 214
>XP_006710339
          Length = 1896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           +QT GSLR
Sbjct: 207 QQTTGSLR 214
>XP_006710338
          Length = 1896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RQTGGSLR 9
           +QT GSLR
Sbjct: 207 QQTTGSLR 214
>NP_001073974
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TGGSLR 9
           TGGS+R
Sbjct: 171 TGGSIR 176
>NP_001003
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  RRQTGG 6
          RR+TGG
Sbjct: 11 RRKTGG 16
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.136    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 796,939
Number of extensions: 1360
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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