Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     299
XP_006718908                                                           20     299
XP_005271621                                                           20     299
XP_006718907                                                           20     299
XP_006718906                                                           20     299
XP_005271619                                                           20     299
XP_005271618                                                           20     299
NP_659444                                                              18    1935
XP_005258689                                                           18    1935
XP_006720785                                                           18    1935
NP_115821                                                              18    1935
NP_001277959                                                           17    2528
NP_001013669                                                           17    2528
XP_006724358                                                           17    2528
XP_006724355                                                           17    2528
NP_001186346                                                           17    3301
XP_006725394                                                           17    3301
XP_006725393                                                           17    3301
XP_006722055                                                           17    3301
XP_006722054                                                           17    3301
NP_001272328                                                           17    4312
NP_001028227                                                           17    4312
NP_001272330                                                           17    4312
NP_055151                                                              17    4312
NP_001272329                                                           17    4312
NP_001272331                                                           17    4312
NP_001272332                                                           17    4312
NP_060089                                                              17    4312
NP_001230469                                                           16    5631
NP_001239537                                                           16    5631
NP_009043                                                              16    5631
NP_001230470                                                           16    5631
NP_001239536                                                           16    5631
XP_005256979                                                           16    5631
XP_006721694                                                           16    5631
XP_006711565                                                           16    5631
XP_006711563                                                           16    5631
XP_006711562                                                           16    5631
XP_006711561                                                           16    5631
NP_001263629                                                           16    7355
NP_612202                                                              16    7355
NP_001092107                                                           16    7355
NP_612508                                                              16    7355
NP_001269955                                                           16    7355
XP_006717722                                                           16    7355
NP_001278296                                                           15    9605
NP_001278295                                                           15    9605
NP_001180450                                                           15    9605
NP_001139281                                                           15    9605
NP_001180449                                                           15    9605
NP_004649                                                              15    9605
NP_116279                                                              15    9605
NP_001124324                                                           15    9605
NP_036248                                                              15    9605
NP_001070654                                                           15    9605
NP_079005                                                              15    9605
XP_006724357                                                           15    9605
XP_006724356                                                           15    9605
XP_006724354                                                           15    9605
XP_006723449                                                           15    9605
XP_005258754                                                           15    9605
XP_005258753                                                           15    9605
XP_006719705                                                           15    9605
XP_005254008                                                           15    9605
XP_006719704                                                           15    9605
XP_005254007                                                           15    9605
XP_006711658                                                           15    9605
XP_005273393                                                           15    9605
XP_006711657                                                           15    9605
XP_006711656                                                           15    9605
XP_005273392                                                           15    9605
XP_006711655                                                           15    9605
XP_006710202                                                           15    9605
NP_116238                                                              15    9605
>NP_000042
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRQLAKGRD 9
            RRQL KGRD
Sbjct: 2712 RRQLVKGRD 2720
>XP_006718908
          Length = 1708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRQLAKGRD 9
            RRQL KGRD
Sbjct: 1364 RRQLVKGRD 1372
>XP_005271621
          Length = 2708

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRQLAKGRD 9
            RRQL KGRD
Sbjct: 2364 RRQLVKGRD 2372
>XP_006718907
          Length = 3050

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRQLAKGRD 9
            RRQL KGRD
Sbjct: 2706 RRQLVKGRD 2714
>XP_006718906
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRQLAKGRD 9
            RRQL KGRD
Sbjct: 2712 RRQLVKGRD 2720
>XP_005271619
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRQLAKGRD 9
            RRQL KGRD
Sbjct: 2712 RRQLVKGRD 2720
>XP_005271618
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRQLAKGRD 9
            RRQL KGRD
Sbjct: 2712 RRQLVKGRD 2720
>NP_659444
          Length = 1033

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQLAKGRD 9
           +RQ+ KGRD
Sbjct: 350 KRQMDKGRD 358
>XP_005258689
          Length = 934

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQLAKGRD 9
           +RQ+ KGRD
Sbjct: 251 KRQMDKGRD 259
>XP_006720785
          Length = 1079

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RRQLAKGRD 9
           RRQ  KGRD
Sbjct: 813 RRQKEKGRD 821
>NP_115821
          Length = 1044

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   RRQLAKGRD 9
           RRQ  KGRD
Sbjct: 874 RRQKEKGRD 882
>NP_001277959
          Length = 477

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQLAKGRD 9
           RR+L KGR+
Sbjct: 221 RRRLTKGRE 229
>NP_001013669
          Length = 570

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQLAKGRD 9
           RR+L KGR+
Sbjct: 314 RRRLTKGRE 322
>XP_006724358
          Length = 529

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQLAKGRD 9
           RR+L KGR+
Sbjct: 221 RRRLTKGRE 229
>XP_006724355
          Length = 622

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RRQLAKGRD 9
           RR+L KGR+
Sbjct: 314 RRRLTKGRE 322
>NP_001186346
          Length = 1491

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RRQLAKGR 8
            RR+LA+GR
Sbjct: 1320 RRRLARGR 1327
>XP_006725394
          Length = 1408

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RRQLAKGR 8
            RR+LA+GR
Sbjct: 1237 RRRLARGR 1244
>XP_006725393
          Length = 1473

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RRQLAKGR 8
            RR+LA+GR
Sbjct: 1302 RRRLARGR 1309
>XP_006722055
          Length = 1408

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RRQLAKGR 8
            RR+LA+GR
Sbjct: 1237 RRRLARGR 1244
>XP_006722054
          Length = 1473

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    RRQLAKGR 8
            RR+LA+GR
Sbjct: 1302 RRRLARGR 1309
>NP_001272328
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RQLAKGRD 9
           RQ+A+G+D
Sbjct: 93  RQMAQGKD 100
>NP_001028227
          Length = 324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RQLAKGRD 9
          RQ+A+G+D
Sbjct: 45 RQMAQGKD 52
>NP_001272330
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RQLAKGRD 9
           RQ+A+G+D
Sbjct: 105 RQMAQGKD 112
>NP_055151
          Length = 384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RQLAKGRD 9
           RQ+A+G+D
Sbjct: 105 RQMAQGKD 112
>NP_001272329
          Length = 362

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RQLAKGRD 9
          RQ+A+G+D
Sbjct: 83 RQMAQGKD 90
>NP_001272331
          Length = 345

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  RQLAKGRD 9
          RQ+A+G+D
Sbjct: 66 RQMAQGKD 73
>NP_001272332
          Length = 262

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RQLAKGRD 9
           RQ+A+G+D
Sbjct: 105 RQMAQGKD 112
>NP_060089
          Length = 517

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RR+L KGR
Sbjct: 391 RRELEKGR 398
>NP_001230469
          Length = 621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RRQLAKG 7
           RRQL KG
Sbjct: 278 RRQLGKG 284
>NP_001239537
          Length = 836

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RRQL +GR
Sbjct: 828 RRQLLQGR 835
>NP_009043
          Length = 956

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RRQL +GR
Sbjct: 948 RRQLLQGR 955
>NP_001230470
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RRQLAKG 7
           RRQL KG
Sbjct: 220 RRQLGKG 226
>NP_001239536
          Length = 947

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RRQL +GR
Sbjct: 939 RRQLLQGR 946
>XP_005256979
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RRQLAKG 7
           RRQL KG
Sbjct: 220 RRQLGKG 226
>XP_006721694
          Length = 621

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RRQLAKG 7
           RRQL KG
Sbjct: 278 RRQLGKG 284
>XP_006711565
          Length = 701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RRQL +GR
Sbjct: 693 RRQLLQGR 700
>XP_006711563
          Length = 918

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RRQL +GR
Sbjct: 910 RRQLLQGR 917
>XP_006711562
          Length = 918

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RRQL +GR
Sbjct: 910 RRQLLQGR 917
>XP_006711561
          Length = 1013

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RRQLAKGR 8
            RRQL +GR
Sbjct: 1005 RRQLLQGR 1012
>NP_001263629
          Length = 891

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRQLAKGRD 9
           R+QL  GRD
Sbjct: 399 RQQLELGRD 407
>NP_612202
          Length = 892

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RRQLAKGRD 9
           R+QL  GRD
Sbjct: 399 RQQLELGRD 407
>NP_001092107
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRQLAKGRD 9
           RR+L++ RD
Sbjct: 152 RRRLSRNRD 160
>NP_612508
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRQLAKGRD 9
           RR+L++ RD
Sbjct: 152 RRRLSRNRD 160
>NP_001269955
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RRQLAKGR 8
          +RQ+ KGR
Sbjct: 15 KRQIPKGR 22
>XP_006717722
          Length = 590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRQLAKGRD 9
           RR+L++ RD
Sbjct: 152 RRRLSRNRD 160
>NP_001278296
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RRQ+ +GR
Sbjct: 680 RRQVGQGR 687
>NP_001278295
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RRQ+ +GR
Sbjct: 774 RRQVGQGR 781
>NP_001180450
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RQLAKGRD 9
           RQL  GRD
Sbjct: 703 RQLLLGRD 710
>NP_001139281
          Length = 2036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    RRQLAK 6
            RRQLAK
Sbjct: 1649 RRQLAK 1654
>NP_001180449
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RQLAKGRD 9
           RQL  GRD
Sbjct: 733 RQLLLGRD 740
>NP_004649
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RQLAKGRD 9
           RQL  GRD
Sbjct: 731 RQLLLGRD 738
>NP_116279
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRQLAKGRD 9
            +R+L K RD
Sbjct: 1413 QRELCKNRD 1421
>NP_001124324
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RRQLAK 6
           RRQLAK
Sbjct: 118 RRQLAK 123
>NP_036248
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RRQLAK 6
           RRQLAK
Sbjct: 118 RRQLAK 123
>NP_001070654
          Length = 2003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    RRQLAK 6
            RRQLAK
Sbjct: 1616 RRQLAK 1621
>NP_079005
          Length = 1995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    RRQLAK 6
            RRQLAK
Sbjct: 1608 RRQLAK 1613
>XP_006724357
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RR+L KG+
Sbjct: 221 RRRLTKGK 228
>XP_006724356
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RR+L KG+
Sbjct: 314 RRRLTKGK 321
>XP_006724354
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRQLAKGR 8
           RR+L KG+
Sbjct: 314 RRRLTKGK 321
>XP_006723449
          Length = 2003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    RRQLAK 6
            RRQLAK
Sbjct: 1616 RRQLAK 1621
>XP_005258754
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RRQLAK 6
           RRQLAK
Sbjct: 118 RRQLAK 123
>XP_005258753
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RRQLAK 6
           RRQLAK
Sbjct: 118 RRQLAK 123
>XP_006719705
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RQLAKGRD 9
           RQL  GRD
Sbjct: 732 RQLLLGRD 739
>XP_005254008
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RQLAKGRD 9
           RQL  GRD
Sbjct: 732 RQLLLGRD 739
>XP_006719704
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RQLAKGRD 9
           RQL  GRD
Sbjct: 733 RQLLLGRD 740
>XP_005254007
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RQLAKGRD 9
           RQL  GRD
Sbjct: 733 RQLLLGRD 740
>XP_006711658
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRQLAKGRD 9
            +R+L K RD
Sbjct: 1124 QRELCKNRD 1132
>XP_005273393
          Length = 1330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRQLAKGRD 9
            +R+L K RD
Sbjct: 1219 QRELCKNRD 1227
>XP_006711657
          Length = 1330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRQLAKGRD 9
            +R+L K RD
Sbjct: 1219 QRELCKNRD 1227
>XP_006711656
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRQLAKGRD 9
            +R+L K RD
Sbjct: 1413 QRELCKNRD 1421
>XP_005273392
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRQLAKGRD 9
            +R+L K RD
Sbjct: 1413 QRELCKNRD 1421
>XP_006711655
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RRQLAKGRD 9
            +R+L K RD
Sbjct: 1413 QRELCKNRD 1421
>XP_006710202
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RRQLAKG 7
          RR++AKG
Sbjct: 14 RRKIAKG 20
>NP_116238
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRQLAKGRD 9
           RRQ+ +G D
Sbjct: 145 RRQIEQGMD 153
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.139    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 534,277
Number of extensions: 937
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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