Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001136197                                                           18    1482
NP_002040                                                              18    1935
NP_001124390                                                           17    2528
XP_006721893                                                           17    2528
XP_006721892                                                           17    2528
XP_006721891                                                           17    2528
XP_006721890                                                           17    2528
NP_001271132                                                           17    3301
NP_001092095                                                           17    3301
NP_001271131                                                           17    3301
NP_057559                                                              17    3301
NP_001271130                                                           17    3301
NP_694546                                                              17    3301
NP_006494                                                              17    3301
NP_659431                                                              16    7355
NP_001167579                                                           16    7355
NP_006256                                                              15    9605
NP_079279                                                              15    9605
NP_001265381                                                           15    9605
NP_001265380                                                           15    9605
NP_001265382                                                           15    9605
NP_001165882                                                           15    9605
NP_001165883                                                           15    9605
NP_002241                                                              15    9605
NP_009168                                                              15    9605
NP_001129206                                                           15    9605
NP_620409                                                              15    9605
NP_597733                                                              15    9605
NP_057662                                                              15    9605
NP_001035009                                                           15    9605
XP_005258943                                                           15    9605
XP_005258939                                                           15    9605
XP_006719031                                                           15    9605
XP_006719030                                                           15    9605
XP_006719029                                                           15    9605
XP_006719028                                                           15    9605
XP_006719027                                                           15    9605
XP_006719026                                                           15    9605
XP_005274108                                                           15    9605
XP_005246315                                                           15    9605
XP_006712289                                                           15    9605
XP_005246314                                                           15    9605
XP_005246313                                                           15    9605
XP_005246312                                                           15    9605
XP_005246311                                                           15    9605
XP_005246310                                                           15    9605
XP_006712288                                                           15    9605
XP_006712287                                                           15    9605
XP_005246309                                                           15    9605
XP_006712286                                                           15    9605
XP_006710999                                                           15    9605
XP_006710998                                                           15    9605
NP_695003                                                              15    9605
>NP_001136197
          Length = 691

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           RR KRL+VS
Sbjct: 601 RRSKRLVVS 609
>NP_002040
          Length = 413

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R KKRLIVS
Sbjct: 243 RPKKRLIVS 251
>NP_001124390
          Length = 891

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RRKKRLIVS 9
           R+KKRL+++
Sbjct: 104 RKKKRLVIN 112
>XP_006721893
          Length = 713

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RRKKRLIVS 9
           R+KKRL+++
Sbjct: 104 RKKKRLVIN 112
>XP_006721892
          Length = 843

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  RRKKRLIVS 9
          R+KKRL+++
Sbjct: 56 RKKKRLVIN 64
>XP_006721891
          Length = 891

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RRKKRLIVS 9
           R+KKRL+++
Sbjct: 104 RKKKRLVIN 112
>XP_006721890
          Length = 891

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   RRKKRLIVS 9
           R+KKRL+++
Sbjct: 104 RKKKRLVIN 112
>NP_001271132
          Length = 248

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RKKRLIV 8
           RKKRLIV
Sbjct: 184 RKKRLIV 190
>NP_001092095
          Length = 305

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RKKRLIV 8
           RKKRLIV
Sbjct: 241 RKKRLIV 247
>NP_001271131
          Length = 319

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RKKRLIV 8
           RKKRLIV
Sbjct: 255 RKKRLIV 261
>NP_057559
          Length = 311

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RKKRLIV 8
           RKKRLIV
Sbjct: 247 RKKRLIV 253
>NP_001271130
          Length = 325

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RKKRLIV 8
           RKKRLIV
Sbjct: 261 RKKRLIV 267
>NP_694546
          Length = 387

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           RR+KRLI S
Sbjct: 307 RRQKRLIFS 315
>NP_006494
          Length = 418

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           RR+KRLI S
Sbjct: 338 RRQKRLIFS 346
>NP_659431
          Length = 305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RRKKRL 6
          RRKKRL
Sbjct: 81 RRKKRL 86
>NP_001167579
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  RRKKRLIVS 9
          RR+K+LI++
Sbjct: 74 RRRKKLILA 82
>NP_006256
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RRKKRLIV 8
           +RK++LIV
Sbjct: 319 KRKRKLIV 326
>NP_079279
          Length = 1910

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RKKRLI 7
           RKKRLI
Sbjct: 250 RKKRLI 255
>NP_001265381
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 609 RKKKRILKS 617
>NP_001265380
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 642 RKKKRILKS 650
>NP_001265382
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 555 RKKKRILKS 563
>NP_001165882
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           +RK RL+V+
Sbjct: 354 KRKARLVVA 362
>NP_001165883
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           +RK RL+V+
Sbjct: 356 KRKARLVVA 364
>NP_002241
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RRKKRLI 7
          RR+KRL+
Sbjct: 13 RRRKRLL 19
>NP_009168
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 669 RKKKRILKS 677
>NP_001129206
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 194 RKKKRMLES 202
>NP_620409
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           +RK RL+V+
Sbjct: 356 KRKARLVVA 364
>NP_597733
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 194 RKKKRMLES 202
>NP_057662
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRKKRLI 7
           RRK+RL+
Sbjct: 966 RRKERLV 972
>NP_001035009
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 139 RKKKRMLES 147
>XP_005258943
          Length = 251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RRKKRLI 7
          RR+KRL+
Sbjct: 13 RRRKRLL 19
>XP_005258939
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RRKKRLI 7
          RR+KRL+
Sbjct: 13 RRRKRLL 19
>XP_006719031
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 178 RKKKRMLES 186
>XP_006719030
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 178 RKKKRMLES 186
>XP_006719029
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 194 RKKKRMLES 202
>XP_006719028
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 194 RKKKRMLES 202
>XP_006719027
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 194 RKKKRMLES 202
>XP_006719026
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 194 RKKKRMLES 202
>XP_005274108
          Length = 1438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RRKKRLI 7
           RRK+RL+
Sbjct: 963 RRKERLV 969
>XP_005246315
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 477 RKKKRILKS 485
>XP_006712289
          Length = 750

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 669 RKKKRILKS 677
>XP_005246314
          Length = 789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 591 RKKKRILKS 599
>XP_005246313
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 608 RKKKRILKS 616
>XP_005246312
          Length = 817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 619 RKKKRILKS 627
>XP_005246311
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 635 RKKKRILKS 643
>XP_005246310
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 643 RKKKRILKS 651
>XP_006712288
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 647 RKKKRILKS 655
>XP_006712287
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 649 RKKKRILKS 657
>XP_005246309
          Length = 864

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 666 RKKKRILKS 674
>XP_006712286
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           R+KKR++ S
Sbjct: 669 RKKKRILKS 677
>XP_006710999
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           +RK RL+V+
Sbjct: 295 KRKARLVVA 303
>XP_006710998
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RRKKRLIVS 9
           +RK RL+V+
Sbjct: 356 KRKARLVVA 364
>NP_695003
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RRKKRLIV 8
           +RK+RLI+
Sbjct: 305 KRKRRLIL 312
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.144    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 547,901
Number of extensions: 828
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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