Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     869
XP_006718908                                                           19     869
XP_005271621                                                           19     869
XP_006718907                                                           19     869
XP_006718906                                                           19     869
XP_005271619                                                           19     869
XP_005271618                                                           19     869
NP_056289                                                              17    2528
NP_036559                                                              17    4312
NP_001070960                                                           17    4312
NP_001070959                                                           17    4312
NP_001231892                                                           16    5631
NP_001104488                                                           16    5631
NP_660093                                                              16    5631
NP_892009                                                              16    5631
XP_006718429                                                           16    5631
XP_006718428                                                           16    5631
XP_006718427                                                           16    5631
NP_001019554                                                           16    7355
NP_055718                                                              16    7355
XP_006719740                                                           16    7355
XP_006719739                                                           16    7355
XP_006719738                                                           16    7355
XP_005269272                                                           16    7355
NP_940980                                                              15    9605
NP_002323                                                              15    9605
NP_001191890                                                           15    9605
NP_002576                                                              15    9605
NP_001191892                                                           15    9605
NP_001128250                                                           15    9605
NP_006186                                                              15    9605
NP_037452                                                              15    9605
NP_002577                                                              15    9605
NP_060350                                                              15    9605
NP_001158058                                                           15    9605
XP_005268686                                                           15    9605
XP_006717196                                                           15    9605
XP_006717195                                                           15    9605
XP_006717194                                                           15    9605
XP_006717193                                                           15    9605
XP_005264448                                                           15    9605
XP_005264447                                                           15    9605
XP_005264446                                                           15    9605
XP_006711681                                                           15    9605
XP_006711680                                                           15    9605
XP_005245637                                                           15    9605
XP_005245287                                                           15    9605
XP_006711410                                                           15    9605
XP_005245286                                                           15    9605
XP_005245285                                                           15    9605
>NP_000042
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRIRITKNV 9
            RR RITKNV
Sbjct: 2579 RRSRITKNV 2587
>XP_006718908
          Length = 1708

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRIRITKNV 9
            RR RITKNV
Sbjct: 1231 RRSRITKNV 1239
>XP_005271621
          Length = 2708

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRIRITKNV 9
            RR RITKNV
Sbjct: 2231 RRSRITKNV 2239
>XP_006718907
          Length = 3050

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRIRITKNV 9
            RR RITKNV
Sbjct: 2573 RRSRITKNV 2581
>XP_006718906
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRIRITKNV 9
            RR RITKNV
Sbjct: 2579 RRSRITKNV 2587
>XP_005271619
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRIRITKNV 9
            RR RITKNV
Sbjct: 2579 RRSRITKNV 2587
>XP_005271618
          Length = 3056

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RRIRITKNV 9
            RR RITKNV
Sbjct: 2579 RRSRITKNV 2587
>NP_056289
          Length = 626

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   RRIRITKN 8
           R IRITKN
Sbjct: 528 RAIRITKN 535
>NP_036559
          Length = 293

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RRIRITKNV 9
           RRIR TK+V
Sbjct: 161 RRIRPTKDV 169
>NP_001070960
          Length = 293

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RRIRITKNV 9
           RRIR TK+V
Sbjct: 161 RRIRPTKDV 169
>NP_001070959
          Length = 293

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   RRIRITKNV 9
           RRIR TK+V
Sbjct: 161 RRIRPTKDV 169
>NP_001231892
          Length = 2488

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 745 RRLRTVKNI 753
>NP_001104488
          Length = 2365

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 658 RRLRTVKNI 666
>NP_660093
          Length = 2429

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 722 RRLRTVKNI 730
>NP_892009
          Length = 2432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 722 RRLRTVKNI 730
>XP_006718429
          Length = 2416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 673 RRLRTVKNI 681
>XP_006718428
          Length = 2455

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 745 RRLRTVKNI 753
>XP_006718427
          Length = 2465

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 722 RRLRTVKNI 730
>NP_001019554
          Length = 2385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 681 RRMRTVKNI 689
>NP_055718
          Length = 2363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 681 RRMRTVKNI 689
>XP_006719740
          Length = 1863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 181 RRMRTVKNI 189
>XP_006719739
          Length = 2306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 624 RRMRTVKNI 632
>XP_006719738
          Length = 2340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 658 RRMRTVKNI 666
>XP_005269272
          Length = 2356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           RR+R  KN+
Sbjct: 681 RRMRTVKNI 689
>NP_940980
          Length = 2527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RRIRITKNV 9
            RRI + KNV
Sbjct: 2142 RRILLPKNV 2150
>NP_002323
          Length = 4544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RRIRITKNV 9
            RRI I +NV
Sbjct: 2274 RRITIVENV 2282
>NP_001191890
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 287 KRIRYKKNI 295
>NP_002576
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 287 KRIRYKKNI 295
>NP_001191892
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 287 KRIRYKKNI 295
>NP_001128250
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 214 KRIRYKKNI 222
>NP_006186
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 289 KRIRYKKNI 297
>NP_037452
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IRITKNV 9
           +RI+KNV
Sbjct: 684 VRISKNV 690
>NP_002577
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 298 KRIRYKKNI 306
>NP_060350
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RITKNV 9
           RITKN+
Sbjct: 183 RITKNI 188
>NP_001158058
          Length = 3708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRIRITKN 8
           R IR+TK+
Sbjct: 220 RHIRVTKD 227
>XP_005268686
          Length = 2521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RRIRITKNV 9
            RRI + KNV
Sbjct: 2142 RRILLPKNV 2150
>XP_006717196
          Length = 274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 129 KRIRYKKNI 137
>XP_006717195
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 289 KRIRYKKNI 297
>XP_006717194
          Length = 372

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 310 KRIRYKKNI 318
>XP_006717193
          Length = 455

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 310 KRIRYKKNI 318
>XP_005264448
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RITKNV 9
           RITKN+
Sbjct: 183 RITKNI 188
>XP_005264447
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RITKNV 9
           RITKN+
Sbjct: 183 RITKNI 188
>XP_005264446
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   RITKNV 9
           RITKN+
Sbjct: 183 RITKNI 188
>XP_006711681
          Length = 3448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRIRITKN 8
           R IR+TK+
Sbjct: 220 RHIRVTKD 227
>XP_006711680
          Length = 3617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRIRITKN 8
           R IR+TK+
Sbjct: 220 RHIRVTKD 227
>XP_005245637
          Length = 3683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RRIRITKN 8
           R IR+TK+
Sbjct: 220 RHIRVTKD 227
>XP_005245287
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 182 KRIRYKKNI 190
>XP_006711410
          Length = 357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 214 KRIRYKKNI 222
>XP_005245286
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 287 KRIRYKKNI 295
>XP_005245285
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RRIRITKNV 9
           +RIR  KN+
Sbjct: 343 KRIRYKKNI 351
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.146    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 359,006
Number of extensions: 671
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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