Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001156685                                                           19     869
NP_000133                                                              19     869
XP_006713936                                                           19     869
XP_006713934                                                           19     869
XP_006713935                                                           17    2528
XP_006713933                                                           17    2528
NP_060959                                                              17    4312
XP_005245394                                                           17    4312
XP_005245393                                                           17    4312
XP_006711515                                                           17    4312
XP_006711514                                                           17    4312
XP_006711513                                                           17    4312
NP_004230                                                              16    5631
NP_055692                                                              16    5631
XP_006722279                                                           16    5631
XP_006722278                                                           16    5631
XP_005257947                                                           16    5631
XP_005257946                                                           16    5631
XP_005257945                                                           16    5631
XP_006722277                                                           16    5631
XP_005268271                                                           16    5631
XP_005268270                                                           16    5631
XP_006720384                                                           16    5631
NP_002327                                                              16    7355
NP_653303                                                              16    7355
NP_005286                                                              16    7355
XP_006719141                                                           16    7355
XP_006711251                                                           16    7355
XP_005244985                                                           16    7355
XP_005244984                                                           16    7355
XP_006711250                                                           16    7355
XP_006711249                                                           16    7355
XP_006711248                                                           16    7355
XP_005244983                                                           16    7355
NP_075254                                                              15    9605
NP_001107604                                                           15    9605
NP_076427                                                              15    9605
NP_001077393                                                           15    9605
XP_006712765                                                           15    9605
XP_006712764                                                           15    9605
XP_005246844                                                           15    9605
XP_006712763                                                           15    9605
XP_006712762                                                           15    9605
XP_006712761                                                           15    9605
XP_005273316                                                           15    9605
XP_006711593                                                           15    9605
XP_005275790                                                           15    9605
>NP_001156685
          Length = 808

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RQVSLESN 8
           RQVSLESN
Sbjct: 423 RQVSLESN 430
>NP_000133
          Length = 806

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RQVSLESN 8
           RQVSLESN
Sbjct: 421 RQVSLESN 428
>XP_006713936
          Length = 807

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RQVSLESN 8
           RQVSLESN
Sbjct: 421 RQVSLESN 428
>XP_006713934
          Length = 809

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   RQVSLESN 8
           RQVSLESN
Sbjct: 423 RQVSLESN 430
>XP_006713935
          Length = 807

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RQVSLESN 8
           +QVSLESN
Sbjct: 422 QQVSLESN 429
>XP_006713933
          Length = 810

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   RQVSLESN 8
           +QVSLESN
Sbjct: 424 QQVSLESN 431
>NP_060959
          Length = 2964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQVSLESNT 9
          R+V LE NT
Sbjct: 35 REVELEKNT 43
>XP_005245394
          Length = 1741

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQVSLESNT 9
          R+V LE NT
Sbjct: 35 REVELEKNT 43
>XP_005245393
          Length = 2663

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQVSLESNT 9
          R+V LE NT
Sbjct: 35 REVELEKNT 43
>XP_006711515
          Length = 2904

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQVSLESNT 9
          R+V LE NT
Sbjct: 35 REVELEKNT 43
>XP_006711514
          Length = 2964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQVSLESNT 9
          R+V LE NT
Sbjct: 35 REVELEKNT 43
>XP_006711513
          Length = 2964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQVSLESNT 9
          R+V LE NT
Sbjct: 35 REVELEKNT 43
>NP_004230
          Length = 1979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVSLESNT 9
           Q+SLE NT
Sbjct: 702 QLSLEKNT 709
>NP_055692
          Length = 1942

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQVSLESN 8
            +QV LESN
Sbjct: 1305 KQVDLESN 1312
>XP_006722279
          Length = 1578

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQVSLESN 8
           +QV LESN
Sbjct: 941 KQVDLESN 948
>XP_006722278
          Length = 1735

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQVSLESN 8
            +QV LESN
Sbjct: 1098 KQVDLESN 1105
>XP_005257947
          Length = 1935

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQVSLESN 8
            +QV LESN
Sbjct: 1298 KQVDLESN 1305
>XP_005257946
          Length = 1943

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQVSLESN 8
            +QV LESN
Sbjct: 1306 KQVDLESN 1313
>XP_005257945
          Length = 1969

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQVSLESN 8
            +QV LESN
Sbjct: 1332 KQVDLESN 1339
>XP_006722277
          Length = 1970

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQVSLESN 8
            +QV LESN
Sbjct: 1333 KQVDLESN 1340
>XP_005268271
          Length = 1537

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVSLESNT 9
           Q+SLE NT
Sbjct: 260 QLSLEKNT 267
>XP_005268270
          Length = 1950

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVSLESNT 9
           Q+SLE NT
Sbjct: 673 QLSLEKNT 680
>XP_006720384
          Length = 1978

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVSLESNT 9
           Q+SLE NT
Sbjct: 701 QLSLEKNT 708
>NP_002327
          Length = 1613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RQVSLESN 8
           R++SLE+N
Sbjct: 643 RRISLETN 650
>NP_653303
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQVSLESN 8
           R+VSLE N
Sbjct: 198 RKVSLEGN 205
>NP_005286
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSLESNT 9
           +SLESNT
Sbjct: 105 LSLESNT 111
>XP_006719141
          Length = 1613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RQVSLESN 8
           R++SLE+N
Sbjct: 643 RRISLETN 650
>XP_006711251
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQVSLESN 8
           R+VSLE N
Sbjct: 104 RKVSLEGN 111
>XP_005244985
          Length = 481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQVSLESN 8
           R+VSLE N
Sbjct: 198 RKVSLEGN 205
>XP_005244984
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQVSLESN 8
           R+VSLE N
Sbjct: 198 RKVSLEGN 205
>XP_006711250
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQVSLESN 8
           R+VSLE N
Sbjct: 198 RKVSLEGN 205
>XP_006711249
          Length = 526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQVSLESN 8
           R+VSLE N
Sbjct: 198 RKVSLEGN 205
>XP_006711248
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQVSLESN 8
           R+VSLE N
Sbjct: 171 RKVSLEGN 178
>XP_005244983
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQVSLESN 8
           R+VSLE N
Sbjct: 198 RKVSLEGN 205
>NP_075254
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   QVSLESN 8
           +VSLESN
Sbjct: 310 KVSLESN 316
>NP_001107604
          Length = 2694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   QVSLESN 8
           QVSLE N
Sbjct: 986 QVSLEKN 992
>NP_076427
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQVSLESNT 9
           RQ++ +SNT
Sbjct: 475 RQMNFKSNT 483
>NP_001077393
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQVSLESNT 9
           RQ++ +SNT
Sbjct: 229 RQMNFKSNT 237
>XP_006712765
          Length = 2679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   QVSLESN 8
           QVSLE N
Sbjct: 958 QVSLEKN 964
>XP_006712764
          Length = 2697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    QVSLESN 8
            QVSLE N
Sbjct: 1015 QVSLEKN 1021
>XP_005246844
          Length = 2707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   QVSLESN 8
           QVSLE N
Sbjct: 986 QVSLEKN 992
>XP_006712763
          Length = 2716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    QVSLESN 8
            QVSLE N
Sbjct: 1015 QVSLEKN 1021
>XP_006712762
          Length = 2723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    QVSLESN 8
            QVSLE N
Sbjct: 1015 QVSLEKN 1021
>XP_006712761
          Length = 2736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    QVSLESN 8
            QVSLE N
Sbjct: 1015 QVSLEKN 1021
>XP_005273316
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQVSLESNT 9
           RQ++ +SNT
Sbjct: 229 RQMNFKSNT 237
>XP_006711593
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQVSLESNT 9
           RQ++ +SNT
Sbjct: 475 RQMNFKSNT 483
>XP_005275790
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QVSLESNT 9
           QVSL  NT
Sbjct: 104 QVSLSENT 111
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.294    0.107    0.242 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 319,378
Number of extensions: 451
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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