Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           19     665
NP_060785                                                              19     665
NP_361014                                                              19     665
NP_071750                                                              19     665
XP_005256148                                                           19     665
XP_006721307                                                           19     665
XP_005256144                                                           19     665
XP_005256143                                                           19     665
XP_005256142                                                           19     665
NP_001036236                                                           16    5631
NP_005347                                                              16    5631
XP_005270921                                                           16    5631
XP_005270920                                                           16    5631
XP_005270919                                                           16    5631
NP_056994                                                              16    7355
XP_005264407                                                           16    7355
XP_005264406                                                           16    7355
XP_005264405                                                           16    7355
NP_055880                                                              15    9605
NP_001271165                                                           15    9605
NP_065871                                                              15    9605
NP_001098721                                                           15    9605
NP_078891                                                              15    9605
NP_055548                                                              15    9605
NP_001171526                                                           15    9605
NP_001271166                                                           15    9605
NP_001171527                                                           15    9605
NP_619648                                                              15    9605
XP_005271520                                                           15    9605
XP_005271519                                                           15    9605
XP_005271518                                                           15    9605
XP_005248691                                                           15    9605
XP_005248689                                                           15    9605
XP_005248654                                                           15    9605
XP_005248653                                                           15    9605
>NP_001013433
          Length = 589

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QSLTSGME 9
           QSLTSGME
Sbjct: 463 QSLTSGME 470
>NP_060785
          Length = 627

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QSLTSGME 9
           QSLTSGME
Sbjct: 501 QSLTSGME 508
>NP_361014
          Length = 707

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QSLTSGME 9
           QSLTSGME
Sbjct: 581 QSLTSGME 588
>NP_071750
          Length = 486

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RQSLTSGME 9
           RQSLTSG E
Sbjct: 436 RQSLTSGQE 444
>XP_005256148
          Length = 278

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RQSLTSGME 9
           RQSLTSG E
Sbjct: 228 RQSLTSGQE 236
>XP_006721307
          Length = 370

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RQSLTSGME 9
           RQSLTSG E
Sbjct: 320 RQSLTSGQE 328
>XP_005256144
          Length = 486

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RQSLTSGME 9
           RQSLTSG E
Sbjct: 436 RQSLTSGQE 444
>XP_005256143
          Length = 486

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RQSLTSGME 9
           RQSLTSG E
Sbjct: 436 RQSLTSGQE 444
>XP_005256142
          Length = 486

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RQSLTSGME 9
           RQSLTSG E
Sbjct: 436 RQSLTSGQE 444
>NP_001036236
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSLTSGME 9
           QSLT+G E
Sbjct: 101 QSLTTGQE 108
>NP_005347
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSLTSGME 9
           QSLT+G E
Sbjct: 101 QSLTTGQE 108
>XP_005270921
          Length = 553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSLTSGME 9
           QSLT+G E
Sbjct: 145 QSLTTGQE 152
>XP_005270920
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSLTSGME 9
           QSLT+G E
Sbjct: 159 QSLTTGQE 166
>XP_005270919
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QSLTSGME 9
           QSLT+G E
Sbjct: 159 QSLTTGQE 166
>NP_056994
          Length = 746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QSLTSGME 9
           +S+TSG+E
Sbjct: 632 ESITSGVE 639
>XP_005264407
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QSLTSGME 9
           +S+TSG+E
Sbjct: 473 ESITSGVE 480
>XP_005264406
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QSLTSGME 9
           +S+TSG+E
Sbjct: 485 ESITSGVE 492
>XP_005264405
          Length = 781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QSLTSGME 9
           +S+TSG+E
Sbjct: 632 ESITSGVE 639
>NP_055880
          Length = 1989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    RQSLTSGME 9
            ++ LTSGM+
Sbjct: 1140 KKPLTSGMD 1148
>NP_001271165
          Length = 1539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QSLTSGME 9
           QSL  GME
Sbjct: 445 QSLIEGME 452
>NP_065871
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RQSLTSGME 9
           R+SL  GME
Sbjct: 394 RESLKLGME 402
>NP_001098721
          Length = 1539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QSLTSGME 9
           QSL  GME
Sbjct: 445 QSLIEGME 452
>NP_078891
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQSLTSGM 8
           R SLTSG+
Sbjct: 454 RLSLTSGL 461
>NP_055548
          Length = 1539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QSLTSGME 9
           QSL  GME
Sbjct: 445 QSLIEGME 452
>NP_001171526
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQSLTSGM 8
           R SLTSG+
Sbjct: 454 RLSLTSGL 461
>NP_001271166
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QSLTSGME 9
           QSL  GME
Sbjct: 445 QSLIEGME 452
>NP_001171527
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQSLTSGM 8
           R SLTSG+
Sbjct: 454 RLSLTSGL 461
>NP_619648
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QSLTSGME 9
           +SLT+G+E
Sbjct: 297 RSLTAGLE 304
>XP_005271520
          Length = 1801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQSLTSGME 9
           ++ LTSGM+
Sbjct: 952 KKPLTSGMD 960
>XP_005271519
          Length = 1833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQSLTSGME 9
           ++ LTSGM+
Sbjct: 984 KKPLTSGMD 992
>XP_005271518
          Length = 1982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    RQSLTSGME 9
            ++ LTSGM+
Sbjct: 1133 KKPLTSGMD 1141
>XP_005248691
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QSLTSGME 9
           QSL  GME
Sbjct: 445 QSLIEGME 452
>XP_005248689
          Length = 1539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QSLTSGME 9
           QSL  GME
Sbjct: 445 QSLIEGME 452
>XP_005248654
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQSLTSGM 8
           R SLTSG+
Sbjct: 207 RLSLTSGL 214
>XP_005248653
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQSLTSGM 8
           R SLTSG+
Sbjct: 495 RLSLTSGL 502
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.302    0.113    0.272 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 391,438
Number of extensions: 469
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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