Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1135
NP_001035957                                                           18    1135
XP_006721990                                                           18    1135
XP_006721989                                                           18    1135
XP_005258041                                                           18    1135
XP_006721988                                                           18    1135
XP_006721987                                                           18    1135
XP_006721986                                                           18    1135
XP_005258040                                                           18    1135
XP_006721985                                                           18    1135
NP_001186068                                                           17    4312
NP_067032                                                              17    4312
NP_001186067                                                           17    4312
NP_001017535                                                           16    5631
NP_000367                                                              16    5631
NP_001017536                                                           16    5631
NP_689418                                                              16    5631
NP_001159716                                                           16    5631
NP_001159718                                                           16    5631
NP_068600                                                              16    5631
NP_001159717                                                           16    5631
NP_115545                                                              16    5631
XP_006719650                                                           16    5631
XP_006718000                                                           16    5631
NP_062559                                                              16    7355
XP_005256435                                                           16    7355
XP_005256434                                                           16    7355
XP_005264952                                                           16    7355
NP_002728                                                              15    9605
NP_065087                                                              15    9605
NP_060569                                                              15    9605
NP_056041                                                              15    9605
NP_001258712                                                           15    9605
NP_001230332                                                           15    9605
XP_005255273                                                           15    9605
XP_005255272                                                           15    9605
XP_005255271                                                           15    9605
XP_005255270                                                           15    9605
XP_005255268                                                           15    9605
XP_005255267                                                           15    9605
>NP_000258
          Length = 2818

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRVIAILD 9
            RQRV AILD
Sbjct: 1947 RQRVTAILD 1955
>NP_001035957
          Length = 2839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRVIAILD 9
            RQRV AILD
Sbjct: 1968 RQRVTAILD 1976
>XP_006721990
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRVIAILD 9
            RQRV AILD
Sbjct: 1978 RQRVTAILD 1986
>XP_006721989
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRVIAILD 9
            RQRV AILD
Sbjct: 1978 RQRVTAILD 1986
>XP_005258041
          Length = 2836

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRVIAILD 9
            RQRV AILD
Sbjct: 1947 RQRVTAILD 1955
>XP_006721988
          Length = 2846

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRVIAILD 9
            RQRV AILD
Sbjct: 1957 RQRVTAILD 1965
>XP_006721987
          Length = 2849

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRVIAILD 9
            RQRV AILD
Sbjct: 1978 RQRVTAILD 1986
>XP_006721986
          Length = 2854

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRVIAILD 9
            RQRV AILD
Sbjct: 1965 RQRVTAILD 1973
>XP_005258040
          Length = 2857

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRVIAILD 9
            RQRV AILD
Sbjct: 1968 RQRVTAILD 1976
>XP_006721985
          Length = 2867

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRVIAILD 9
            RQRV AILD
Sbjct: 1978 RQRVTAILD 1986
>NP_001186068
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQRVIAILD 9
           RQRV+ +LD
Sbjct: 240 RQRVLFLLD 248
>NP_067032
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQRVIAILD 9
           RQRV+ +LD
Sbjct: 240 RQRVLFLLD 248
>NP_001186067
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQRVIAILD 9
           RQRV+ +LD
Sbjct: 240 RQRVLFLLD 248
>NP_001017535
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RQRVIAIL 8
           +QR+IAIL
Sbjct: 128 QQRIIAIL 135
>NP_000367
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RQRVIAIL 8
           +QR+IAIL
Sbjct: 128 QQRIIAIL 135
>NP_001017536
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RQRVIAIL 8
           +QR+IAIL
Sbjct: 178 QQRIIAIL 185
>NP_689418
          Length = 839

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQRVIAILD 9
           RQR++ I+D
Sbjct: 254 RQRLVTIVD 262
>NP_001159716
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQRVIAILD 9
           R+ VIA+LD
Sbjct: 252 RKNVIALLD 260
>NP_001159718
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQRVIAILD 9
           R+ VIA+LD
Sbjct: 310 RKNVIALLD 318
>NP_068600
          Length = 592

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQRVIAILD 9
           R+ VIA+LD
Sbjct: 310 RKNVIALLD 318
>NP_001159717
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQRVIAILD 9
           R+ VIA+LD
Sbjct: 198 RKNVIALLD 206
>NP_115545
          Length = 780

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RVIAILD 9
           RVIA+LD
Sbjct: 236 RVIAVLD 242
>XP_006719650
          Length = 427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RQRVIAIL 8
           +QR+IAIL
Sbjct: 128 QQRIIAIL 135
>XP_006718000
          Length = 420

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQRVIAILD 9
           R+ VIA+LD
Sbjct: 138 RKNVIALLD 146
>NP_062559
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   RQRVIAILD 9
           R R++ +LD
Sbjct: 109 RDRIVVVLD 117
>XP_005256435
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  RQRVIAILD 9
          R R++ +LD
Sbjct: 57 RDRIVVVLD 65
>XP_005256434
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  RQRVIAILD 9
          R R++ +LD
Sbjct: 75 RDRIVVVLD 83
>XP_005264952
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  RQRVIAIL 8
          R+RV+A+L
Sbjct: 55 RERVLAVL 62
>NP_002728
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QRVIAILD 9
           +RV+A+LD
Sbjct: 388 KRVLALLD 395
>NP_065087
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RQRVIAILD 9
           R+R + ILD
Sbjct: 250 RRRTVGILD 258
>NP_060569
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQRVIAILD 9
          +QRV  ILD
Sbjct: 53 QQRVFQILD 61
>NP_056041
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QRVIAILD 9
           QR+ A+LD
Sbjct: 821 QRIAALLD 828
>NP_001258712
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQRVIAILD 9
          +QRV  ILD
Sbjct: 53 QQRVFQILD 61
>NP_001230332
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QRVIAILD 9
           QR+ A+LD
Sbjct: 803 QRIAALLD 810
>XP_005255273
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QRVIAILD 9
           QR+ A+LD
Sbjct: 821 QRIAALLD 828
>XP_005255272
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QRVIAILD 9
           QR+ A+LD
Sbjct: 821 QRIAALLD 828
>XP_005255271
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QRVIAILD 9
           QR+ A+LD
Sbjct: 821 QRIAALLD 828
>XP_005255270
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QRVIAILD 9
           QR+ A+LD
Sbjct: 803 QRIAALLD 810
>XP_005255268
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QRVIAILD 9
           QR+ A+LD
Sbjct: 805 QRIAALLD 812
>XP_005255267
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QRVIAILD 9
           QR+ A+LD
Sbjct: 819 QRIAALLD 826
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.343    0.154    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 356,276
Number of extensions: 515
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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