Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              20     390
XP_006716142                                                           20     390
XP_005250088                                                           20     390
XP_006716141                                                           20     390
XP_005250085                                                           20     390
XP_006716140                                                           20     390
XP_005250084                                                           20     390
XP_005250083                                                           20     390
XP_005250082                                                           20     390
NP_056020                                                              17    2528
NP_115565                                                              17    2528
NP_006276                                                              17    2528
XP_006720028                                                           17    2528
XP_005268363                                                           17    2528
XP_005268362                                                           17    2528
XP_005268358                                                           17    2528
XP_005268360                                                           17    2528
XP_005268357                                                           17    2528
XP_005268356                                                           17    2528
NP_001035877                                                           17    3301
NP_001035814                                                           17    3301
NP_056062                                                              17    3301
XP_006721215                                                           17    3301
XP_006721214                                                           17    3301
XP_006721213                                                           17    3301
XP_006721212                                                           17    3301
XP_005255869                                                           17    3301
XP_006721211                                                           17    3301
NP_001268639                                                           17    4312
NP_001268640                                                           17    4312
NP_056156                                                              17    4312
NP_001268641                                                           17    4312
XP_006712451                                                           17    4312
XP_005263965                                                           17    4312
XP_005263964                                                           17    4312
XP_006711829                                                           16    5631
NP_006074                                                              16    5631
NP_579875                                                              16    7355
NP_758847                                                              16    7355
NP_001020528                                                           16    7355
NP_005238                                                              15    9605
NP_001269135                                                           15    9605
NP_005857                                                              15    9605
NP_001269136                                                           15    9605
NP_001269134                                                           15    9605
NP_066554                                                              15    9605
NP_005520                                                              15    9605
NP_114480                                                              15    9605
NP_940853                                                              15    9605
NP_057635                                                              15    9605
NP_001124386                                                           15    9605
NP_006797                                                              15    9605
NP_110451                                                              15    9605
NP_001009921                                                           15    9605
NP_001243404                                                           15    9605
NP_061737                                                              15    9605
XP_005261676                                                           15    9605
XP_006724320                                                           15    9605
XP_006724026                                                           15    9605
XP_005253448                                                           15    9605
XP_005250695                                                           15    9605
XP_006713619                                                           15    9605
XP_005247308                                                           15    9605
XP_006710661                                                           15    9605
XP_005245920                                                           15    9605
XP_006710660                                                           15    9605
XP_006710659                                                           15    9605
XP_006710658                                                           15    9605
XP_006710657                                                           15    9605
NP_056118                                                              15    9605
NP_115540                                                              15    9605
>NP_733751
          Length = 4911

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRSELFFP 9
            RQRSE FFP
Sbjct: 3077 RQRSEPFFP 3085
>XP_006716142
          Length = 4927

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRSELFFP 9
            RQRSE FFP
Sbjct: 3094 RQRSEPFFP 3102
>XP_005250088
          Length = 4928

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRSELFFP 9
            RQRSE FFP
Sbjct: 3094 RQRSEPFFP 3102
>XP_006716141
          Length = 4959

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRSELFFP 9
            RQRSE FFP
Sbjct: 3094 RQRSEPFFP 3102
>XP_005250085
          Length = 4979

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRSELFFP 9
            RQRSE FFP
Sbjct: 3094 RQRSEPFFP 3102
>XP_006716140
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRSELFFP 9
            RQRSE FFP
Sbjct: 3094 RQRSEPFFP 3102
>XP_005250084
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRSELFFP 9
            RQRSE FFP
Sbjct: 3094 RQRSEPFFP 3102
>XP_005250083
          Length = 4982

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRSELFFP 9
            RQRSE FFP
Sbjct: 3093 RQRSEPFFP 3101
>XP_005250082
          Length = 4983

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQRSELFFP 9
            RQRSE FFP
Sbjct: 3094 RQRSEPFFP 3102
>NP_056020
          Length = 1134

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R+R ELFF
Sbjct: 465 REREELFF 472
>NP_115565
          Length = 1191

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R+R ELFF
Sbjct: 465 REREELFF 472
>NP_006276
          Length = 626

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RQRSELFFP 9
           R RS+LF P
Sbjct: 354 RSRSDLFLP 362
>XP_006720028
          Length = 1134

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R+R ELFF
Sbjct: 465 REREELFF 472
>XP_005268363
          Length = 1134

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R+R ELFF
Sbjct: 465 REREELFF 472
>XP_005268362
          Length = 1134

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R+R ELFF
Sbjct: 465 REREELFF 472
>XP_005268358
          Length = 1139

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R+R ELFF
Sbjct: 465 REREELFF 472
>XP_005268360
          Length = 1139

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R+R ELFF
Sbjct: 465 REREELFF 472
>XP_005268357
          Length = 1171

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R+R ELFF
Sbjct: 465 REREELFF 472
>XP_005268356
          Length = 1192

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R+R ELFF
Sbjct: 465 REREELFF 472
>NP_001035877
          Length = 953

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R RSELF+
Sbjct: 346 RNRSELFY 353
>NP_001035814
          Length = 953

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R RSELF+
Sbjct: 346 RNRSELFY 353
>NP_056062
          Length = 956

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R RSELF+
Sbjct: 349 RNRSELFY 356
>XP_006721215
          Length = 943

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R RSELF+
Sbjct: 346 RNRSELFY 353
>XP_006721214
          Length = 953

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R RSELF+
Sbjct: 346 RNRSELFY 353
>XP_006721213
          Length = 953

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R RSELF+
Sbjct: 346 RNRSELFY 353
>XP_006721212
          Length = 953

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R RSELF+
Sbjct: 346 RNRSELFY 353
>XP_005255869
          Length = 953

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R RSELF+
Sbjct: 346 RNRSELFY 353
>XP_006721211
          Length = 953

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQRSELFF 8
           R RSELF+
Sbjct: 346 RNRSELFY 353
>NP_001268639
          Length = 730

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSELFFP 9
           RSEL FP
Sbjct: 260 RSELLFP 266
>NP_001268640
          Length = 717

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSELFFP 9
           RSEL FP
Sbjct: 247 RSELLFP 253
>NP_056156
          Length = 741

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSELFFP 9
           RSEL FP
Sbjct: 271 RSELLFP 277
>NP_001268641
          Length = 605

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSELFFP 9
           RSEL FP
Sbjct: 135 RSELLFP 141
>XP_006712451
          Length = 710

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSELFFP 9
           RSEL FP
Sbjct: 271 RSELLFP 277
>XP_005263965
          Length = 725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSELFFP 9
           RSEL FP
Sbjct: 271 RSELLFP 277
>XP_005263964
          Length = 738

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSELFFP 9
           RSEL FP
Sbjct: 268 RSELLFP 274
>XP_006711829
          Length = 658

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQRSELFFP 9
          R R+E FFP
Sbjct: 2  RPRTEGFFP 10
>NP_006074
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QRSELFFP 9
           +R+ELF P
Sbjct: 227 ERNELFLP 234
>NP_579875
          Length = 436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RQRSELFF 8
          R+R+E FF
Sbjct: 56 RERNEYFF 63
>NP_758847
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  RQRSELFF 8
          R+R+E FF
Sbjct: 56 RERNEYFF 63
>NP_001020528
          Length = 155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RSELFFP 9
          R+EL+FP
Sbjct: 23 RAELWFP 29
>NP_005238
          Length = 239

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   QRSELFFP 9
           Q+S LF P
Sbjct: 173 QKSSLFLP 180
>NP_001269135
          Length = 123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  RSELFFP 9
          +SE+F+P
Sbjct: 42 KSEVFYP 48
>NP_005857
          Length = 223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RSELFFP 9
           +SE+F+P
Sbjct: 142 KSEVFYP 148
>NP_001269136
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RSELFFP 9
           +SE+F+P
Sbjct: 122 KSEVFYP 128
>NP_001269134
          Length = 155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   RSELFFP 9
           +SE+F+P
Sbjct: 142 KSEVFYP 148
>NP_066554
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RQRSEL 6
           RQRSEL
Sbjct: 344 RQRSEL 349
>NP_005520
          Length = 4391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    QRSELFFP 9
            Q SEL FP
Sbjct: 1727 QGSELHFP 1734
>NP_114480
          Length = 837

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   QRSELFFP 9
           Q+S L FP
Sbjct: 765 QKSHLIFP 772
>NP_940853
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  RSELFFP 9
          R+ELF P
Sbjct: 27 RNELFLP 33
>NP_057635
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RQRSELFFP 9
           R+R   FFP
Sbjct: 505 RERGRPFFP 513
>NP_001124386
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QRSELFFP 9
           Q SEL FP
Sbjct: 217 QISELIFP 224
>NP_006797
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QRSELFFP 9
           Q SEL FP
Sbjct: 173 QISELIFP 180
>NP_110451
          Length = 627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  RSELFFP 9
          RS+LF P
Sbjct: 9  RSDLFLP 15
>NP_001009921
          Length = 1428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RQRSELFFP 9
            +QR  L+FP
Sbjct: 1137 QQREALWFP 1145
>NP_001243404
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RQRSEL 6
           RQRSEL
Sbjct: 360 RQRSEL 365
>NP_061737
          Length = 935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   QRSELFFP 9
           Q+S L FP
Sbjct: 765 QKSHLIFP 772
>XP_005261676
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RQRSEL 6
           RQRSEL
Sbjct: 344 RQRSEL 349
>XP_006724320
          Length = 1006

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RQRSEL 6
           RQRSEL
Sbjct: 344 RQRSEL 349
>XP_006724026
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QRSELFFP 9
           Q SEL FP
Sbjct: 184 QISELIFP 191
>XP_005253448
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   RQRSELFFP 9
           R+R   FFP
Sbjct: 454 RERGRPFFP 462
>XP_005250695
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQRSELF 7
           +QRS+LF
Sbjct: 161 KQRSDLF 167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQRSELF 7
           +QRS+LF
Sbjct: 272 KQRSDLF 278
>XP_006713619
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RQRSELFFP 9
           +QR  L+FP
Sbjct: 565 QQREALWFP 573
>XP_005247308
          Length = 1428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RQRSELFFP 9
            +QR  L+FP
Sbjct: 1137 QQREALWFP 1145
>XP_006710661
          Length = 4057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    QRSELFFP 9
            Q SEL FP
Sbjct: 1910 QGSELHFP 1917
>XP_005245920
          Length = 4392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    QRSELFFP 9
            Q SEL FP
Sbjct: 1728 QGSELHFP 1735
>XP_006710660
          Length = 4397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    QRSELFFP 9
            Q SEL FP
Sbjct: 1727 QGSELHFP 1734
>XP_006710659
          Length = 4556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    QRSELFFP 9
            Q SEL FP
Sbjct: 1886 QGSELHFP 1893
>XP_006710658
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    QRSELFFP 9
            Q SEL FP
Sbjct: 1893 QGSELHFP 1900
>XP_006710657
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    QRSELFFP 9
            Q SEL FP
Sbjct: 1909 QGSELHFP 1916
>NP_056118
          Length = 1426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    RQRSELFFP 9
            +QR  L+FP
Sbjct: 1135 QQREALWFP 1143
>NP_115540
          Length = 561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQRSELF 7
           +QRS+LF
Sbjct: 368 KQRSDLF 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQRSELF 7
           +QRS+LF
Sbjct: 479 KQRSDLF 485
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.148    0.453 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 483,115
Number of extensions: 823
Number of successful extensions: 73
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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