Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              19     665
NP_733762                                                              19     665
XP_006713860                                                           19     665
XP_006713859                                                           19     665
XP_005247910                                                           19     665
XP_005247909                                                           19     665
NP_037412                                                              17    2528
XP_005273918                                                           17    2528
NP_619542                                                              17    3301
XP_005274600                                                           17    3301
NP_001273560                                                           17    4312
NP_056312                                                              17    4312
NP_001273416                                                           17    4312
XP_006720531                                                           17    4312
XP_005254344                                                           17    4312
XP_006719923                                                           17    4312
XP_006719922                                                           17    4312
XP_006719920                                                           17    4312
XP_005266554                                                           17    4312
XP_005266553                                                           17    4312
XP_006719919                                                           17    4312
XP_005266551                                                           17    4312
XP_005266550                                                           17    4312
XP_005266549                                                           17    4312
XP_006719918                                                           17    4312
XP_005266548                                                           17    4312
NP_004450                                                              16    5631
NP_872579                                                              16    5631
XP_005257218                                                           16    5631
XP_005257217                                                           16    5631
XP_005257216                                                           16    5631
XP_005257215                                                           16    5631
XP_005257214                                                           16    5631
XP_005257213                                                           16    5631
XP_005257212                                                           16    5631
XP_006721834                                                           16    5631
XP_005257211                                                           16    5631
XP_005257210                                                           16    5631
XP_005257209                                                           16    5631
XP_005257208                                                           16    5631
XP_006721833                                                           16    5631
XP_005257207                                                           16    5631
XP_006712555                                                           16    7355
XP_006712554                                                           16    7355
XP_005263717                                                           16    7355
XP_005263716                                                           16    7355
XP_006712553                                                           16    7355
NP_997246                                                              16    7355
NP_004066                                                              15    9605
NP_001155244                                                           15    9605
NP_000860                                                              15    9605
NP_998786                                                              15    9605
NP_114106                                                              15    9605
NP_938205                                                              15    9605
NP_037413                                                              15    9605
XP_005260739                                                           15    9605
XP_005248395                                                           15    9605
XP_005248394                                                           15    9605
>NP_005179
          Length = 906

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RQNLTKLSL 9
           R+NLTKLSL
Sbjct: 148 RRNLTKLSL 156
>NP_733762
          Length = 982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RQNLTKLSL 9
           R+NLTKLSL
Sbjct: 140 RRNLTKLSL 148
>XP_006713860
          Length = 914

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RQNLTKLSL 9
           R+NLTKLSL
Sbjct: 168 RRNLTKLSL 176
>XP_006713859
          Length = 966

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RQNLTKLSL 9
           R+NLTKLSL
Sbjct: 168 RRNLTKLSL 176
>XP_005247910
          Length = 982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RQNLTKLSL 9
           R+NLTKLSL
Sbjct: 140 RRNLTKLSL 148
>XP_005247909
          Length = 1010

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RQNLTKLSL 9
           R+NLTKLSL
Sbjct: 168 RRNLTKLSL 176
>NP_037412
          Length = 674

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QNLT+LSL
Sbjct: 248 QNLTELSL 255
>XP_005273918
          Length = 674

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QNLT+LSL
Sbjct: 248 QNLTELSL 255
>NP_619542
          Length = 1041

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  QNLTKLSL 9
          QNLTK++L
Sbjct: 87 QNLTKINL 94
>XP_005274600
          Length = 1059

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QNLTK++L
Sbjct: 105 QNLTKINL 112
>NP_001273560
          Length = 1009

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 664 QNVTKLSV 671
>NP_056312
          Length = 555

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQNLTKLSL 9
           R+N+ KLSL
Sbjct: 392 RRNIVKLSL 400
>NP_001273416
          Length = 494

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQNLTKLSL 9
           R+N+ KLSL
Sbjct: 331 RRNIVKLSL 339
>XP_006720531
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQNLTKLSL 9
           R+N+ KLSL
Sbjct: 252 RRNIVKLSL 260
>XP_005254344
          Length = 556

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQNLTKLSL 9
           R+N+ KLSL
Sbjct: 393 RRNIVKLSL 401
>XP_006719923
          Length = 734

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 389 QNVTKLSV 396
>XP_006719922
          Length = 942

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 677 QNVTKLSV 684
>XP_006719920
          Length = 999

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 677 QNVTKLSV 684
>XP_005266554
          Length = 1000

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 677 QNVTKLSV 684
>XP_005266553
          Length = 1007

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 662 QNVTKLSV 669
>XP_006719919
          Length = 1009

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 664 QNVTKLSV 671
>XP_005266551
          Length = 1012

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 667 QNVTKLSV 674
>XP_005266550
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 672 QNVTKLSV 679
>XP_005266549
          Length = 1019

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 674 QNVTKLSV 681
>XP_006719918
          Length = 1021

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 676 QNVTKLSV 683
>XP_005266548
          Length = 1022

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QNLTKLSL 9
           QN+TKLS+
Sbjct: 677 QNVTKLSV 684
>NP_004450
          Length = 2903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2588 KQNATKLS 2595
>NP_872579
          Length = 2920

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2605 KQNATKLS 2612
>XP_005257218
          Length = 2957

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2642 KQNATKLS 2649
>XP_005257217
          Length = 2961

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2588 KQNATKLS 2595
>XP_005257216
          Length = 3015

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2642 KQNATKLS 2649
>XP_005257215
          Length = 3032

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2659 KQNATKLS 2666
>XP_005257214
          Length = 3094

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2721 KQNATKLS 2728
>XP_005257213
          Length = 3095

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2722 KQNATKLS 2729
>XP_005257212
          Length = 3095

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2722 KQNATKLS 2729
>XP_006721834
          Length = 3100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2785 KQNATKLS 2792
>XP_005257211
          Length = 3100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2785 KQNATKLS 2792
>XP_005257210
          Length = 3104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2731 KQNATKLS 2738
>XP_005257209
          Length = 3148

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2785 KQNATKLS 2792
>XP_005257208
          Length = 3157

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2784 KQNATKLS 2791
>XP_006721833
          Length = 3158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2785 KQNATKLS 2792
>XP_005257207
          Length = 3158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RQNLTKLS 8
            +QN TKLS
Sbjct: 2785 KQNATKLS 2792
>XP_006712555
          Length = 1786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQNLTKL 7
           +QNLTK+
Sbjct: 630 KQNLTKI 636
>XP_006712554
          Length = 1885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQNLTKL 7
           +QNLTK+
Sbjct: 729 KQNLTKI 735
>XP_005263717
          Length = 1953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQNLTKL 7
           +QNLTK+
Sbjct: 797 KQNLTKI 803
>XP_005263716
          Length = 1953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQNLTKL 7
           +QNLTK+
Sbjct: 797 KQNLTKI 803
>XP_006712553
          Length = 1953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQNLTKL 7
           +QNLTK+
Sbjct: 797 KQNLTKI 803
>NP_997246
          Length = 1909

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RQNLTKL 7
           +QNLTK+
Sbjct: 797 KQNLTKI 803
>NP_004066
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  NLTKLSL 9
          N+TKLS+
Sbjct: 92 NITKLSI 98
>NP_001155244
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  NLTKLSL 9
          N+TKLS+
Sbjct: 89 NITKLSI 95
>NP_000860
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NLTKLSL 9
           N+TKLS+
Sbjct: 110 NITKLSI 116
>NP_998786
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NLTKLSL 9
           N+TKLS+
Sbjct: 110 NITKLSI 116
>NP_114106
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RQNLTKLSL 9
          R ++TKLSL
Sbjct: 34 RTSVTKLSL 42
>NP_938205
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NLTKLSL 9
           NLT+LSL
Sbjct: 226 NLTELSL 232
>NP_037413
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NLTKLSL 9
           NLT+LSL
Sbjct: 226 NLTELSL 232
>XP_005260739
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   NLTKLSL 9
           NLT+LSL
Sbjct: 226 NLTELSL 232
>XP_005248395
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RQNLTKLSL 9
          R ++TKLSL
Sbjct: 34 RTSVTKLSL 42
>XP_005248394
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  RQNLTKLSL 9
          R ++TKLSL
Sbjct: 33 RTSVTKLSL 41
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.127    0.305 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 332,511
Number of extensions: 552
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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