Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              21     229
XP_006718908                                                           21     229
XP_005271621                                                           21     229
XP_006718907                                                           21     229
XP_006718906                                                           21     229
XP_005271619                                                           21     229
XP_005271618                                                           21     229
NP_659444                                                              17    3301
XP_005258689                                                           17    3301
NP_001272328                                                           17    4312
NP_001028227                                                           17    4312
NP_001272330                                                           17    4312
NP_055151                                                              17    4312
NP_001272329                                                           17    4312
NP_001272331                                                           17    4312
NP_001272332                                                           17    4312
NP_003194                                                              16    5631
NP_001188264                                                           16    5631
XP_005264578                                                           16    5631
XP_005264577                                                           16    5631
NP_004975                                                              16    7355
NP_115492                                                              16    7355
NP_003889                                                              16    7355
NP_001014402                                                           16    7355
NP_056028                                                              16    7355
NP_008922                                                              16    7355
NP_001020026                                                           16    7355
NP_001230183                                                           16    7355
NP_000479                                                              16    7355
NP_001157787                                                           16    7355
NP_079466                                                              16    7355
XP_005266631                                                           16    7355
XP_006718232                                                           16    7355
XP_005252889                                                           16    7355
XP_006715655                                                           16    7355
XP_006715654                                                           16    7355
XP_005264840                                                           16    7355
XP_006712732                                                           16    7355
XP_006712731                                                           16    7355
XP_006712730                                                           16    7355
XP_006712729                                                           16    7355
XP_006712728                                                           16    7355
XP_006712727                                                           16    7355
XP_006712726                                                           16    7355
XP_006712725                                                           16    7355
XP_006712724                                                           16    7355
XP_005264052                                                           16    7355
XP_005263995                                                           16    7355
XP_006712580                                                           16    7355
XP_005263994                                                           16    7355
XP_006712579                                                           16    7355
XP_006712578                                                           16    7355
XP_006712577                                                           16    7355
XP_005245255                                                           16    7355
NP_001180450                                                           15    9605
NP_001180449                                                           15    9605
NP_004649                                                              15    9605
NP_001138944                                                           15    9605
NP_000951                                                              15    9605
NP_653213                                                              15    9605
XP_003403541                                                           15    9605
XP_006722454                                                           15    9605
XP_006722453                                                           15    9605
XP_006722452                                                           15    9605
XP_006722451                                                           15    9605
XP_006722450                                                           15    9605
XP_006722449                                                           15    9605
XP_006722448                                                           15    9605
XP_006722447                                                           15    9605
XP_006719705                                                           15    9605
XP_005254008                                                           15    9605
XP_006719704                                                           15    9605
XP_005254007                                                           15    9605
XP_003846688                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQLAKGRDD 9
            RQL KGRDD
Sbjct: 2713 RQLVKGRDD 2721
>XP_006718908
          Length = 1708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQLAKGRDD 9
            RQL KGRDD
Sbjct: 1365 RQLVKGRDD 1373
>XP_005271621
          Length = 2708

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQLAKGRDD 9
            RQL KGRDD
Sbjct: 2365 RQLVKGRDD 2373
>XP_006718907
          Length = 3050

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQLAKGRDD 9
            RQL KGRDD
Sbjct: 2707 RQLVKGRDD 2715
>XP_006718906
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQLAKGRDD 9
            RQL KGRDD
Sbjct: 2713 RQLVKGRDD 2721
>XP_005271619
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQLAKGRDD 9
            RQL KGRDD
Sbjct: 2713 RQLVKGRDD 2721
>XP_005271618
          Length = 3056

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    RQLAKGRDD 9
            RQL KGRDD
Sbjct: 2713 RQLVKGRDD 2721
>NP_659444
          Length = 1033

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQLAKGRD 8
           RQ+ KGRD
Sbjct: 351 RQMDKGRD 358
>XP_005258689
          Length = 934

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RQLAKGRD 8
           RQ+ KGRD
Sbjct: 252 RQMDKGRD 259
>NP_001272328
          Length = 372

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RQLAKGRD 8
           RQ+A+G+D
Sbjct: 93  RQMAQGKD 100
>NP_001028227
          Length = 324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  RQLAKGRD 8
          RQ+A+G+D
Sbjct: 45 RQMAQGKD 52
>NP_001272330
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RQLAKGRD 8
           RQ+A+G+D
Sbjct: 105 RQMAQGKD 112
>NP_055151
          Length = 384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RQLAKGRD 8
           RQ+A+G+D
Sbjct: 105 RQMAQGKD 112
>NP_001272329
          Length = 362

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  RQLAKGRD 8
          RQ+A+G+D
Sbjct: 83 RQMAQGKD 90
>NP_001272331
          Length = 345

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  RQLAKGRD 8
          RQ+A+G+D
Sbjct: 66 RQMAQGKD 73
>NP_001272332
          Length = 262

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RQLAKGRD 8
           RQ+A+G+D
Sbjct: 105 RQMAQGKD 112
>NP_003194
          Length = 781

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQLAKGRDD 9
           R+LA+ +DD
Sbjct: 147 RELARAQDD 155
>NP_001188264
          Length = 215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQLAKGRDD 9
           R+LA+ +DD
Sbjct: 147 RELARAQDD 155
>XP_005264578
          Length = 710

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQLAKGRDD 9
           R+LA+ +DD
Sbjct: 155 RELARAQDD 163
>XP_005264577
          Length = 789

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQLAKGRDD 9
           R+LA+ +DD
Sbjct: 155 RELARAQDD 163
>NP_004975
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQLAKGRDD 9
           RQLA+ RD+
Sbjct: 712 RQLARLRDE 720
>NP_115492
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AKGRDD 9
           A+GRDD
Sbjct: 158 ARGRDD 163
>NP_003889
          Length = 1496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AKGRDD 9
          A+GRDD
Sbjct: 25 ARGRDD 30
>NP_001014402
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AKGRDD 9
           A+GRDD
Sbjct: 158 ARGRDD 163
>NP_056028
          Length = 1287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RQLAKGRDD 9
            R L KG DD
Sbjct: 1046 RWLGKGMDD 1054
>NP_008922
          Length = 1029

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LAKGRDD 9
          L KG+DD
Sbjct: 16 LVKGKDD 22
>NP_001020026
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LAKGRDD 9
          L KG+DD
Sbjct: 16 LVKGKDD 22
>NP_001230183
          Length = 1241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RQLAKGRDD 9
            R L KG DD
Sbjct: 1046 RWLGKGMDD 1054
>NP_000479
          Length = 464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LAKGRDD 9
           +A+GRDD
Sbjct: 387 VAEGRDD 393
>NP_001157787
          Length = 1941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1832 RQLQQKRDD 1840
>NP_079466
          Length = 1353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1244 RQLQQKRDD 1252
>XP_005266631
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AKGRDD 9
           A+GRDD
Sbjct: 158 ARGRDD 163
>XP_006718232
          Length = 1263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RQLAKGRDD 9
            R L KG DD
Sbjct: 1022 RWLGKGMDD 1030
>XP_005252889
          Length = 1307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RQLAKGRDD 9
            R L KG DD
Sbjct: 1046 RWLGKGMDD 1054
>XP_006715655
          Length = 1288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AKGRDD 9
          A+GRDD
Sbjct: 25 ARGRDD 30
>XP_006715654
          Length = 1495

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  AKGRDD 9
          A+GRDD
Sbjct: 25 ARGRDD 30
>XP_005264840
          Length = 1029

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  LAKGRDD 9
          L KG+DD
Sbjct: 16 LVKGKDD 22
>XP_006712732
          Length = 938

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RQLAKGRDD 9
           RQL + RDD
Sbjct: 829 RQLQQKRDD 837
>XP_006712731
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 993  RQLQQKRDD 1001
>XP_006712730
          Length = 1106

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 997  RQLQQKRDD 1005
>XP_006712729
          Length = 1121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1012 RQLQQKRDD 1020
>XP_006712728
          Length = 1307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1198 RQLQQKRDD 1206
>XP_006712727
          Length = 1319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1210 RQLQQKRDD 1218
>XP_006712726
          Length = 1319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1210 RQLQQKRDD 1218
>XP_006712725
          Length = 1352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1243 RQLQQKRDD 1251
>XP_006712724
          Length = 1353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1244 RQLQQKRDD 1252
>XP_005264052
          Length = 1353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1244 RQLQQKRDD 1252
>XP_005263995
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1273 RQLQQKRDD 1281
>XP_006712580
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1273 RQLQQKRDD 1281
>XP_005263994
          Length = 1496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1387 RQLQQKRDD 1395
>XP_006712579
          Length = 1865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1805 RQLQQKRDD 1813
>XP_006712578
          Length = 1914

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1805 RQLQQKRDD 1813
>XP_006712577
          Length = 1915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RQLAKGRDD 9
            RQL + RDD
Sbjct: 1806 RQLQQKRDD 1814
>XP_005245255
          Length = 416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LAKGRDD 9
           +A+GRDD
Sbjct: 339 VAEGRDD 345
>NP_001180450
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RQLAKGRD 8
           RQL  GRD
Sbjct: 703 RQLLLGRD 710
>NP_001180449
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RQLAKGRD 8
           RQL  GRD
Sbjct: 733 RQLLLGRD 740
>NP_004649
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RQLAKGRD 8
           RQL  GRD
Sbjct: 731 RQLLLGRD 738
>NP_001138944
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RQLAKGRDD 9
           R LAK  DD
Sbjct: 166 RWLAKNEDD 174
>NP_000951
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   QLAKGRDD 9
           QLA GR D
Sbjct: 325 QLASGRRD 332
>NP_653213
          Length = 2211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RQLAKGRDD 9
            R LAK  DD
Sbjct: 1277 RWLAKNEDD 1285
>XP_003403541
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  LAKGRDD 9
          LAK RDD
Sbjct: 49 LAKERDD 55
>XP_006722454
          Length = 1144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RQLAKGRDD 9
           R LAK  DD
Sbjct: 210 RWLAKNEDD 218
>XP_006722453
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RQLAKGRDD 9
           R LAK  DD
Sbjct: 166 RWLAKNEDD 174
>XP_006722452
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RQLAKGRDD 9
           R LAK  DD
Sbjct: 166 RWLAKNEDD 174
>XP_006722451
          Length = 1206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RQLAKGRDD 9
           R LAK  DD
Sbjct: 210 RWLAKNEDD 218
>XP_006722450
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RQLAKGRDD 9
           R LAK  DD
Sbjct: 308 RWLAKNEDD 316
>XP_006722449
          Length = 1256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RQLAKGRDD 9
           R LAK  DD
Sbjct: 308 RWLAKNEDD 316
>XP_006722448
          Length = 1304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RQLAKGRDD 9
           R LAK  DD
Sbjct: 308 RWLAKNEDD 316
>XP_006722447
          Length = 1933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    RQLAKGRDD 9
            R LAK  DD
Sbjct: 999  RWLAKNEDD 1007
>XP_006719705
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RQLAKGRD 8
           RQL  GRD
Sbjct: 732 RQLLLGRD 739
>XP_005254008
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RQLAKGRD 8
           RQL  GRD
Sbjct: 732 RQLLLGRD 739
>XP_006719704
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RQLAKGRD 8
           RQL  GRD
Sbjct: 733 RQLLLGRD 740
>XP_005254007
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RQLAKGRD 8
           RQL  GRD
Sbjct: 733 RQLLLGRD 740
>XP_003846688
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  LAKGRDD 9
          LAK RDD
Sbjct: 49 LAKERDD 55
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.138    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 555,510
Number of extensions: 944
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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