Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055973                                                              17    3301
NP_001243805                                                           17    3301
NP_694856                                                              17    3301
NP_001243806                                                           17    3301
XP_006716811                                                           17    3301
XP_006716810                                                           17    3301
XP_005251476                                                           17    3301
XP_005251475                                                           17    3301
XP_005251473                                                           17    3301
XP_005251474                                                           17    3301
XP_005251472                                                           17    3301
XP_005251471                                                           17    3301
XP_005251470                                                           17    3301
XP_006716809                                                           17    3301
XP_006716808                                                           17    3301
XP_006716807                                                           17    3301
XP_006716806                                                           17    3301
XP_005251468                                                           17    3301
XP_005251467                                                           17    3301
NP_002408                                                              17    4312
NP_001139438                                                           17    4312
XP_006717927                                                           17    4312
NP_000929                                                              17    4312
NP_000157                                                              16    5631
NP_001091111                                                           16    5631
NP_055871                                                              16    5631
NP_001188412                                                           16    7355
NP_001419                                                              16    7355
NP_055752                                                              16    7355
NP_001230124                                                           16    7355
NP_079410                                                              16    7355
NP_689763                                                              16    7355
XP_005256233                                                           16    7355
XP_005256232                                                           16    7355
XP_005256231                                                           16    7355
XP_005256229                                                           16    7355
XP_005256228                                                           16    7355
XP_005256227                                                           16    7355
XP_006721346                                                           16    7355
XP_005256226                                                           16    7355
XP_006721345                                                           16    7355
XP_006721344                                                           16    7355
XP_006721343                                                           16    7355
XP_005256225                                                           16    7355
XP_006717783                                                           16    7355
XP_006717782                                                           16    7355
XP_006714820                                                           16    7355
XP_005268437                                                           16    7355
XP_006710496                                                           16    7355
NP_003360                                                              15    9605
NP_071351                                                              15    9605
XP_006718738                                                           15    9605
XP_006718737                                                           15    9605
XP_006718736                                                           15    9605
XP_005274266                                                           15    9605
XP_005252603                                                           15    9605
>NP_055973
          Length = 1352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>NP_001243805
          Length = 1352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>NP_694856
          Length = 1194

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 733 QKTSLGKI 740
>NP_001243806
          Length = 1352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>XP_006716811
          Length = 1120

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>XP_006716810
          Length = 1206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 733 QKTSLGKI 740
>XP_005251476
          Length = 1206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 733 QKTSLGKI 740
>XP_005251475
          Length = 1206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 733 QKTSLGKI 740
>XP_005251473
          Length = 1206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 733 QKTSLGKI 740
>XP_005251474
          Length = 1206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 733 QKTSLGKI 740
>XP_005251472
          Length = 1206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 733 QKTSLGKI 740
>XP_005251471
          Length = 1206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 733 QKTSLGKI 740
>XP_005251470
          Length = 1284

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>XP_006716809
          Length = 1334

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>XP_006716808
          Length = 1346

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>XP_006716807
          Length = 1352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>XP_006716806
          Length = 1364

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>XP_005251468
          Length = 1364

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>XP_005251467
          Length = 1364

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKTAIGKV 9
           QKT++GK+
Sbjct: 891 QKTSLGKI 898
>NP_002408
          Length = 3256

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RQKTAIGKV 9
            R KT++GKV
Sbjct: 1632 RLKTSLGKV 1640
>NP_001139438
          Length = 2896

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    RQKTAIGKV 9
            R KT++GKV
Sbjct: 1272 RLKTSLGKV 1280
>XP_006717927
          Length = 2406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           R KT++GKV
Sbjct: 782 RLKTSLGKV 790
>NP_000929
          Length = 1174

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QKTAIGKV 9
           QKT IGK+
Sbjct: 145 QKTFIGKI 152
>NP_000157
          Length = 283

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQKTAIGKV 9
          R  TAIG+V
Sbjct: 15 RHSTAIGRV 23
>NP_001091111
          Length = 283

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  RQKTAIGKV 9
          R  TAIG+V
Sbjct: 15 RHSTAIGRV 23
>NP_055871
          Length = 758

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RQKTAIGK 8
           ++KTA+GK
Sbjct: 262 KKKTALGK 269
>NP_001188412
          Length = 341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KTAIGK 8
           KTAIGK
Sbjct: 135 KTAIGK 140
>NP_001419
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KTAIGK 8
           KTAIGK
Sbjct: 228 KTAIGK 233
>NP_055752
          Length = 1132

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RQKTAIGKV 9
          RQK  +GK+
Sbjct: 69 RQKALVGKL 77
>NP_001230124
          Length = 219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RQKTAIGKV 9
          RQK  +GK+
Sbjct: 69 RQKALVGKL 77
>NP_079410
          Length = 2881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>NP_689763
          Length = 729

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RQKTAIGK 8
           R+K+A+GK
Sbjct: 704 RRKSALGK 711
>XP_005256233
          Length = 2391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RQKTAIGKV 9
          ++KT IGK+
Sbjct: 82 KEKTKIGKL 90
>XP_005256232
          Length = 2424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 115 KEKTKIGKL 123
>XP_005256231
          Length = 2573

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>XP_005256229
          Length = 2881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>XP_005256228
          Length = 2882

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>XP_005256227
          Length = 2897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>XP_006721346
          Length = 2898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>XP_005256226
          Length = 2898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>XP_006721345
          Length = 2898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>XP_006721344
          Length = 2898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>XP_006721343
          Length = 2898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>XP_005256225
          Length = 2898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RQKTAIGKV 9
           ++KT IGK+
Sbjct: 589 KEKTKIGKL 597
>XP_006717783
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RQKTAIGKV 9
          RQK  +GK+
Sbjct: 69 RQKALVGKL 77
>XP_006717782
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  RQKTAIGKV 9
          RQK  +GK+
Sbjct: 69 RQKALVGKL 77
>XP_006714820
          Length = 729

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RQKTAIGK 8
           R+K+A+GK
Sbjct: 704 RRKSALGK 711
>XP_005268437
          Length = 735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   RQKTAIGK 8
           R+K+A+GK
Sbjct: 710 RRKSALGK 717
>XP_006710496
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KTAIGK 8
           KTAIGK
Sbjct: 228 KTAIGK 233
>NP_003360
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RQKTAIGK 8
           RQK A+G+
Sbjct: 253 RQKKALGR 260
>NP_071351
          Length = 2752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    QKTAIGKV 9
            +KT +GKV
Sbjct: 2253 RKTVLGKV 2260
>XP_006718738
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RQKTAIGK 8
           RQK A+G+
Sbjct: 253 RQKKALGR 260
>XP_006718737
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RQKTAIGK 8
           RQK A+G+
Sbjct: 253 RQKKALGR 260
>XP_006718736
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RQKTAIGK 8
           RQK A+G+
Sbjct: 253 RQKKALGR 260
>XP_005274266
          Length = 552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RQKTAIGK 8
           RQK A+G+
Sbjct: 106 RQKKALGR 113
>XP_005252603
          Length = 1457

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QKTAIGK 8
            +KTA+GK
Sbjct: 1440 KKTALGK 1446
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.128    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 452,122
Number of extensions: 776
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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