Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              19     869
NP_005913                                                              19     869
XP_005267046                                                           19     869
XP_005267045                                                           19     869
NP_002499                                                              17    2528
XP_006711834                                                           17    2528
NP_001244163                                                           17    3301
NP_001244166                                                           17    3301
NP_001244159                                                           17    3301
NP_001244160                                                           17    3301
NP_001093392                                                           17    3301
NP_001561                                                              17    3301
XP_006724764                                                           17    3301
XP_006724763                                                           17    3301
XP_006724762                                                           17    3301
XP_006724761                                                           17    3301
XP_006724760                                                           17    3301
XP_006724759                                                           17    3301
XP_006724758                                                           17    3301
XP_006724757                                                           17    3301
XP_006724756                                                           17    3301
NP_060826                                                              17    4312
NP_001494                                                              16    5631
NP_001276109                                                           16    5631
NP_001276108                                                           16    5631
NP_001276106                                                           16    5631
XP_006722978                                                           16    5631
XP_005249075                                                           16    5631
XP_005275761                                                           16    5631
NP_112186                                                              16    5631
NP_001276107                                                           16    5631
NP_112503                                                              16    7355
NP_002196                                                              16    7355
NP_000094                                                              16    7355
NP_055827                                                              16    7355
NP_001019554                                                           16    7355
NP_036565                                                              16    7355
NP_000848                                                              16    7355
NP_055718                                                              16    7355
NP_703143                                                              16    7355
XP_006720469                                                           16    7355
XP_005254248                                                           16    7355
XP_005254247                                                           16    7355
XP_006719739                                                           16    7355
XP_006719738                                                           16    7355
XP_005269272                                                           16    7355
XP_006719560                                                           16    7355
XP_005269075                                                           16    7355
XP_005263016                                                           16    7355
XP_005246485                                                           16    7355
NP_060458                                                              16    7355
NP_002102                                                              15    9605
NP_542164                                                              15    9605
NP_001438                                                              15    9605
NP_055288                                                              15    9605
NP_055535                                                              15    9605
XP_006722446                                                           15    9605
XP_006722445                                                           15    9605
XP_006722444                                                           15    9605
XP_006722443                                                           15    9605
XP_005270358                                                           15    9605
XP_006714824                                                           15    9605
>NP_006715
          Length = 1558

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RPFVYKALK 9
           RPFV KALK
Sbjct: 527 RPFVDKALK 535
>NP_005913
          Length = 1608

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RPFVYKALK 9
           RPFV KALK
Sbjct: 527 RPFVDKALK 535
>XP_005267046
          Length = 1554

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RPFVYKALK 9
           RPFV KALK
Sbjct: 527 RPFVDKALK 535
>XP_005267045
          Length = 1604

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RPFVYKALK 9
           RPFV KALK
Sbjct: 527 RPFVDKALK 535
>NP_002499
          Length = 1247

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           PF YKAL+
Sbjct: 312 PFSYKALR 319
>XP_006711834
          Length = 1156

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           PF YKAL+
Sbjct: 312 PFSYKALR 319
>NP_001244163
          Length = 954

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 347 PFPYKVLK 354
>NP_001244166
          Length = 954

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 347 PFPYKVLK 354
>NP_001244159
          Length = 954

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 347 PFPYKVLK 354
>NP_001244160
          Length = 1059

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 373 PFPYKVLK 380
>NP_001093392
          Length = 1137

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 451 PFPYKVLK 458
>NP_001561
          Length = 625

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RPFVYKALK 9
           +PFV+K L+
Sbjct: 232 KPFVFKKLR 240
>XP_006724764
          Length = 861

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 451 PFPYKVLK 458
>XP_006724763
          Length = 901

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 451 PFPYKVLK 458
>XP_006724762
          Length = 903

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 451 PFPYKVLK 458
>XP_006724761
          Length = 1033

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 347 PFPYKVLK 354
>XP_006724760
          Length = 1033

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 347 PFPYKVLK 354
>XP_006724759
          Length = 1033

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 347 PFPYKVLK 354
>XP_006724758
          Length = 1058

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 451 PFPYKVLK 458
>XP_006724757
          Length = 1080

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 394 PFPYKVLK 401
>XP_006724756
          Length = 1124

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PF YK LK
Sbjct: 451 PFPYKVLK 458
>NP_060826
          Length = 442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  PFVYKAL 8
          PF+Y+A+
Sbjct: 30 PFIYRAI 36
>NP_001494
          Length = 840

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FVYKALK 9
           F+YKAL+
Sbjct: 341 FIYKALE 347
>NP_001276109
          Length = 479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           P VYKA++
Sbjct: 414 PLVYKAIQ 421
>NP_001276108
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           P VYKA++
Sbjct: 573 PLVYKAIQ 580
>NP_001276106
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           P VYKA++
Sbjct: 601 PLVYKAIQ 608
>XP_006722978
          Length = 651

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           P VYKA++
Sbjct: 601 PLVYKAIQ 608
>XP_005249075
          Length = 677

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FVYKALK 9
           F+YKAL+
Sbjct: 178 FIYKALE 184
>XP_005275761
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   RPFVYK 6
           +PFVYK
Sbjct: 549 QPFVYK 554
>NP_112186
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           P VYKA++
Sbjct: 601 PLVYKAIQ 608
>NP_001276107
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           P VYKA++
Sbjct: 601 PLVYKAIQ 608
>NP_112503
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RPFVYKAL 8
           RPF  KAL
Sbjct: 145 RPFFMKAL 152
>NP_002196
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   VYKALK 9
           VYKALK
Sbjct: 960 VYKALK 965
>NP_000094
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RPFVYKAL 8
           RPF  KAL
Sbjct: 145 RPFFMKAL 152
>NP_055827
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RPFVYKAL 8
           RP VYK L
Sbjct: 172 RPVVYKYL 179
>NP_001019554
          Length = 2385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   PFVYKA 7
           PF+Y+A
Sbjct: 632 PFIYRA 637
>NP_036565
          Length = 1304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RPFVYKAL 8
           RP+V+K L
Sbjct: 568 RPYVHKIL 575
>NP_000848
          Length = 619

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   PFVYK 6
           PFVYK
Sbjct: 467 PFVYK 471
>NP_055718
          Length = 2363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   PFVYKA 7
           PF+Y+A
Sbjct: 632 PFIYRA 637
>NP_703143
          Length = 337

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PFVYKALK 9
           PFVY  L+
Sbjct: 291 PFVYSLLR 298
>XP_006720469
          Length = 401

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  RPFVYKAL 8
          RPF  KAL
Sbjct: 43 RPFFMKAL 50
>XP_005254248
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RPFVYKAL 8
           RPF  KAL
Sbjct: 145 RPFFMKAL 152
>XP_005254247
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   RPFVYKAL 8
           RPF  KAL
Sbjct: 145 RPFFMKAL 152
>XP_006719739
          Length = 2306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   PFVYKA 7
           PF+Y+A
Sbjct: 575 PFIYRA 580
>XP_006719738
          Length = 2340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   PFVYKA 7
           PF+Y+A
Sbjct: 609 PFIYRA 614
>XP_005269272
          Length = 2356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   PFVYKA 7
           PF+Y+A
Sbjct: 632 PFIYRA 637
>XP_006719560
          Length = 826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           P VY+AL+
Sbjct: 348 PMVYRALE 355
>XP_005269075
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           P VY+AL+
Sbjct: 451 PMVYRALE 458
>XP_005263016
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   PFVYK 6
           PFVYK
Sbjct: 442 PFVYK 446
>XP_005246485
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RPFVYKAL 8
           RP+V+K L
Sbjct: 422 RPYVHKIL 429
>NP_060458
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFVYKALK 9
           P VY+AL+
Sbjct: 451 PMVYRALE 458
>NP_002102
          Length = 3144

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    PFVYKALK 9
            P V KALK
Sbjct: 1429 PLVIKALK 1436
>NP_542164
          Length = 950

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VYKALK 9
           +YKALK
Sbjct: 231 IYKALK 236
>NP_001438
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    RPFVYKAL 8
            +PF Y+AL
Sbjct: 2129 KPFDYQAL 2136
>NP_055288
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFVYKAL 8
           PFV+K L
Sbjct: 136 PFVFKLL 142
>NP_055535
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RPFVYKA 7
           RP+ YKA
Sbjct: 210 RPYDYKA 216
>XP_006722446
          Length = 889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VYKALK 9
           +YKALK
Sbjct: 231 IYKALK 236
>XP_006722445
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VYKALK 9
           +YKALK
Sbjct: 231 IYKALK 236
>XP_006722444
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VYKALK 9
           +YKALK
Sbjct: 231 IYKALK 236
>XP_006722443
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VYKALK 9
           +YKALK
Sbjct: 206 IYKALK 211
>XP_005270358
          Length = 1204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RPFVYKA 7
           RP+ YKA
Sbjct: 210 RPYDYKA 216
>XP_006714824
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    RPFVYKAL 8
            +PF Y+AL
Sbjct: 2129 KPFDYQAL 2136
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.148    0.456 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 530,531
Number of extensions: 657
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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