Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              20     390
NP_005913                                                              20     390
XP_005267046                                                           20     390
XP_005267045                                                           20     390
NP_004873                                                              17    2528
NP_036238                                                              17    2528
NP_001243497                                                           17    3301
NP_003612                                                              17    3301
NP_001243498                                                           17    3301
XP_006718416                                                           17    3301
XP_006718415                                                           17    3301
XP_006718414                                                           17    3301
XP_006718413                                                           17    3301
XP_005253234                                                           17    3301
XP_006718412                                                           17    3301
XP_005253233                                                           17    3301
XP_005253232                                                           17    3301
XP_005253231                                                           17    3301
NP_001034859                                                           17    4312
NP_004477                                                              17    4312
XP_005251989                                                           17    4312
XP_005251988                                                           17    4312
XP_005251987                                                           17    4312
NP_001129710                                                           17    4312
NP_005926                                                              16    5631
NP_001160165                                                           16    5631
NP_001229468                                                           16    5631
NP_054790                                                              16    5631
NP_004425                                                              16    5631
XP_006723818                                                           16    5631
XP_006723816                                                           16    5631
XP_006723815                                                           16    5631
XP_006723814                                                           16    5631
XP_006723813                                                           16    5631
XP_005260405                                                           16    5631
XP_006720137                                                           16    5631
XP_005267457                                                           16    5631
XP_005267456                                                           16    5631
XP_005267455                                                           16    5631
XP_005267454                                                           16    5631
XP_005263070                                                           16    5631
XP_005263069                                                           16    5631
XP_005263068                                                           16    5631
XP_005263067                                                           16    5631
XP_005263066                                                           16    5631
XP_005263065                                                           16    5631
XP_005263064                                                           16    5631
NP_060592                                                              16    7355
NP_006477                                                              16    7355
NP_005091                                                              16    7355
NP_653080                                                              16    7355
NP_113623                                                              16    7355
NP_004790                                                              16    7355
NP_015563                                                              16    7355
NP_001135945                                                           16    7355
NP_005440                                                              16    7355
NP_005473                                                              16    7355
XP_005267292                                                           16    7355
XP_005267291                                                           16    7355
XP_005267290                                                           16    7355
XP_006714786                                                           16    7355
XP_005273409                                                           16    7355
XP_005273408                                                           16    7355
XP_005245356                                                           16    7355
XP_006711490                                                           16    7355
XP_006711489                                                           16    7355
NP_060945                                                              15    9605
NP_005550                                                              15    9605
XP_005261914                                                           15    9605
NP_004277                                                              15    9605
>NP_006715
          Length = 1558

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RPASQSNLK 9
           RPAS+SNLK
Sbjct: 106 RPASRSNLK 114
>NP_005913
          Length = 1608

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RPASQSNLK 9
           RPAS+SNLK
Sbjct: 106 RPASRSNLK 114
>XP_005267046
          Length = 1554

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RPASQSNLK 9
           RPAS+SNLK
Sbjct: 106 RPASRSNLK 114
>XP_005267045
          Length = 1604

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RPASQSNLK 9
           RPAS+SNLK
Sbjct: 106 RPASRSNLK 114
>NP_004873
          Length = 450

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  PASQSNLK 9
          PAS+SN+K
Sbjct: 16 PASKSNIK 23
>NP_036238
          Length = 163

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   PASQSNLK 9
           PASQ+NL+
Sbjct: 155 PASQNNLR 162
>NP_001243497
          Length = 764

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 591 RPADESNL 598
>NP_003612
          Length = 876

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 703 RPADESNL 710
>NP_001243498
          Length = 733

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 560 RPADESNL 567
>XP_006718416
          Length = 784

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 571 RPADESNL 578
>XP_006718415
          Length = 839

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 626 RPADESNL 633
>XP_006718414
          Length = 850

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 637 RPADESNL 644
>XP_006718413
          Length = 887

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 714 RPADESNL 721
>XP_005253234
          Length = 916

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 703 RPADESNL 710
>XP_006718412
          Length = 927

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 714 RPADESNL 721
>XP_005253233
          Length = 937

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 764 RPADESNL 771
>XP_005253232
          Length = 948

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 775 RPADESNL 782
>XP_005253231
          Length = 977

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RPA +SNL
Sbjct: 764 RPADESNL 771
>NP_001034859
          Length = 453

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PASQSNLK 9
           PAS +NLK
Sbjct: 201 PASMNNLK 208
>NP_004477
          Length = 1002

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PASQSNLK 9
           PAS +NLK
Sbjct: 150 PASSANLK 157
>XP_005251989
          Length = 975

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PASQSNLK 9
           PAS +NLK
Sbjct: 150 PASSANLK 157
>XP_005251988
          Length = 1002

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PASQSNLK 9
           PAS +NLK
Sbjct: 177 PASSANLK 184
>XP_005251987
          Length = 1029

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PASQSNLK 9
           PAS +NLK
Sbjct: 177 PASSANLK 184
>NP_001129710
          Length = 316

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  PASQSNLK 9
          PAS +NLK
Sbjct: 64 PASMNNLK 71
>NP_005926
          Length = 1210

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           RP+SQS+ K
Sbjct: 854 RPSSQSSKK 862
>NP_001160165
          Length = 1218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           RP+SQS+ K
Sbjct: 861 RPSSQSSKK 869
>NP_001229468
          Length = 1070

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RPASQSN 7
           RPASQS+
Sbjct: 209 RPASQSD 215
>NP_054790
          Length = 2063

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RPASQSN 7
           RPASQS+
Sbjct: 209 RPASQSD 215
>NP_004425
          Length = 815

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PASQSNLK 9
           PA++SN+K
Sbjct: 124 PATKSNIK 131
>XP_006723818
          Length = 1975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RPASQSN 7
           RPASQS+
Sbjct: 209 RPASQSD 215
>XP_006723816
          Length = 2034

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RPASQSN 7
           RPASQS+
Sbjct: 209 RPASQSD 215
>XP_006723815
          Length = 2051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RPASQSN 7
           RPASQS+
Sbjct: 209 RPASQSD 215
>XP_006723814
          Length = 2052

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RPASQSN 7
           RPASQS+
Sbjct: 209 RPASQSD 215
>XP_006723813
          Length = 2062

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RPASQSN 7
           RPASQS+
Sbjct: 209 RPASQSD 215
>XP_005260405
          Length = 2063

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   RPASQSN 7
           RPASQS+
Sbjct: 209 RPASQSD 215
>XP_006720137
          Length = 790

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PASQSNLK 9
           PA++SN+K
Sbjct: 124 PATKSNIK 131
>XP_005267457
          Length = 802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PASQSNLK 9
           PA++SN+K
Sbjct: 111 PATKSNIK 118
>XP_005267456
          Length = 815

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PASQSNLK 9
           PA++SN+K
Sbjct: 105 PATKSNIK 112
>XP_005267455
          Length = 821

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PASQSNLK 9
           PA++SN+K
Sbjct: 111 PATKSNIK 118
>XP_005267454
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PASQSNLK 9
           PA++SN+K
Sbjct: 124 PATKSNIK 131
>XP_005263070
          Length = 1057

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           RP+SQS+ K
Sbjct: 861 RPSSQSSKK 869
>XP_005263069
          Length = 1211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           RP+SQS+ K
Sbjct: 854 RPSSQSSKK 862
>XP_005263068
          Length = 1216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           RP+SQS+ K
Sbjct: 859 RPSSQSSKK 867
>XP_005263067
          Length = 1217

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           RP+SQS+ K
Sbjct: 861 RPSSQSSKK 869
>XP_005263066
          Length = 1217

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           RP+SQS+ K
Sbjct: 860 RPSSQSSKK 868
>XP_005263065
          Length = 1218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           RP+SQS+ K
Sbjct: 861 RPSSQSSKK 869
>XP_005263064
          Length = 1218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           RP+SQS+ K
Sbjct: 861 RPSSQSSKK 869
>NP_060592
          Length = 645

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RPASQSNLK 9
           RPA Q N K
Sbjct: 125 RPAGQENPK 133
>NP_006477
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   PASQSNL 8
           PASQ+N+
Sbjct: 626 PASQANI 632
>NP_005091
          Length = 1782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PASQSNLK 9
           P+S+SNL+
Sbjct: 150 PSSESNLE 157
>NP_653080
          Length = 1684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  PASQSNLK 9
          P+S+SNL+
Sbjct: 52 PSSESNLE 59
>NP_113623
          Length = 228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PASQSNLK 9
           PA  SNLK
Sbjct: 105 PAGPSNLK 112
>NP_004790
          Length = 1425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RPASQSNLK 9
           RP   SNLK
Sbjct: 580 RPKQPSNLK 588
>NP_015563
          Length = 1366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RPASQSNLK 9
           RP   SNLK
Sbjct: 580 RPKQPSNLK 588
>NP_001135945
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RP SQ+N+
Sbjct: 195 RPRSQNNI 202
>NP_005440
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RP SQ+N+
Sbjct: 307 RPRSQNNI 314
>NP_005473
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   PASQSNL 8
           PASQ+N+
Sbjct: 262 PASQTNM 268
>XP_005267292
          Length = 1677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  PASQSNLK 9
          P+S+SNL+
Sbjct: 45 PSSESNLE 52
>XP_005267291
          Length = 1684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  PASQSNLK 9
          P+S+SNL+
Sbjct: 52 PSSESNLE 59
>XP_005267290
          Length = 1782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   PASQSNLK 9
           P+S+SNL+
Sbjct: 150 PSSESNLE 157
>XP_006714786
          Length = 438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   RPASQS 6
           RPASQS
Sbjct: 249 RPASQS 254
>XP_005273409
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RP SQ+N+
Sbjct: 216 RPRSQNNI 223
>XP_005273408
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   RPASQSNL 8
           RP SQ+N+
Sbjct: 307 RPRSQNNI 314
>XP_005245356
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  RPASQSNLK 9
          RPA Q N K
Sbjct: 50 RPAGQENPK 58
>XP_006711490
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RPASQSNLK 9
           RPA Q N K
Sbjct: 125 RPAGQENPK 133
>XP_006711489
          Length = 609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   RPASQSNLK 9
           RPA Q N K
Sbjct: 125 RPAGQENPK 133
>NP_060945
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  PASQSNL 8
          PA+Q+NL
Sbjct: 85 PATQTNL 91
>NP_005550
          Length = 3075

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    RPASQSNLK 9
            R  SQSNL+
Sbjct: 1180 RVVSQSNLR 1188
>XP_005261914
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           +PA+ SNL+
Sbjct: 517 QPAASSNLQ 525
>NP_004277
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RPASQSNLK 9
           +PA+ SNL+
Sbjct: 629 QPAASSNLQ 637
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.110    0.281 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 594,403
Number of extensions: 995
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package