Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           21     229
NP_055903                                                              21     229
NP_004159                                                              17    2528
NP_009124                                                              17    2528
NP_663782                                                              17    2528
NP_001118                                                              17    2528
XP_005257995                                                           17    2528
XP_005257994                                                           17    2528
XP_005248388                                                           17    2528
XP_005248386                                                           17    2528
XP_006714136                                                           17    2528
NP_001159491                                                           17    2528
NP_001273                                                              17    2528
NP_001025177                                                           17    2528
NP_612449                                                              17    3301
NP_001654                                                              17    4312
NP_001019398                                                           17    4312
NP_001019397                                                           17    4312
NP_001019399                                                           17    4312
NP_001650                                                              17    4312
NP_001649                                                              17    4312
NP_001269340                                                           17    4312
NP_002703                                                              17    4312
NP_001269338                                                           17    4312
NP_001269343                                                           17    4312
NP_001269339                                                           17    4312
NP_001269342                                                           17    4312
NP_001269341                                                           17    4312
NP_001653                                                              17    4312
XP_006719454                                                           17    4312
XP_005268913                                                           17    4312
NP_004295                                                              16    5631
NP_112191                                                              16    5631
NP_997002                                                              16    5631
NP_001265141                                                           16    5631
NP_001265140                                                           16    5631
NP_059988                                                              16    5631
NP_060675                                                              16    5631
XP_005270251                                                           16    5631
XP_005270250                                                           16    5631
NP_002629                                                              16    5631
NP_689732                                                              16    7355
XP_005246390                                                           16    7355
XP_005246389                                                           16    7355
XP_006712382                                                           16    7355
XP_005246387                                                           16    7355
XP_005246386                                                           16    7355
XP_005246385                                                           16    7355
NP_001001711                                                           16    7355
NP_001651                                                              15    9605
NP_001157032                                                           15    9605
NP_689977                                                              15    9605
NP_001772                                                              15    9605
NP_940905                                                              15    9605
NP_001274748                                                           15    9605
NP_001274749                                                           15    9605
NP_001339                                                              15    9605
NP_003239                                                              15    9605
XP_005259566                                                           15    9605
XP_005259565                                                           15    9605
XP_006711360                                                           15    9605
XP_006711359                                                           15    9605
XP_006711358                                                           15    9605
XP_006711357                                                           15    9605
>NP_001155973
          Length = 1833

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RNVSGQDKI 9
           RNVSGQD+I
Sbjct: 285 RNVSGQDRI 293
>NP_055903
          Length = 1723

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   RNVSGQDKI 9
           RNVSGQD+I
Sbjct: 285 RNVSGQDRI 293
>NP_004159
          Length = 664

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   RNVSGQDKI 9
           R+V+GQD+I
Sbjct: 423 RHVNGQDQI 431
>NP_009124
          Length = 324

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RNVSGQDKI 9
           +N+SGQD +
Sbjct: 215 QNISGQDMV 223
>NP_663782
          Length = 939

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RNV GQD +
Sbjct: 881 RNVEGQDML 889
>NP_001118
          Length = 949

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RNV GQD +
Sbjct: 888 RNVEGQDML 896
>XP_005257995
          Length = 951

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RNV GQD +
Sbjct: 893 RNVEGQDML 901
>XP_005257994
          Length = 951

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RNV GQD +
Sbjct: 893 RNVEGQDML 901
>XP_005248388
          Length = 583

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   RNVSGQDKI 9
           R+V+GQD+I
Sbjct: 423 RHVNGQDQI 431
>XP_005248386
          Length = 668

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   RNVSGQDKI 9
           R+V+GQD+I
Sbjct: 423 RHVNGQDQI 431
>XP_006714136
          Length = 347

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   RNVSGQDKI 9
           +N+SGQD +
Sbjct: 238 QNISGQDMV 246
>NP_001159491
          Length = 919

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RNV GQD +
Sbjct: 861 RNVEGQDML 869
>NP_001273
          Length = 937

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RNV GQD +
Sbjct: 879 RNVEGQDML 887
>NP_001025177
          Length = 951

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RNV GQD +
Sbjct: 893 RNVEGQDML 901
>NP_612449
          Length = 673

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RNVSGQDK 8
           RN+SG DK
Sbjct: 499 RNLSGPDK 506
>NP_001654
          Length = 175

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQDKI
Sbjct: 63 DVGGQDKI 70
>NP_001019398
          Length = 181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQDKI
Sbjct: 67 DVGGQDKI 74
>NP_001019397
          Length = 181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQDKI
Sbjct: 67 DVGGQDKI 74
>NP_001019399
          Length = 181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQDKI
Sbjct: 67 DVGGQDKI 74
>NP_001650
          Length = 181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQDKI
Sbjct: 67 DVGGQDKI 74
>NP_001649
          Length = 181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQDKI
Sbjct: 67 DVGGQDKI 74
>NP_001269340
          Length = 237

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RN+ G DK+
Sbjct: 112 RNIEGVDKL 120
>NP_002703
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RN+ G DK+
Sbjct: 155 RNIEGVDKL 163
>NP_001269338
          Length = 317

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RN+ G DK+
Sbjct: 112 RNIEGVDKL 120
>NP_001269343
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RN+ G DK+
Sbjct: 96  RNIEGVDKL 104
>NP_001269339
          Length = 280

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RN+ G DK+
Sbjct: 155 RNIEGVDKL 163
>NP_001269342
          Length = 301

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RN+ G DK+
Sbjct: 96  RNIEGVDKL 104
>NP_001269341
          Length = 344

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RN+ G DK+
Sbjct: 139 RNIEGVDKL 147
>NP_001653
          Length = 180

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQDKI
Sbjct: 67 DVGGQDKI 74
>XP_006719454
          Length = 137

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQDKI
Sbjct: 67 DVGGQDKI 74
>XP_005268913
          Length = 181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQDKI
Sbjct: 67 DVGGQDKI 74
>NP_004295
          Length = 1620

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VSGQDKI 9
           +SG+DKI
Sbjct: 638 ISGEDKI 644
>NP_112191
          Length = 304

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NVSGQDKI 9
           NV+GQD I
Sbjct: 183 NVTGQDVI 190
>NP_997002
          Length = 184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RNVSGQ 6
          RNVSGQ
Sbjct: 46 RNVSGQ 51
>NP_001265141
          Length = 184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RNVSGQ 6
          RNVSGQ
Sbjct: 46 RNVSGQ 51
>NP_001265140
          Length = 184

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RNVSGQ 6
          RNVSGQ
Sbjct: 46 RNVSGQ 51
>NP_059988
          Length = 368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RNVSGQD 7
          RN++GQD
Sbjct: 9  RNMAGQD 15
>NP_060675
          Length = 128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  RNVSGQ 6
          RNVSGQ
Sbjct: 46 RNVSGQ 51
>XP_005270251
          Length = 230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NVSGQDKI 9
           NV+GQD I
Sbjct: 183 NVTGQDVI 190
>XP_005270250
          Length = 304

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NVSGQDKI 9
           NV+GQD I
Sbjct: 183 NVTGQDVI 190
>NP_002629
          Length = 117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQDK+
Sbjct: 52 SVKGQDKV 59
>NP_689732
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNVSGQD 7
           +NV GQD
Sbjct: 859 KNVEGQD 865
>XP_005246390
          Length = 945

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNVSGQD 7
           +NV GQD
Sbjct: 817 KNVEGQD 823
>XP_005246389
          Length = 978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNVSGQD 7
           +NV GQD
Sbjct: 850 KNVEGQD 856
>XP_006712382
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNVSGQD 7
           +NV GQD
Sbjct: 859 KNVEGQD 865
>XP_005246387
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNVSGQD 7
           +NV GQD
Sbjct: 859 KNVEGQD 865
>XP_005246386
          Length = 987

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNVSGQD 7
           +NV GQD
Sbjct: 859 KNVEGQD 865
>XP_005246385
          Length = 1020

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNVSGQD 7
           +NV GQD
Sbjct: 892 KNVEGQD 898
>NP_001001711
          Length = 396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   RNVSGQDK 8
           R VSGQD+
Sbjct: 371 RMVSGQDE 378
>NP_001651
          Length = 180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NVSGQDKI 9
          +V GQD+I
Sbjct: 67 DVGGQDRI 74
>NP_001157032
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RN+SGQ  +
Sbjct: 463 RNLSGQKHV 471
>NP_689977
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RN+SGQ  +
Sbjct: 434 RNLSGQKHV 442
>NP_001772
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NVSGQDK 8
           NV+G DK
Sbjct: 166 NVTGSDK 172
>NP_940905
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    NVSGQD 7
            NV+GQD
Sbjct: 1123 NVTGQD 1128
>NP_001274748
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    NVSGQD 7
            NV+GQD
Sbjct: 1099 NVTGQD 1104
>NP_001274749
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    NVSGQD 7
            NV+GQD
Sbjct: 1056 NVTGQD 1061
>NP_001339
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNVSGQD 7
           RNV G+D
Sbjct: 281 RNVRGED 287
>NP_003239
          Length = 961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   RNVSGQDKI 9
           RNV  +DK+
Sbjct: 871 RNVGWKDKV 879
>XP_005259566
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNVSGQD 7
           RNV G+D
Sbjct: 281 RNVRGED 287
>XP_005259565
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNVSGQD 7
           RNV G+D
Sbjct: 281 RNVRGED 287
>XP_006711360
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NVSGQD 7
           NV+GQD
Sbjct: 687 NVTGQD 692
>XP_006711359
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NVSGQD 7
           NV+GQD
Sbjct: 740 NVTGQD 745
>XP_006711358
          Length = 1118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    NVSGQD 7
            NV+GQD
Sbjct: 1106 NVTGQD 1111
>XP_006711357
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    NVSGQD 7
            NV+GQD
Sbjct: 1130 NVTGQD 1135
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.130    0.342 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 630,051
Number of extensions: 1078
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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