Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              20     509
NP_001263689                                                           20     509
NP_001119584                                                           20     509
NP_001119586                                                           20     509
NP_001263625                                                           20     509
NP_001119590                                                           20     509
NP_001263690                                                           20     509
NP_001119585                                                           20     509
NP_001263624                                                           20     509
NP_001119588                                                           20     509
NP_001119587                                                           20     509
NP_001119589                                                           20     509
NP_001263627                                                           20     509
NP_001263628                                                           20     509
NP_001263626                                                           20     509
NP_001190174                                                           17    3301
NP_001005                                                              17    3301
NP_001191020                                                           17    3301
NP_001189399                                                           17    3301
NP_055797                                                              17    4312
XP_005267484                                                           17    4312
XP_005267481                                                           17    4312
XP_005267480                                                           17    4312
XP_005267479                                                           17    4312
XP_005267478                                                           17    4312
XP_005267477                                                           17    4312
NP_001127965                                                           17    4312
NP_689818                                                              16    5631
XP_006723134                                                           16    5631
XP_006723133                                                           16    5631
XP_006723132                                                           16    5631
XP_006723131                                                           16    5631
XP_006723130                                                           16    5631
XP_006723129                                                           16    5631
NP_004360                                                              16    7355
NP_476508                                                              16    7355
NP_476507                                                              16    7355
NP_005804                                                              16    7355
NP_002733                                                              16    7355
NP_001073351                                                           16    7355
NP_001073350                                                           16    7355
NP_001073349                                                           16    7355
NP_057541                                                              16    7355
NP_001191443                                                           16    7355
XP_005258773                                                           16    7355
XP_005267916                                                           16    7355
XP_005246123                                                           16    7355
XP_005246122                                                           16    7355
XP_006712316                                                           16    7355
XP_006712043                                                           16    7355
XP_006712042                                                           16    7355
XP_006712041                                                           16    7355
XP_005264295                                                           16    7355
XP_005264294                                                           16    7355
NP_009052                                                              15    9605
NP_694972                                                              15    9605
NP_001010848                                                           15    9605
NP_005968                                                              15    9605
NP_001159444                                                           15    9605
NP_001159445                                                           15    9605
NP_001123553                                                           15    9605
NP_689417                                                              15    9605
NP_002653                                                              15    9605
NP_898865                                                              15    9605
NP_898864                                                              15    9605
XP_006720248                                                           15    9605
XP_005267848                                                           15    9605
XP_006719917                                                           15    9605
XP_005266543                                                           15    9605
XP_005266542                                                           15    9605
XP_005269501                                                           15    9605
XP_005247591                                                           15    9605
XP_005247590                                                           15    9605
NP_060413                                                              15    9605
>NP_000537
          Length = 393

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           RNTFR SVV
Sbjct: 209 RNTFRHSVV 217
>NP_001263689
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           RNTFR SVV
Sbjct: 170 RNTFRHSVV 178
>NP_001119584
          Length = 393

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           RNTFR SVV
Sbjct: 209 RNTFRHSVV 217
>NP_001119586
          Length = 341

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           RNTFR SVV
Sbjct: 209 RNTFRHSVV 217
>NP_001263625
          Length = 302

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           RNTFR SVV
Sbjct: 170 RNTFRHSVV 178
>NP_001119590
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           RNTFR SVV
Sbjct: 170 RNTFRHSVV 178
>NP_001263690
          Length = 354

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           RNTFR SVV
Sbjct: 170 RNTFRHSVV 178
>NP_001119585
          Length = 346

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           RNTFR SVV
Sbjct: 209 RNTFRHSVV 217
>NP_001263624
          Length = 307

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           RNTFR SVV
Sbjct: 170 RNTFRHSVV 178
>NP_001119588
          Length = 209

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNTFRRSVV 9
          RNTFR SVV
Sbjct: 77 RNTFRHSVV 85
>NP_001119587
          Length = 261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNTFRRSVV 9
          RNTFR SVV
Sbjct: 77 RNTFRHSVV 85
>NP_001119589
          Length = 214

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNTFRRSVV 9
          RNTFR SVV
Sbjct: 77 RNTFRHSVV 85
>NP_001263627
          Length = 182

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNTFRRSVV 9
          RNTFR SVV
Sbjct: 50 RNTFRHSVV 58
>NP_001263628
          Length = 187

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNTFRRSVV 9
          RNTFR SVV
Sbjct: 50 RNTFRHSVV 58
>NP_001263626
          Length = 234

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  RNTFRRSVV 9
          RNTFR SVV
Sbjct: 50 RNTFRHSVV 58
>NP_001190174
          Length = 165

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           R+T+RRS V
Sbjct: 124 RDTYRRSAV 132
>NP_001005
          Length = 165

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           R+T+RRS V
Sbjct: 124 RDTYRRSAV 132
>NP_001191020
          Length = 165

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           R+T+RRS V
Sbjct: 124 RDTYRRSAV 132
>NP_001189399
          Length = 291

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNTFRRSVV 9
           R+T+RRS V
Sbjct: 124 RDTYRRSAV 132
>NP_055797
          Length = 2341

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 785 RSTFRRQAV 793
>XP_005267484
          Length = 1515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 785 RSTFRRQAV 793
>XP_005267481
          Length = 2293

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 729 RSTFRRQAV 737
>XP_005267480
          Length = 2336

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 785 RSTFRRQAV 793
>XP_005267479
          Length = 2344

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 785 RSTFRRQAV 793
>XP_005267478
          Length = 2348

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 784 RSTFRRQAV 792
>XP_005267477
          Length = 2349

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 785 RSTFRRQAV 793
>NP_001127965
          Length = 74

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  RNTFRRSVV 9
          RN FRR+++
Sbjct: 38 RNDFRRNLI 46
>NP_689818
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           R TFRRS
Sbjct: 95  RKTFRRS 101
>XP_006723134
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           R TFRRS
Sbjct: 95  RKTFRRS 101
>XP_006723133
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           R TFRRS
Sbjct: 95  RKTFRRS 101
>XP_006723132
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           R TFRRS
Sbjct: 95  RKTFRRS 101
>XP_006723131
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           R TFRRS
Sbjct: 95  RKTFRRS 101
>XP_006723130
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           R TFRRS
Sbjct: 95  RKTFRRS 101
>XP_006723129
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           R TFRRS
Sbjct: 95  RKTFRRS 101
>NP_004360
          Length = 3177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RNTFRR 6
            RNTF+R
Sbjct: 2496 RNTFKR 2501
>NP_476508
          Length = 2971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RNTFRR 6
            RNTF+R
Sbjct: 2290 RNTFKR 2295
>NP_476507
          Length = 2570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RNTFRR 6
            RNTF+R
Sbjct: 1889 RNTFKR 1894
>NP_005804
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 731 SFRRSVV 737
>NP_002733
          Length = 912

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 738 SFRRSVV 744
>NP_001073351
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 549 SFRRSVV 555
>NP_001073350
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 706 SFRRSVV 712
>NP_001073349
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 706 SFRRSVV 712
>NP_057541
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 706 SFRRSVV 712
>NP_001191443
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  NTFRRSV 8
          NT+RRS+
Sbjct: 7  NTYRRSL 13
>XP_005258773
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 549 SFRRSVV 555
>XP_005267916
          Length = 920

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 746 SFRRSVV 752
>XP_005246123
          Length = 2770

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RNTFRR 6
            RNTF+R
Sbjct: 2089 RNTFKR 2094
>XP_005246122
          Length = 2977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RNTFRR 6
            RNTF+R
Sbjct: 2296 RNTFKR 2301
>XP_006712316
          Length = 3010

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    RNTFRR 6
            RNTF+R
Sbjct: 2329 RNTFKR 2334
>XP_006712043
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 472 SFRRSVV 478
>XP_006712042
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 558 SFRRSVV 564
>XP_006712041
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 558 SFRRSVV 564
>XP_005264295
          Length = 786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 627 SFRRSVV 633
>XP_005264294
          Length = 890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TFRRSVV 9
           +FRRSVV
Sbjct: 731 SFRRSVV 737
>NP_009052
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FRRSVV 9
           FRRSVV
Sbjct: 111 FRRSVV 116
>NP_694972
          Length = 1330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  RNTFRR 6
          RN+FRR
Sbjct: 42 RNSFRR 47
>NP_001010848
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           RN FRR+
Sbjct: 488 RNAFRRT 494
>NP_005968
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTFRRS 7
           NTFRR+
Sbjct: 115 NTFRRT 120
>NP_001159444
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           RN FRR+
Sbjct: 487 RNAFRRT 493
>NP_001159445
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           RN FRR+
Sbjct: 267 RNAFRRT 273
>NP_001123553
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 145 RHTFRRQNV 153
>NP_689417
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NTFRRSV 8
           N+FRR+V
Sbjct: 306 NSFRRNV 312
>NP_002653
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 145 RHTFRRQNV 153
>NP_898865
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTFRRS 7
           NTFRR+
Sbjct: 115 NTFRRT 120
>NP_898864
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTFRRS 7
           NTFRR+
Sbjct: 115 NTFRRT 120
>XP_006720248
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NTFRRSV 8
           N+FRR+V
Sbjct: 306 NSFRRNV 312
>XP_005267848
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NTFRRSV 8
           N+FRR+V
Sbjct: 306 NSFRRNV 312
>XP_006719917
          Length = 142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTFRRS 7
           NTFRR+
Sbjct: 115 NTFRRT 120
>XP_005266543
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTFRRS 7
           NTFRR+
Sbjct: 115 NTFRRT 120
>XP_005266542
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTFRRS 7
           NTFRR+
Sbjct: 115 NTFRRT 120
>XP_005269501
          Length = 720

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   RNTFRRS 7
           RN FRR+
Sbjct: 488 RNAFRRT 494
>XP_005247591
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 145 RHTFRRQNV 153
>XP_005247590
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   RNTFRRSVV 9
           R+TFRR  V
Sbjct: 145 RHTFRRQNV 153
>NP_060413
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NTFRRSV 8
           N+FRR+V
Sbjct: 306 NSFRRNV 312
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.338    0.138    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 420,061
Number of extensions: 580
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package