Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
XP_006726609                                                           17    4312
XP_006719787                                                           17    4312
XP_006710027                                                           17    4312
NP_114480                                                              16    5631
NP_055426                                                              16    5631
NP_114481                                                              16    5631
NP_061737                                                              16    5631
XP_005248757                                                           16    5631
XP_006715468                                                           16    5631
XP_005248756                                                           16    5631
XP_006715467                                                           16    5631
NP_060247                                                              16    7355
NP_003639                                                              16    7355
NP_690618                                                              16    7355
XP_006722027                                                           16    7355
XP_005257541                                                           16    7355
XP_005257540                                                           16    7355
XP_005257539                                                           16    7355
XP_005246167                                                           16    7355
XP_005246166                                                           16    7355
XP_005246165                                                           16    7355
XP_005246164                                                           16    7355
NP_054733                                                              15    9605
NP_004435                                                              15    9605
NP_001185761                                                           15    9605
NP_071754                                                              15    9605
NP_001185763                                                           15    9605
NP_001002810                                                           15    9605
NP_055459                                                              15    9605
NP_001182189                                                           15    9605
NP_001002812                                                           15    9605
NP_001182190                                                           15    9605
XP_006711719                                                           15    9605
XP_006711717                                                           15    9605
XP_006711716                                                           15    9605
XP_006711715                                                           15    9605
XP_006711714                                                           15    9605
XP_006711713                                                           15    9605
XP_006711710                                                           15    9605
XP_006711709                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RNLELRVLL 9
            RNLEL+VLL
Sbjct: 3294 RNLELQVLL 3302
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RNLELRVLL 9
            RNLEL+VLL
Sbjct: 3286 RNLELQVLL 3294
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RNLELRVLL 9
            RNLEL+VLL
Sbjct: 3247 RNLELQVLL 3255
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RNLELRVLL 9
            RNLEL+VLL
Sbjct: 3326 RNLELQVLL 3334
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    RNLELRVLL 9
            RNLEL+VLL
Sbjct: 3339 RNLELQVLL 3347
>XP_006726609
          Length = 2838

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RNLELRVL 8
            RNLE R+L
Sbjct: 2175 RNLEARIL 2182
>XP_006719787
          Length = 2838

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RNLELRVL 8
            RNLE R+L
Sbjct: 2175 RNLEARIL 2182
>XP_006710027
          Length = 2837

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    RNLELRVL 8
            RNLE R+L
Sbjct: 2174 RNLEARIL 2181
>NP_114480
          Length = 837

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RNLELRVL 8
           R+LELRV+
Sbjct: 527 RDLELRVI 534
>NP_055426
          Length = 5596

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    NLELRVLL 9
            NL+L+VLL
Sbjct: 2323 NLDLKVLL 2330
>NP_114481
          Length = 750

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RNLELRVL 8
           R+LELRV+
Sbjct: 527 RDLELRVI 534
>NP_061737
          Length = 935

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   RNLELRVL 8
           R+LELRV+
Sbjct: 527 RDLELRVI 534
>XP_005248757
          Length = 3591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NLELRVLL 9
           NL+L+VLL
Sbjct: 318 NLDLKVLL 325
>XP_006715468
          Length = 3744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NLELRVLL 9
           NL+L+VLL
Sbjct: 471 NLDLKVLL 478
>XP_005248756
          Length = 3905

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   NLELRVLL 9
           NL+L+VLL
Sbjct: 632 NLDLKVLL 639
>XP_006715467
          Length = 5550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    NLELRVLL 9
            NL+L+VLL
Sbjct: 2323 NLDLKVLL 2330
>NP_060247
          Length = 559

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RNLELRVLL 9
          RNL LRV L
Sbjct: 22 RNLRLRVHL 30
>NP_003639
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNLELRVLL 9
           +NLE +VLL
Sbjct: 771 KNLEQKVLL 779
>NP_690618
          Length = 1214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNLELRVLL 9
           +NLE +VLL
Sbjct: 815 KNLEQKVLL 823
>XP_006722027
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RNLELRVLL 9
          RNL LRV L
Sbjct: 22 RNLRLRVHL 30
>XP_005257541
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RNLELRVLL 9
          RNL LRV L
Sbjct: 22 RNLRLRVHL 30
>XP_005257540
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RNLELRVLL 9
          RNL LRV L
Sbjct: 22 RNLRLRVHL 30
>XP_005257539
          Length = 562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  RNLELRVLL 9
          RNL LRV L
Sbjct: 22 RNLRLRVHL 30
>XP_005246167
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNLELRVLL 9
           +NLE +VLL
Sbjct: 281 KNLEQKVLL 289
>XP_005246166
          Length = 944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNLELRVLL 9
           +NLE +VLL
Sbjct: 815 KNLEQKVLL 823
>XP_005246165
          Length = 1081

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNLELRVLL 9
           +NLE +VLL
Sbjct: 682 KNLEQKVLL 690
>XP_005246164
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNLELRVLL 9
           +NLE +VLL
Sbjct: 703 KNLEQKVLL 711
>NP_054733
          Length = 2136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   RNLELRVLL 9
           +NLEL+ LL
Sbjct: 770 KNLELKDLL 778
>NP_004435
          Length = 987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3 LELRVLL 9
         +ELRVLL
Sbjct: 1 MELRVLL 7
>NP_001185761
          Length = 2240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RNLELRV 7
           RN+EL+V
Sbjct: 113 RNIELKV 119
>NP_071754
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RNLELRV 7
           RN+EL+V
Sbjct: 184 RNIELKV 190
>NP_001185763
          Length = 2362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RNLELRV 7
          RN+EL+V
Sbjct: 47 RNIELKV 53
>NP_001002810
          Length = 173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RNLELRV 7
          RN+EL+V
Sbjct: 47 RNIELKV 53
>NP_055459
          Length = 2346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RNLELRV 7
          RN+EL+V
Sbjct: 47 RNIELKV 53
>NP_001182189
          Length = 141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RNLELRV 7
          RN+EL+V
Sbjct: 15 RNIELKV 21
>NP_001002812
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RNLELRV 7
          RN+EL+V
Sbjct: 47 RNIELKV 53
>NP_001182190
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RNLELRV 7
          RN+EL+V
Sbjct: 50 RNIELKV 56
>XP_006711719
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RNLELRV 7
           RN+EL+V
Sbjct: 113 RNIELKV 119
>XP_006711717
          Length = 2385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RNLELRV 7
           RN+EL+V
Sbjct: 113 RNIELKV 119
>XP_006711716
          Length = 2411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RNLELRV 7
           RN+EL+V
Sbjct: 113 RNIELKV 119
>XP_006711715
          Length = 2428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RNLELRV 7
          RN+EL+V
Sbjct: 47 RNIELKV 53
>XP_006711714
          Length = 2429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RNLELRV 7
          RN+EL+V
Sbjct: 47 RNIELKV 53
>XP_006711713
          Length = 2432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  RNLELRV 7
          RN+EL+V
Sbjct: 50 RNIELKV 56
>XP_006711710
          Length = 2494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RNLELRV 7
           RN+EL+V
Sbjct: 113 RNIELKV 119
>XP_006711709
          Length = 2495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   RNLELRV 7
           RN+EL+V
Sbjct: 113 RNIELKV 119
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.156    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 370,213
Number of extensions: 400
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package